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NICE Guidelines on Chronic Pain Management

d Jack Cush, MD

In the United Kingdom, where it is estimated that chronic pain affects one‑third to one‑half of the population, NICE (National Institute for Health and Care Excellence) has recently released an updated guideline on the management of chronic pain for people aged 16 years and over.

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Sinusitis Activity Linked to Brain Dysfunction

d Jack Cush, MD

Have you wondered why fibromyalgia, fatigue or cognitive dysfunction often co-associate with chronic sinusitis?

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IL-23 Targeting for Enthesitis in Psoriatic Arthritis

d MedPage Today

Treatment with guselkumab (Tremfya) was effective in resolving enthesitis among patients with psoriatic arthritis (PsA), a post-hoc analysis of two phase III trials found.

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Low Risk of Malignancy with Secukinumab

d Jack Cush, MD

Analysis of ongoing safety from the secukinumab (SEC) drug development program shows a low risk for malignancy in SEC patients treated for up to five years for either psoriasis, psoriatic arthritis (PsA) or ankylosing spondylitis (AS).

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DMARD Dropouts During COVID-19

d Jack Cush, MD

A full year from the onset of the SARS-COV-2 pandemic, rheumatologists are still seeing the consequences of COVID, with many patients avoiding usual care, follow-up visits, routine lab testing and with many self-stopping their antirheumatic meds, because it seemed like the right thing to do.

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News Feature: Low Risk of Malignancy with Secukinumab Analysis of ongoing safety from the SEC drug development program shows a low risk for malignancy in SEC patients treated for up to five years for either psoriasis, PsA or AS. https://t.co/tf1lWa03tF https://t.co/Ad1fOJZv4c

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Dr. John Cush RheumNow ( View Tweet)
In millions with hand OA, the thumb base (CMC1) is the most affected joint. metanalysis of 16 studies shows Xray CMC1 OA is more prevalent in females and is strongly associated with age. https://t.co/mNeXbWHdwa

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Dr. John Cush RheumNow ( View Tweet)

News Feature: DMARD Dropouts During COVID-19 Rheumatologists are still seeing the consequences of COVID, with many patients avoiding usual care, follow-up visits, routine lab testing and with many self-stopping their antirheumatic meds. https://t.co/gwtfvR9o53 https://t.co/92APJKUs0W

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Dr. John Cush RheumNow ( View Tweet)
Since the COVID vaccine rollout, more people have been eligible to receive the vaccine. However, not everyone chooses to get one. I have heard many reasons from my patients who are vaccine hesitant. Read more from Dr. Kathryn Dao ( @KDAO2011 ) https://t.co/f5gwBICEGy https://t.co/XgW6wVgo0F

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Dr. John Cush RheumNow ( View Tweet)
Hopkins Lupus Cohort (1168 patients) followed 24 months shows disease activity (measured by SELENA SLEDAI) increased risk of death (HR=1.22), renal damage (HR=1.24) & CV Dz (HR=1.17); But HCQ reduced death (HR=0.46) https://t.co/zBfitPV5Bl

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Dr. John Cush RheumNow ( View Tweet)

#RNL2021 takeaways from @KDAO2011 ""Liver damage is not an extra-articular manifestation of RA!"" - Dr. S Cohen "

Dr. John Cush RheumNow ( View Tweet)

#RNL2021 coverage from @doctorRBC "Dr. N Haroon talking about SpA treatment -TNFi can reduce spinal radiographic progression -Better to taper biologics in AxSpA than stopping -JAKinibs are coming "

Dr. John Cush RheumNow ( View Tweet)

Reasons for medication nonadherence: 1. Fear, 2. listed side effects, 3. Cost, 4. Complexity, 5. Confusion, 6. Depression, 7. more meds without clinical improvement. https://t.co/OBAfbFLIO9

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Dr. John Cush RheumNow ( View Tweet)

Metanalysis of IBD studies finds combo biologics may have efficacy in refractor IBD. 279 IBD pts Rx w/ dual biologic or JAKi Rx . Most common = TNFi + anti-integrins (48%), ustekinumab & integrins (19%); remission seen in 59% & 34%, higher w/ EIM https://t.co/RReyRuNXck

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Dr. John Cush RheumNow ( View Tweet)

Coverage from Dr. Robert Chao ( @doctorRBC) from #RNL2021 #RheumNow "How do you treat RA pts with persistent pain? Dr. Alan Matsumoto - “We have to understand that there may be other pathways of pain besides inflammatory”

Dr. John Cush RheumNow ( View Tweet)

News Feature: Anti-inflammatory Diet Control of Rheumatoid Arthritis https://t.co/fvOW9MeTTY https://t.co/6MZsFEC5aJ

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Dr. John Cush RheumNow ( View Tweet)
Thanks @uptoTate for sharing this great quote from #RNL2021 "Dactylitis to me is enthesitis and synovitis in the same digit." Dr. A. Kavanaugh #RNL2021"

Dr. John Cush RheumNow ( View Tweet)

Did you get a chance to listen to last week's podcast?#RheumNow Mistakes with Steroids https://t.co/qHtiyTzQme https://t.co/RI5XnZOmV2

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Dr. John Cush RheumNow ( View Tweet)
News Feature: GLP-1 Therapy in Knee Osteoarthritis Knee osteoarthritis (KOA) is best managed by weight loss, as the effects of most analgesic therapies have been marginal and debatable. https://t.co/0YB5rOuJiD #RheumNow https://t.co/LEFUBTlJq4

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Dr. John Cush RheumNow ( View Tweet)
Med nonadherence is universal 1) at 1 yr, only 48% pts still take their statins, 2) 1 in 4 pregnant asthmatics dont take their inhaled corticosteroids,. 3) half of psychiatric pts don’t take their psychotropic meds. What are the reasons for noncompliance? https://t.co/OBAfbFLIO9

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Dr. John Cush RheumNow ( View Tweet)

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