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IL-23 Targeting for Enthesitis in Psoriatic Arthritis

d MedPage Today

Treatment with guselkumab (Tremfya) was effective in resolving enthesitis among patients with psoriatic arthritis (PsA), a post-hoc analysis of two phase III trials found.

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Low Risk of Malignancy with Secukinumab

d Jack Cush, MD

Analysis of ongoing safety from the secukinumab (SEC) drug development program shows a low risk for malignancy in SEC patients treated for up to five years for either psoriasis, psoriatic arthritis (PsA) or ankylosing spondylitis (AS).

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DMARD Dropouts During COVID-19

d Jack Cush, MD

A full year from the onset of the SARS-COV-2 pandemic, rheumatologists are still seeing the consequences of COVID, with many patients avoiding usual care, follow-up visits, routine lab testing and with many self-stopping their antirheumatic meds, because it seemed like the right thing to do.

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Since the COVID vaccine rollout, more people have been eligible to receive the vaccine. However, not everyone chooses to get one. I have heard many reasons from my patients who are vaccine hesitant. Read more from Dr. Kathryn Dao ( @KDAO2011 ) https://t.co/f5gwBICEGy https://t.co/XgW6wVgo0F

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Hopkins Lupus Cohort (1168 patients) followed 24 months shows disease activity (measured by SELENA SLEDAI) increased risk of death (HR=1.22), renal damage (HR=1.24) & CV Dz (HR=1.17); But HCQ reduced death (HR=0.46) https://t.co/zBfitPV5Bl

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#RNL2021 takeaways from @KDAO2011 ""Liver damage is not an extra-articular manifestation of RA!"" - Dr. S Cohen "

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#RNL2021 coverage from @doctorRBC "Dr. N Haroon talking about SpA treatment -TNFi can reduce spinal radiographic progression -Better to taper biologics in AxSpA than stopping -JAKinibs are coming "

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Reasons for medication nonadherence: 1. Fear, 2. listed side effects, 3. Cost, 4. Complexity, 5. Confusion, 6. Depression, 7. more meds without clinical improvement. https://t.co/OBAfbFLIO9

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Metanalysis of IBD studies finds combo biologics may have efficacy in refractor IBD. 279 IBD pts Rx w/ dual biologic or JAKi Rx . Most common = TNFi + anti-integrins (48%), ustekinumab & integrins (19%); remission seen in 59% & 34%, higher w/ EIM https://t.co/RReyRuNXck

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Coverage from Dr. Robert Chao ( @doctorRBC) from #RNL2021 #RheumNow "How do you treat RA pts with persistent pain? Dr. Alan Matsumoto - “We have to understand that there may be other pathways of pain besides inflammatory”

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News Feature: Anti-inflammatory Diet Control of Rheumatoid Arthritis https://t.co/fvOW9MeTTY https://t.co/6MZsFEC5aJ

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Thanks @uptoTate for sharing this great quote from #RNL2021 "Dactylitis to me is enthesitis and synovitis in the same digit." Dr. A. Kavanaugh #RNL2021"

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Did you get a chance to listen to last week's podcast?#RheumNow Mistakes with Steroids https://t.co/qHtiyTzQme https://t.co/RI5XnZOmV2

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News Feature: GLP-1 Therapy in Knee Osteoarthritis Knee osteoarthritis (KOA) is best managed by weight loss, as the effects of most analgesic therapies have been marginal and debatable. https://t.co/0YB5rOuJiD #RheumNow https://t.co/LEFUBTlJq4

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Med nonadherence is universal 1) at 1 yr, only 48% pts still take their statins, 2) 1 in 4 pregnant asthmatics dont take their inhaled corticosteroids,. 3) half of psychiatric pts don’t take their psychotropic meds. What are the reasons for noncompliance? https://t.co/OBAfbFLIO9

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Study of 26 patients with chronic inflammatory cdiseases vaccinated with mRNA vaccines showed all with considerable immunogenic responses. No unexpected side effects seen and No flares of the underlying inflammatory disease was seen. https://t.co/7Q5bYp5A9i

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News Feature: Overview of New VEXAS Syndrome Medscape offers up an informative overview of the newly described syndrome called VEXAS discovered by researchers at the National Institutes of Health. https://t.co/9oDtahJ9yI #RheumNow https://t.co/5yBiiRPWb3

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RT from @KDAO2011"When Ustekinumab was developed, it was accidental that the p40 subunit targeted blocked both IL-12 and IL-23 (original intent to block only IL23) blocking I12 may decrease response to IL-23. this drug is better for skin than for joints - Dr. E Ruderman #RNL2021

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News Feature: Can Targeting RANKL in RA Heal Erosions? Treatment with denosumab (Prolia) helped heal bone erosions over 2 years among patients with rheumatoid arthritis whose disease activity was well controlled, researchers reported. https://t.co/kpYozqR8vD #RheumNow https://t.co/m0SjJzfp8m

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RT from @doctorRBC covering #RNL2021 -------- Make sure to screen your PsO and PsA for depression and mental health. Worsening depression can cause emotional stress, leading to worse disease. #RNL2021 #rheumnow

Dr. John Cush RheumNow ( View Tweet)

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