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A Polygenic Model for Still's Disease

Jack Cush, MD

Adult-onset Still's disease (AOSD) is systemic autoinflammatory disorder of unknown etiology.  It is considered among the febrile autoinflammatory etiologies.

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Early RA Journey - Patient Perspectives and Uncertainties

Jack Cush, MD

Canadian early RA (ERA) patients were interviewd to depict their perspectives from onset and diagnosis to referral and care. This report highlights the importance of patient pain and primary care physician (PCP) intake and referral. PCP and HCP delays in referral to a specialist still exist.

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Biosimilar Slow Growth in USA

Jack Cush, MD

A recent Forbes article, "Biosimilars Are Making Inroads In U.S., But It’s Still A Bumpy Ride", reviews the current state and reasons for slowish uptake of these significant cost-savings alternatives to biologic therapy in treating cancer and autoimmune disorders. The following are takeaway bullets from this informative article.

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Dr. Quotes (11.8.2024)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from this past week from RheumNow.com.

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Gut microbiome changes linked to onset of RA

EurekAlert!

Changes in the make-up of the gut microbiome are linked to the onset of clinically evident rheumatoid arthritis in those at risk of the disease because of genetic, environmental, or immunological factors, suggests research published online in the 

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Genes Linking Rheumatoid Arthritis and Osteoporosis

EurekAlert!

Rheumatoid arthritis is a common disease affecting an estimated 17 million people worldwide. The disease is caused by immune cells attacking the joints and can result in pain, swelling, and damage to the cartilage and bone.

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COVID-19 and Long-Term Risk of Autoimmune and Autoinflammatory Disorders

Jack Cush, MD

A Korean population based study found that people infected with COVID-19, especially severe COVID-19, had an increased risk of autoimmune and autoinflammatory connective tissue disorders.

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Dysregulated overproduction of angiopoietin-like protein 4 (ANGPTL4) may be involved in RA pathogenesis. Markedly elevated in RA tissues & is a regulator of angiogenesis & inflammation. Anti-ANGPTL4 inhibited Dz in mice and fibroblast-like synoviocyte migration &… https://t.co/aOpnxicQSs https://t.co/1BC8CxwF6V
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Dr. Quotes (11.8.2024) Dr. Jack Cush reviews the news and journal reports from this past week from https://t.co/V10S4oWdi3. https://t.co/NEXFg3Mp5G https://t.co/tUkGSgm6O7

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Early RA Journey - Patient Perspectives and Uncertainties Canadian early RA (ERA) patients were interviewd to depict their perspectives from onset and diagnosis to referral and care. This report highlights the importance of patient pain and primary care physician (PCP) intake… https://t.co/gwNL7iZIT5 https://t.co/SL0Jw0H8f6
Dr. John Cush RheumNow ( View Tweet)
T cell study of bronchoalveolar lavage fluid, blood & synovium from 17 early RA ACPA+ pts (TCR sequencing & immunophenotyping) found shared lung/joint T cell repertoires driven by smoking. The RA TCR repertoire shaped by MHC predisposition, smoking leading to autoimmunity… https://t.co/0lEVwEbKcW https://t.co/YrhV79AvX4
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Save the date! RheumNows will be covering #ACR24 from 11/14-11/19. Get ready for daily recaps, live streaming and much, much, more! https://t.co/vwNFU501di
Dr. John Cush RheumNow ( View Tweet)
Gut microbiome changes linked to onset of RA Changes in the make-up of the gut microbiome are linked to the onset of clinically evident rheumatoid arthritis in those at risk of the disease because of genetic, environmental, or immunological factors, suggests research published… https://t.co/gUgYLOKrI0 https://t.co/d75NmKup2U
Dr. John Cush RheumNow ( View Tweet)
Early Rx doesnt prevent Difficult to Tx RA (D2TRA). Propective study of 722 early RA pts Rx w/ MTX found after 73 mos 29% were D2TRA. 21.5% Rx w/ b/tsDMARD after 19 mos, yet 70% were uncontrolled. 5 yr retention rates were 40%. D2T predicted by pain & swollen joints… https://t.co/veaspuCHIE https://t.co/zjlTWQn4GQ
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Genes Linking RA and Osteoporosis People with rheumatoid arthritis often develop osteoporosis, a more serious condition, as a result of the bone damage caused by immune cells and as a side effect of certain medications. https://t.co/hEJc77gcln https://t.co/bmsV70riUc

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Dr. John Cush RheumNow ( View Tweet)
VA #RA registry study of 263 RA-ILD pts (mean 69 yrs, 95% male, 73% W, 85% smokers), finds the MUC5B promoter variant in 33.5%. While the MUC5B variant is assoc w/ RA-ILD risk, it does not predict survival or mortality. Other genetic & nongenetic factor must be responsible… https://t.co/sr1AtAZRDT https://t.co/KKD7RLnIqR
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New download available! Substitute Inflammatory Measures https://t.co/FiZSvvl5DA https://t.co/QwVefFLcHO

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Dr. John Cush RheumNow ( View Tweet)
Save the date! RheumNow will be covering #ACR24 from 11/14-11/19. Get ready for daily recaps, live streaming and much, much, more! https://t.co/rDMFH3wlbc
Dr. John Cush RheumNow ( View Tweet)
Study of at-risk & early RA Synovium suggests an early pathogenic myeloid signature (IL-1B+CCL20+ & SPP1+MT2A+ macrophage clusters) before disease onset. These display heightened CD40 expression, capable of shaping stromal cell responses https://t.co/CYmb1ro9g9 https://t.co/9pXbqHaQ2G

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Dr. John Cush RheumNow ( View Tweet)
Nationwide Readmissions Database (NRD) study of 133,187 #RA pts found that 48% were "frail". Hospital readmissions were significantly higher in the RA frail pts (57% vs 31%), & hospitalized, frail patients also had significantly higher mortality (3.36% vs 0.39%) & longer LOS… https://t.co/6lF4wrC87B https://t.co/mWJGIPbEjc
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