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Diagnosis & Treatment of Osteoarthritis Reviewed

d Jack Cush, MD

Katz, Arant and Loeser have published a comprehensive open-read overview of osteoarthritis (OA) of the hip and knee in JAMA; underscoring the impact, advances, disappointments and guidelines put forth. 

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Lung Preservation with Tocilizumab in Early Systemic Sclerosis

d Jack Cush, MD

Arthritis & Rheumatology has published the results of a subanalysis from tocilizumab (TCZ) clinical trials showing that Il-6 inhibition was associated with preservation of lung function patients with early systemic sclerosis (SSc).

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RheumNow Podcast – Systemic Sclerosis Pearls (2.19.2021)

d Jack Cush, MD

Dr. Jack Cush reviews nearly a dozen news and journal reports from the past 2 weeks on RheumNow.com, including the ACR's new COVID-19 vaccine guidance for patients with rheumatic disease.

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High Risk Cancer Profiling with Inflammatory Myositis

d Jack Cush, MD

A recent metanalysis of studies suggest you may be able to use certain clinical factors to stratify cancer risk in patients with idiopathic inflammatory myopathies (IIMs).

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Avacopan - Is it Really a Win for ANCA-Associated Vasculitis?

d Jack Cush, MD

The NEJM has reported the results of a study showing that avacopan, a C5a receptor inhibitor, is as effective as steroids at treating patients with antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV).

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Data from Danish Medical Birth Register shows PREG women w/ spondyloarthritis have more adverse pregnancy outcomes - including preterm birth (OR 1.5), elective C-section (OR 1.44), & epidurals (OR 1.11). Not increased were preeclampsia & rate small wt. https://t.co/opYsOBAR6A

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Survery of 438 RHEUMS on #AS & SpA - half use mod NY & ASAS criteria. 3/4 say Inflammatory Back Pain is axSpA specific, ~1/2 say uveitis/dactylitis are “very specific; less so heel enthesitis, peripheral arthritis. SI MRI was mor common w/ younger Rheums https://t.co/xfjvK5TO0t

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Medscape has published the 2021 Rheumatologist Lifestyle, Happiness & Burnout Report. Happy went down during COVID 79% to 49% 32% burnt out; 11% depressed 51% have workplace issues Half take 3-4 wks vacation https://t.co/g8UAHtiLIB

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Single center study of 43 pregnant SLE pts (57 pregnancies) - 96.5% intended to breast feed & 72% did (same as gen population). But SLE women had more early discontinuations @ 3 mos (assoc w/ smoking, BMI, joint Dz) HCQ assoc w/ longer breastfeeding https://t.co/VVVTVUeOT5

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Population based study of smoking cessation & risk of TKR in knee OA. TKR higher in recent quitters (26.7/1000PY vs 17.4/1000PY in smokers). adjusted HR=1.30 (95%CI:1.05-1.59). TKR risk was higher among quitters with weight gain (HR=1.42) https://t.co/6onQWQeFcI

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CTD associated pulmonary HTN has improved sincd 2010. Metanalysis of 11 RCTs (4,329 pts) & 19 registries (9,739 pts); 5 RCTs find PAH Rx assoc w/ 36% lower mortality/morbidity. Registry data shows better PAH survival since 2010 (73% vs 65% @3yrs) https://t.co/0BkO70AQfi

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Analysis of incident #RA in UK Clinical Practice registry shows recent prednisone >=7.5mg/d is assoc w/ hypertension in RA. In 17760 RA pts, 42% were Rx steroids; recent GC yielded a 17% increase in HTN (HR 1.17); only >7.5mg/D implicated https://t.co/qUKs2oZZUV https://t.co/pWmD4nKs6U

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QD Clinic - When to do Genetic Testing in Febrile Patients Indications for Genetic testing for autoinflammatory disorders https://t.co/1vnR1JQAxZ https://t.co/x2wyLHhjgN

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QD Clinic - Hemoptysis and SLE Key Features of Alveolar Hemorrhage in lupus https://t.co/qNZYDYmn70 https://t.co/sitc7Tlf5V

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RheumNow Podcast is now up! Systemic Sclerosis Pearls Dr. Jack Cush reviews nearly a dozen news and journal reports from the past 2 weeks on https://t.co/fxtCOkxTER, https://t.co/nKRmKWR0Bd https://t.co/ESdycxLoCz

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High Risk Cancer Profiling with Inflammatory Myositis A recent metanalysis of studies suggest you may be able to use certain clinical factors to stratify cancer risk in patients with idiopathic inflammatory myopathies (IIMs). https://t.co/TjmdGtdDQG https://t.co/tlfVU031fY

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QD Clinics - Traveling to Medical Meetings during COVID Is it Safe to Travel? https://t.co/flELrZbjnw https://t.co/ixebtW71fx

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Avacopan - Is it Really a Win for ANCA-Associated Vasculitis? The NEJM has reported the results of a study showing that avacopan, a C5a receptor inhibitor, is as effective as steroids at treating patients with ANCA-AAV. https://t.co/vWmhEhX8Z3 https://t.co/omXpouPKoJ

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SF analysis usually confirms dx, but changes dx 14%. 264 SF samples showed MSU crystals in 89% gout, 9% of CPPD pts. CPP crystals found in 54% of CPPD, 43% of OA & 7% of gout pts. Ca hydroxyapatite seen 1/3 RA, 1/2 OA & 2/3 CPPD https://t.co/B8UkHagXK3 https://t.co/UTncLo6Fyu

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Alveolar Hemorrhage and Mortality in Lupus Metanalysis of patients with DA), show this to be a rare and life-threatening complication of SLE, that is more apt to affect older, severe lupus patients with active infection. https://t.co/EILQZTYYjk https://t.co/kDAFuYIJuH

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