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The Inflammation Reflex (5.20.2022)
Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. This week, neuroimmunology leading to therapy, the cold shoulder approach and Regulatory updates from the FDA.
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Biologic Persistence in Psoriatic Arthritis and Psoriasis
Two recent studies examined the durability and persistence of biologic agents in patients with psoriasis (PSO) and psoriatic arthritis (PsA) and while some differences were noted overall persistence was low 3 years later.
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VA and Marketscan data analysis ~345k RA pts shows multimorbidity increased in RA; over-represented are cardiopulmonary, cardiometabolic, and mental health and chronic pain disorders (OR 1.17 - 2.96). https://t.co/awcGQPAdiN https://t.co/c4mLkDzvCM
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Inflammatory Arthritis Spread by ATP and Neural Crosstalk
A novel study suggests that a reflex neural signaling at sites of inflammation may lead to spread to other inflammatory sites via and ATP-mediated neural crosstalk.
https://t.co/vaFjqCPKtp https://t.co/RQV6qFh1pw
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Biologic Persistence in Psoriatic Arthritis and Psoriasis
Recent studies examined the durability and persistence of biologic agents in patients with PSO and PsA and while some differences were noted overall persistence was low 3 years later.
https://t.co/sqxVaLnXEY https://t.co/yUPWYkRxva
Links:
Dr. John Cush RheumNow ( View Tweet)
Watch: Lupus Nephritis: The Blind Men and the Kidney with Dr. Joan Merrill
Joan Merrill discusses treatment of lupus nephritis. This was previously recorded at RheumNow Live 2022.
https://t.co/IDjOT3Acs0 https://t.co/HkYcoRx5P4
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Countdown to Step 2, each week I'll be posting one of my favorite doodles from studying! This week- Pulmonary Arterial Hypertension #Meddoodles https://t.co/Hj1i87zZbA
Sarah Lyon sarahthelyon ( View Tweet)
Wiki Guidelines Approach to Pyogenic Osteomyelitis
https://t.co/4HD60dbPkk https://t.co/t4xHSWKXys
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Data from Scleroderma Lung Study (CTX vs MMF in PSS) shows that early progression of ILD by CXR scoring (≥ 2% at 12 or 24 months) experienced significantly worse long-term survival than those with stable Xrays (P = .014). https://t.co/hv2WNJ4Chr https://t.co/W5RIhoIGtT
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Multimorbidity Burden in Rheumatoid Arthritis
Crowson and colleagues at the Mayo Clinic have shown that rheumatoid arthritis (RA) patients have a higher prevalence of multimorbidity with as many as 44 different morbidities of interest in RA.
https://t.co/O5U6VXalwa https://t.co/BzXyMGz0ms
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Many have quoted and shown this image of Ankylosing Spondylitis in a young military recruit at age 25, 35, 45, 50 & 51yrs. This may be the MOST used slide in rheum! It comes from the work of Toronto's Dr. Hugh Little, who sadly passed away at age 58 yrs. https://t.co/e3Zf1OUqtX https://t.co/zOhnQf3ep9
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Rising Incidence of Systemic Lupus Erythematosus
Data from Olmstead county, MN over the past four decades shows that the incidence and prevalence of systemic lupus erythematosus (SLE) is increasing.
https://t.co/GUakRwwWQw https://t.co/LPnVMTT8Ro
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Join us on May 24 at 7pm for Tuesday Night Rheumatology: RA - Best Management
We’ll focus on:
Drug Cycling Vs Switching in RA
Janet Pope, MD, MPH, FRCPC
Multimorbidity in RA
Elena Myasoedova, MD, PhD
Preventing RA
Karen Costenbader, MD
https://t.co/Vc5uECptIo https://t.co/fu3qACdHkL
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Dr. John Cush RheumNow ( View Tweet)
Watch: The Music of Rheumatology with Dr. Ronan Kavanagh
What does music have to do with rheumatology? Quite a lot, actually.
https://t.co/R9n0vEYB2J https://t.co/M8Jpg1g6QI
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Dr. John Cush RheumNow ( View Tweet)
Relevance of Raynaud’s in Systemic Sclerosis
A recent analysis suggests that RP should be characterized based on color change and the presence of other symptoms to know whether RP portends more serious manifestations.
https://t.co/rLo6Ju5LV1 https://t.co/gAQAYxe9rL
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Dr. John Cush RheumNow ( View Tweet)
Israel study of 171 kids w/ MIS-C (med age 8 (5-12): Dx#s - 59 during Alpha , 79 Delta , & 33 Omicron waves. All Rx w/ IVIG + steroids. 6-15% prev recv COVID VAX, none ICU admitted. Worse Dz & higher incidence during alpha wave (54.5/100K) https://t.co/wAby8uKIH4 https://t.co/zc19zeUKpq
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From 4 Nordic Registries, 24083 RA patients starting 41K courses of bDMARDs shows RA patients had an 80% higher risk of acute coronary syndromes than in the general population. ACS risk on bDMARDs did not improve at 3yrs or 5 yrs https://t.co/TX3jnIXkrW https://t.co/I34UvWH3qd
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Ontario population study shows that musculoskeletal disorders account for 12.3% of all adult emergency dept. visits and 28.5% outpatient physician visits https://t.co/Sq9n7RkIYK https://t.co/lKtQqR5Ja3
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Watch: The Almighty ANA
Dr. Lipsky discussed how our thinking and use of ANA and serologic testing has evolved and is crucial to outcomes and trials in his lecture, The Almighty ANA, presented during the at #RNL2022 in March. #lupus
https://t.co/Xxxj18badY https://t.co/5pwV4xSGDx
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Local cryotherapy in adjuvant-induced arthritis in rats given bid resulted in lower arthritis scores, structural damages, less vascular inflammation/endothelial activation (less mRNA CXCL-1, IL-6, IL-1β, leukocyte infiltration, lower IL-17A and OPG https://t.co/b4cAa9E4PJ https://t.co/vhwWoY8Ujw
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