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RheumNow Podcast – Rheumatology Burnout (1.29.2021)

d Jack Cush, MD

Dr. Jack Cush reviews this past week's journal articles and news features on RheumNow.com. Colchicine, vaccine rollout, risk of RA in endometriosis patients, tREACH trial, lupus nephritis news, rheumatology burnout and more.

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Calculating Serious Infection Risk in IMID Patients

d Jack Cush, MD

Predictive modeling of data derived from the DANBIO registry (of treated IMID patients) revealed a 4 fold increased risk of serious infection (SIE) in those starting biologic DMARD (bDMARD) treatment. From this large dataset, researchers developed a simple prediction model to estimate future infection risk that may inform shared decision-making in individual patients.

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High Placebo Responses in SLE Trials

d Jack Cush, MD

A systematic review by Urowitz and colleagues examined placebo responses in randomized controlled trials of non-renal, non-neuropsychiatric SLE patients showing unexpectedly high placebo responses; with more than one-third of the placebo-treated SLE patients responding by validated outcome measures.

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Lupus Nephritis Despite Low Level Proteinuria

d Jack Cush, MD

Kidney International reports on a series of systemic lupus erythematosus (SLE) patients, who despite inactive urinary sediment and low level proteinuria, had a high rate of glomerulonephritis (GN) proven by renal biopsy; moreover, the LN was not predicted by laboratory abnormalities.

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JAK Inhibitor Misses Endpoint in Safety Study. Now What?

d MedPage Today

Pfizer announced results Wednesday from its FDA-mandated postmarketing safety study of tofacitinib (Xeljanz), and they don't bode well for the drug and possibly others in its class.

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UT Southwestern Grand Rounds w/ Dr. Kathyrn Dao @KDAO2011 - lecturing on lupus. Showing that the population rate of ANA has increased over time - NHANES shows 44 million in the USA have +ANA! @UTSWInternalMed @UTSWIMchief https://t.co/qU5gzuAD9j
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QD Clinic - Dadgummit, Where's Waldo's COVID Vaccine? My rant on the COVID vaccine unavailability, and what we can - and can't - tell patients. https://t.co/VKrDgvuXqt https://t.co/zuNe8lEaR4

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Colchicine suppresses MSU & CA pyrophosphate crystal activation of Nod-Like Receptor Protein 3 (NLRP3) inflammasome, thereby suppressing caspase-1 activation and the subsequent release of IL-1β and IL-18. Great review by Pillinger et al https://t.co/n7MHtSviT5

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New download available--Televideo Joint Exam Checklist https://t.co/XnyCW2eak8 https://t.co/WMdkra6SYv

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QD Clinic - Rhabdo or Not https://t.co/KmKPTaFOtr https://t.co/9AvOIOOmci

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Urate Lowering Therapy During Acute Gout Acute gout has its well-defined protocols, and most state that urate lowering therapy (ULT) should be continued; but does ULT affect outcomes in an acute gout attack? https://t.co/aDHpU1I2d2 https://t.co/QihJNhMW8L

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Among 335 AAV pts, 18% had venous thromboembolism (VTE). The incidence rate of AAV-related VTE was 2.4/100 PYs and was higher in the first 3 months post–AAV diagnosis (20.4/100 PY) and decreased over time. Age & BVAS were predictive of VTE.https://t.co/Arb2gk27B7

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QD Clinic - Arthritis and Colitis https://t.co/U5NrQuIcrd https://t.co/LbuRy9pTIl

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Vaccine Rollout: Fed has delivered about 44.4 million Vax doses to states (~24 mill doses given). Estimated 6% (19.9 mill) have had one vax dose and 1% (3.5 mill) 2 doses. 2.7 of 3 million elderly in nursing homes long-term-care have recv >= 1 vax dose .https://t.co/HaoIRP4Uoo

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Rheumatologists Rank 2nd in Physician Burnout The 2021 Medscape Survey on Physician burnout ranks rheumatology second, just behind Critical Care medicine. https://t.co/nIDqa5TCqG https://t.co/psem4wYIlN

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ACR Convergence 2020 Fireside Chats- top presentations in nr-axSpA, AS, axial PsA and Still’s disease. Sponsored by Novartis Medical Affairs Unable to attend the key sessions at #ACR20? Listen to the experts as they weigh in on the top abstracts. https://t.co/oGwmEXNaur https://t.co/qjwfaXXnXQ

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The risk of RA was studied in cohort of 14,463 endometriosis pts. RA risk was higher in those w/ endometriosis [adjusted HR 1.75), and also w/ age ≥45 years (adj HR 1.50) or with autoimmune disease (adj HR 6.99). https://t.co/sPouzyFI3H https://t.co/lDjSgLxXfV

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13 patients with SAPHO syndrome with nail lesions and palmoplantar pustulosis were treated wtih tofacitinib with significant improvement in nail scores (58-77%), psoriasis scores, QOL, DQLI and acute phase reactants. https://t.co/J8yB4pRHS1

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Rheums: Got a Rheumatology question or case for RheumNow? Record it here and we'll feature it on an upcoming podcast. Tell us your name and where you practice rheumatology. https://t.co/wzNmOzH4VE https://t.co/6w8CAAUkO6

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RheumNow COVID-19 Updates https://t.co/TiB7739ONL

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