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SLE and Pregnancy Outcomes

Jack Cush, MD

Obstetric complications and poor pregnancy outcomes are not uncommon in women with SLE, especially with active disease.  A large Spanish cohort trials shows that term pregnancy is more likely before the diagnosis of SLE and that poorer pregnancy outcomes were associated with antibody positivity to anticardiolipin IgG and anti-beta-2- glycoprotein IgG/IgM, but not lupus anticoagulant.

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Anti-Drug Antibodies with Biologics (7.14.2023)

Jack Cush, MD

Dr. Jack Cush Reviews the news and journal reports on CVA, TKA, PJP, ADA, and more!

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ICYMI: Hydroxychloroquine Dose and Risk for Incident Retinopathy

Jack Cush, MD

A cohort study in Annals of Internal Medicine shows that higher hydroxychloroquine doses was associated with progressively greater risk for incident retinopathy. The study aimed to assess the long-term risk for incident hydroxychloroquine retinopathy and examine the degree to which average hydroxychloroquine dose within the first 5 years of treatment predicts this risk.

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Giants,women,rheumatology

ICYMI: 25 Great Women in Rheumatology

Jack Cush, MD

I reached out to many leaders in rheumatology and asked: who are the great women in rheumatology who should be recognized? This was prompted by a smart article in Annals of Rheumatic Disease written by Drs. Tuhina Neogi (Boston) and Nicola Dalbeth (N. Zealand), entitled "Where are the women ‘Heroes and Pillars of Rheumatology’?

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ICYMI: New Laboratory Insights for the ANA+ Consult

Jack Cush, MD

A new study suggests that use of ELISA assays for CXCL-10 and IFN-α can predict which ANA+ individuals may progress to developing a systemic autoimmune rheumatic disease (SARD).

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GI, microbiome, bacteria

Gut Microbiome Alterations in Lupus Patients

EureAlert!

Recurrent bouts of systemic lupus erythematosus, marked by the body’s immune system attack of its own tissues, closely tracked with measurable upticks in growth in the gut of a certain species of bacteria.

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Full read review of clinical trials in CTD-ILD, specifically looking at: - Frequency of ILD in RA, SLE, SSc, Sjogr, PM/DM & Rx outcomes - Results w/ RTX, MMF, CYC, IL-6i, nintedinib, pirfenidone, Stem cell transplant https://t.co/HyCsrzejLU https://t.co/ejJKOtXupC

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Dr. John Cush RheumNow ( View Tweet)
35 SLE pts Rx w/ RTX x 3 ys-anti-RTX antibodies found @3 yrs in 64%, higher if previously RTX treated (vs naive). ADA+ had signif lower median RTX levels at 6 mos (P = 0.0018) and increased relapse rates. In vitro showed neutralizing capacity these Abs https://t.co/oV7nHxiS4s https://t.co/p55MvcLDFn

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Dr. John Cush RheumNow ( View Tweet)
Full read review of "Treatments for Lupus Nephritis" from Isenberg et al - discussing: - Pathogenesis, outcomes - Conventional Rx - B cell targeting: BEL, RTX, Obintuzumab, Atacicept & more - Sequential Rx: Synviose, BEAT, BLISS-Believe - JAKi & more https://t.co/X0xn9FeL0j https://t.co/Fiyf5Drh93

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In Memoriam: Dr. K. Frank Austen (1928-2023) Rheumatology mourns the loss of a historic leader in the field, Dr. K. Frank Austen, who died at his home in Maine on June 23, 2023, at the age of 95. https://t.co/mtRQ8D5bWt https://t.co/fAQ9ebK95R

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Dr. John Cush RheumNow ( View Tweet)
Full read review of clinical trials in CTD-ILD, specifically looking at: - Frequency of ILD in RA, SLE, SSc, Sjogr, PM/DM & Rx outcomes - Results w/ RTX, MMF, CYC, IL-6i, nintedinib, pirfenidone, Stem cell transplant https://t.co/gUOV3IWt4P https://t.co/WM1HvTmNCq

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Dr. John Cush RheumNow ( View Tweet)
RT @drdavidliew : Autoimmune disease diagnoses slowly on the rise, despite reduced smoking - but that’s now 10% of the population, & many patients have more than one. Most are lifelong. Surely this needs more investment?? CPRD data from the UK https://t.co/RuPZ0ys0xW

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Dr. John Cush RheumNow ( View Tweet)

RT @Yuz6Yusof : #EULAR2023 #POS0116 How does Voclosporin fare in #lupus pts w/heavy proteinuria (=>2g/day)? Pooled Analyses from Phase 2&3 RCTs showed consistent improvement in renal response regardless of demographics or clinical characteristics. An option this resistant group

Dr. John Cush RheumNow ( View Tweet)

#EULAR2023 #POS0112 Consistent with clinical response, Post-hoc analyses of Phase 2 RCT of Deucravacitinib (Tyk2-i) showed this therapy suppressed both IFN and B cell pathways - a broader mode of action in reducing #SLE pathophysiology. Look forward to Phase 3 results

Dr. John Cush RheumNow ( View Tweet)

RT @bella_mehta : Diagnostic delay in #lupus is really prevalent! #EULAR2023 @RheumNow 20% with new lupus diagnosis are hospitalized! 20% diagnosis is delayed for more than 3 months!

Dr. John Cush RheumNow ( View Tweet)

RT @Janetbirdope : #SLE #EULAR recommendations What is new - use LESS #glucocorticoids, aim for none or 5 mg/d or less, use #biologics early if needed to prevent damage, #lupus #nephritis consider less pulse dose if using, voclosporin vs Belimumab ? it depends #EULAR2023

Dr. John Cush RheumNow ( View Tweet)

RT @Janetbirdope : #Top #EULAR learnings #SLE #recommendations 1 Limit #prednisone 2 use #biologics early if poor prognosis 3 #lupus #nephritis - treat early with #belimumab or #voclosporin and more Rx in #RCTs #gamechanger

Dr. John Cush RheumNow ( View Tweet)

Gut Microbiome Alterations in Lupus Patients Recurrent bouts of systemic lupus erythematosus, marked by the body’s immune system attack of its own tissues, closely tracked with measurable upticks in growth in the gut of a certain species of bacteria. https://t.co/eGk4EQsVES https://t.co/PiFKxJWD13

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Dr. John Cush RheumNow ( View Tweet)
Why Patients Don't Take Medicines This report examines the characteristics of adults aged 18–64 who took prescription medication in the past 12 months and did not take medication as prescribed due to cost. https://t.co/zuPgMjKYbh https://t.co/62cG9LDYWi

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Dr. John Cush RheumNow ( View Tweet)
EULAR 2023 Lupus Highlights https://t.co/CGybJRjDDK https://t.co/2kkB1hX2J5

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Dr. John Cush RheumNow ( View Tweet)
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