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Little Effect with Multimodal Treatment of CMC1 Osteoarthritis
A randomized clinical trial of patients with CMC1 osteoarthritis shows modest benefits when a combination of conservative treatments (education, splinting, hand exercises, 1% diclofenac sodium gel) was used compared to education alone. While there were small to medium benefits with regard to hand function, there was no benefit in pain outcomes.
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Golimumab Effective in non-radiographic Axial Spondyloarthritis
The GO-AHEAD study was designed to assess the long-term efficacy and safety of golimumab (GLM) in non-radiographic axial spondyloarthritis (nr-axSpA). After the 16-week, placebo [PBO]-controlled double-blind phase, 189/198 (95.5%) entered the long-term extension (OLE) for 36 weeks wherein G
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Lupus Activity Affects Mortality
Each one-unit increase on a disease activity score during the first year after enrollment into a systemic lupus erythematosus (SLE) cohort was associated with a significant increased risk for death and organ damage during subsequent follow-up, researchers reported.
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CARD8 SNP rs11672725 (OR 3) may be a Genetic Variant for AdultStill’s Disease. AOSD has unregulated NLR3 inflammasome activity. Study of 66 AOSD & 128 controls, showed AOSD to have low CARD8, higher caspase-1, IL-1β and IL-18; more systemic Sxs https://t.co/rpypR4cLfM
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