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Lots of JAK safety studies in #ACR20. Abst#0237 pooled 5 RCTs on UPA. Good safety numbers and low VTE rates, but watch out for herpes zoster trend, elevated in UPA (30>15mg) compared to MTX and ADA. @RheumNow
Eric Dein ejdein1 ( View Tweet)
Healthcare disparity posters at #ACR20 impactful! Abst#0049 showed decreased Patient Portal activation in UNC in rural area, minority race, older age, lower income, Medicaid, non-English speaker. Interested in portal usage, not just activation. @RheumNow
Eric Dein ejdein1 ( View Tweet)
The #ACR20 Great Debate is on! One issue point is lab monitoring on TNF vs JAK. What's your take? @RheumNow
Eric Dein ejdein1 ( View Tweet)
Who can have sustained DMARD-free remission (SDFR)? Abst#0479 says early DAS response after DMARD initiation in ACPA-negative patients #ACR20
@RheumNow. Who do you try for DMARD-free intervals? https://t.co/EOfPt4YQAu
Eric Dein ejdein1 ( View Tweet)
ACR President Dr. Ellen Gravallese reminds us in the opening remarks of #ACR20 of Francis Bacon’s prudent words: “Prosperity is not without many fears and distastes; and adversity is not without comforts and hopes.” @RheumNow
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
“As the content experts in immunology, our knowledge & insights are relevant... We should always be in the room [that discussions about patient care and development of vaccines] happen.” Dr. Ellen Gravallese. #ACR20 @RheumNow
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
”As the content experts in immunology, our knowledge and insights are relevant... We [Rheumatologists] should always be in the room that such discussions [about patient care and development of vaccines] happen. “ - Dr. Ellen Gravallese, ACR President #ACR20 @RheumNow
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Thank you to the ACR Executive Committee for all your hard work and efforts. And thank you Dr. Gravallese for an amazing start to the #ACR20 and your great leadership. @RheumNow https://t.co/eRrXo21v0Y
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Congratulations, Dr. James O’Dell on the ACR’s highest reward: the President Gold Medal. I had the privilege of meeting him years ago— such an exemplary person, physician, and leader. #ACR20 @RheumNow https://t.co/4R23itqGZJ
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Infectious disease physician, Dr. Eric Rubin, kicks off the ACR keynote address by reminding us that there are real alliances between Infectious Disease doctors and Rheumatologists in that inflammation can cause damage during infection! #ACR20 @RheumNow https://t.co/pcOS1HbfX7
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Reminder of the glucocorticoids (GC) paradigm: don’t use them early during viral replication as morbidity and mortality (M&M) can increase with early use! But GCs CAN prevent the late complications that cause M&M when used at the appropriate time point. #ACR20 @RheumNow https://t.co/l2e0J1nANd
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Determining safety of a vaccine requires NUMBERS (more subjects to detect rare, serious side effects) and TIME (longer trials to be able to detect more delayed side effects) per Dr. Eric Rubin’s (ID physician’s) keynote address at #ACR20 @RheumNow
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Perform (annual) skin exams in patients in MTX based on discovery of a new adverse effect signal with use of low dose MTX (median dose 15 mg/wk) with a NNH of 167! Screening 160 RA patients on MTX will identify 1 skin Ca. Amazing #ACR20 Year in Review by @JYazdanyMD. @RheumNow https://t.co/hUCzKSYZnB
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
*When will we have a vaccine?
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
“When we will have a vaccine. The answer is not so simple. Safety [of vaccines] is an important component of making a decision to move forward.”- Dr. Eric Rubin at #ACR20.
We want a vaccine that is both SAFE and EFFECTIVE! @RheumNow
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Abst#0142 at #ACR20, a post-hoc analysis of FINCH2, shows that filgotinib (FIL)(Jak1-i) + csDMARD improved the degree of activity impairment in a clinically relevant manner compared to placebo + csDMARD in pts w/ inadequate response to bDMARD . @RheumNow https://t.co/6M42LUVuht
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Great #rheumtwearls #ACR20 https://t.co/HzKkhnArvr
Marissa Blum blum_marissa ( View Tweet)
ACPA in patients with RA are multireactive. How can one antibody bind to so many proteins? ACPA recognize very small linear epitopes shared by many posttranslationally modified proteins.
2F012. Antibodies in RA. #ACR20. <TK https://t.co/OUqshFoxSb
ARD & RMD Open ARD_BMJ ( View Tweet)
Year in review @JYazdanyMD take home points from 2 key positive trials (finally!) in SLE this year #ACR20 @RheumNow https://t.co/74SVwNavPK
Richard Conway RichardPAConway ( View Tweet)
#ACR20 Year in Review @JYazdanyMD presenting PEXIVAS results. The proof of efficacy equivalence and safety superiority for the low dose steroid arm is a game-changer @rheumnow https://t.co/bJ1WLL71sB
Richard Conway RichardPAConway ( View Tweet)