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COVID Transmission from Young to Old

d Jack Cush, MD

The CDC has analyzed temporal trends in percent positivity by age group in COVID-19 hotspot counties before and after their identification as hotspots.

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Tofacitinib and Thromboembolic Risk

d Jack Cush, MD

Mease and colleagues have reviewed the tofacitinib drug development and clinical trial data, finding the risk of venous (VTE) and arterial thromboembolism (ATE) to be low and augmented in patients with baseline cardiovascular abd VTE risk factors and those taking higher doses of tofacitinib (10 m

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Thrombotic Risk in Rheumatoid Arthritis Linked to Disease Activity

d Jack Cush, MD

A large RA cohort study from the Swedish Rheumatology Quality Register shows a higher risk of venous thromboembolism (VTE) in rheumatoid arthritis (RA)  and that risk is linked to RA disease activity. 

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Hydroxychloroquine Shows No Benefit in Hospitalized COVID-19 Patients

d Jack Cush, MD

The NEJM reports on a controlled clinical trial showing patients hospitalized with Covid-19 given hydroxychloroquine (HCQ) do not have a lower incidence of death compared to those receiving routine care.

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RheumNow Podcast – Bad Disease & Bad Outcomes (10.9.20)

d Jack Cush, MD

Dr. Jack Cush Reviews the news and journal articles from the past week on RheumNow.com.

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Biologics Beneficial in Eosinophilic Vasculitis

d

Two biologic therapies showed promise in the treatment of refractory or relapsing eosinophilic granulomatosis with polyangiitis (EGPA) in a retrospective European study.

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Sustained Remission Off Therapy Unlikely in GPA

d Jack Cush, MD

A French Vasculitis Study Group analysis of their granulomatosis with polyangiitis (GPA) reveals that after 10 years, only 7% of GPA patients achieved sustained remission off therapy (SROT) and have never relapsed.

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Observational study of 123 Spanish rheumatic dz pts w/ COVID-19, finds 54 hospitalized. Admitted pts were 69.7 yrs, and 22% died. Admission was assoc w/ older age, autoimmune dz (vs inflammatory arthritis; OR: 3.55), but not DMARD Rx. https://t.co/UWNyhOKbvF

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Dr. John Cush RheumNow ( View Tweet)

In elderly AAV, initial steroid dose should be rapidly reduced be required to safe outcomes. Study of 179 AAV pts 80yrs old w/ high Birmingham Vasculitis Score 16.1. 94% MPO+, 6% PR3+, Serious infections seen in high-dose Pred vs low dose (43% vs. 22%) https://t.co/mZbtKvPUIX

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Dr. John Cush RheumNow ( View Tweet)

Studies of inflammasome generated kinase activity (using UCN-01-mediated inflammasome activation) shown to discriminate familial Meditteranean fever patients from healthy donors and other inflammatory disorders https://t.co/euThYpSQMx

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Dr. John Cush RheumNow ( View Tweet)

Study of 196 RA pts shows lung Dz common by chest CT, regardless of serostatus. RA lung=higher mortality (HR of 5.3). RA lung dz found in 28%; 16% had ILD, 14% bronchiectasis, 9.5% w pleural dz. RA lung dz in both seropositive (29%) & seronegative (28%) https://t.co/upNX7cvlWq

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Dr. John Cush RheumNow ( View Tweet)

Study of 5792 RA pts from 11 RCTs compared ACR Boolean remission with (4V) or without Pt Global scores (3V) using Xray & functional outcomes. 3V (TJC28, SJC28, CRP CRP mg/dL<=1) was as validi as 4V-remission in predicting Xray, less so functional, outcomes https://t.co/r1azrh3SHS

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Dr. John Cush RheumNow ( View Tweet)

Nonradiographic axial spondyloarthritis= meeting axSpA criteria without Xray sacroiliitis. Swiss study compared women & men w nr-axSpA. Women had a longer Dx delay, higher Dz activity & enthesitis, less B27+ & signif lower TNFi resp rate (OR 0.19) vs Men https://t.co/ykAHfimOd5

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Dr. John Cush RheumNow ( View Tweet)

The RheumNow Podcast is up - Bad Disease & Bad Outcomes. COVID consequences, TNFi Switching in SpA, psychosis in lupus? Watch it here> https://t.co/ced3cKg5eB or listent to podcast on iTunes> https://t.co/FHJv01AAbC or SoundCloud> https://t.co/e4nWr3wECz

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Dr. John Cush RheumNow ( View Tweet)

Congratulatons to Professor Ian McInnes on his appointment as Vice Principal & Head of College to the College of Medical, Veterinary and Life Sciences (MVLS), within the University of Glasgow. https://t.co/m3joegAEsK
Dr. John Cush RheumNow ( View Tweet)
Congratulations to #NIH's Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases (NIAID), on winning the 2020 Federal Employee of the Year award! #Sammies2020 https://t.co/S5n3M97o8d

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Dr. John Cush RheumNow ( View Tweet)

Another case of COVID-19 Arthritis; 58 yoF w/ non-severe COVID-19, (by qRT-PCR ) had arthralgia, fever, cough, nausea, diarrhoea, dysgeusia, and devloped ankle arthritis CRP 7·36 mg/L, lymphopenia (1·29) persistent arthritis (by US) and +Sars-CoV-2 in SF. https://t.co/4Pg1Vq30EN

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Dr. John Cush RheumNow ( View Tweet)

#WomenInMedicine now that we have data from ⁦⁦@NEJM⁩ - how do we help institutions work with women to address these challenges together? https://t.co/kEyegOCfE3
Victoria Shanmugam VickiShanmugam ( View Tweet)
Excellent review of IgG4-RD, @NatRevRheumatol IgG4-RD is indolent (afebrile, etc) but 60% of pts have irreversible damage at dx! Universal response to GC but 40% not in remission at 1yr; B-cell tx can bring about "dramatic response" Good read & topic: https://t.co/Mbrq7bFHk0 https://t.co/8oQF08qzit

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Mike Putman EBRheum ( View Tweet)
Study of 193 Axial SpA pts with TNF inhibitor switching shows, using stringent outcome measures (ASDAS-ID) shows odds of responding to 2nd TNFi best w/ secondary TNFi failure (OR 7.3) or adverse events (OR 9.1), compared to primary TNFi failure. https://t.co/kpDelzBYRe

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Dr. John Cush RheumNow ( View Tweet)

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