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Avacopan - Is it Really a Win for ANCA-Associated Vasculitis?

d Jack Cush, MD

The NEJM has reported the results of a study showing that avacopan, a C5a receptor inhibitor, is as effective as steroids at treating patients with antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV).

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Alveolar Hemorrhage and Mortality in Lupus

d Jack Cush, MD

Metanalysis of patients with diffuse alveolar hemorrhage (DAH), show this to be a rare and life-threatening complication of systemic lupus erythematosus (SLE), that is more apt to affect older, severe lupus patients with active infection.

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Checkpoint Inhibitor Use with Pre-existing Autoimmune Disease

d Jack Cush, MD

Annals of Internal Medicine reports treating advanced melanoma with immune checkpoint inhibitors (ICI) in patients with pre-existing autoimmune disease (AID) was as effective and safe in those with AID compared to those without AID, although severe colitis occurred more frequently among pati

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RWCS Highlights - Day 4

d Rachel Tate, DO

As another year at RWCS in Maui wrapped up, I’m so thankful I had the opportunity to participate remotely. Here are my day 4 #RWCS2021 pearls from the Novel Therapies Year in Review (RA, SLE, OA); novel concepts in pediatric rheumatology; and post-COVID telerheumatology sessions.

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ACR and Three Societies Agree on HCQ Eye Safety

d MedPage Today

Four major medical societies issued a joint statement of principles on safe use of hydroxychloroquine from the perspective of ocular toxicity.

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Email Survey study of HSS rheumatic pts 7,094 responded 1,547 were women (18-50yrs) & 61 (4%) were pregnant during COVID. COVID prevalence was similar in PREG vs nonPREG (8% vs.9% ), PREG COVID pts had shorter Sxs, more loss taste/smell. https://t.co/4HDuXbZVrs

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Dr. John Cush RheumNow ( View Tweet)

2021 RWCS Review podcast is now available- #RWCS Available on SoundCloud and Apple/Android https://t.co/eLk3vqoAT8 https://t.co/U8YjToQlIS

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Dr. John Cush RheumNow ( View Tweet)
QD Clinic - RA and DVT Counseling Patients on JAKs and Thrombotic Risk https://t.co/efQGtkrxHF https://t.co/mfhjZYMlUC

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Dr. John Cush RheumNow ( View Tweet)
Checkpoint Inhibitor Use with Pre-existing Autoimmune Disease https://t.co/S9SQVAKJ8q https://t.co/FOjp2Pk61a

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Dr. John Cush RheumNow ( View Tweet)
Very high levels of IL-18 IL-18 (> 10 000 pg/ml) is associated with Macrophage Activation syndrome (with systemic JIA) as well as primary and secondary Hemophagocytic lymphohistiocytosis (HLH) https://t.co/dotoaYbuPd

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Dr. John Cush RheumNow ( View Tweet)

On March 24, 2021 the FDA Arthritis Advisory Committee and Drug Safety .... Committees will meet online to will discuss biologics license application, for tanezumab, from Pfizer, for the proposed treatment of moderate to severe osteoarthritis in adults https://t.co/NSlutqdHzu

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Dr. John Cush RheumNow ( View Tweet)

Congratulations again to @Tuhina_Neogi, the newly installed Alan S. Cohen Professor of Rheumatology https://t.co/rxWhMOg7w0 https://t.co/vcErMRrvom

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BU/BMC Rheumatology BU_BMC_Rheum ( View Tweet)
Not sure how Lenny wins $50 chanting "Autoantigenomics" - read on anyway... https://t.co/rbghM0PPOl

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Dr. John Cush RheumNow ( View Tweet)

Italian IBD clinic with 90 IBD Vedolizumab Tx pts, 8%(11) developed severe enthesitis (4 Multifocal, 6 unifocal). Sxs after mean 46 wks, CRP=5.1 mg/dl, majority HLA-B27 negative; confirmed by PD/UA in 7 - 4/7 developed post-inflam entheseal calcifications https://t.co/uwAJM8giBX

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Dr. John Cush RheumNow ( View Tweet)

Common mucocutaneous findings in 35 kids w/ MIS-C & COVID: 1) conjunctival injection (21), palmoplantar erythema (18), lip hyperemia (17), periorbital erythema/edema (7), strawberry tongue (8), & malar erythema (6) https://t.co/mcSOXtXaEh

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Dr. John Cush RheumNow ( View Tweet)

RWCS Highlights - Day 4 from Dr. Rachel Tate ( @uptotate) -Novel Therapies Year in Review (RA, SLE, OA) -Novel concepts in Pediatric Rheumatology -TeleRheumatology Update: Post-COVID, Pre-?? https://t.co/JoTV25suxD https://t.co/Id19zgRT37

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Dr. John Cush RheumNow ( View Tweet)
ACR and Three Societies Agree on HCQ Eye Safety Four major medical societies issued a joint statement of principles on safe use of hydroxychloroquine from the perspective of ocular toxicity. https://t.co/3ALK3MpOen https://t.co/SzScNXgoqn

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Dr. John Cush RheumNow ( View Tweet)
MIRROR Study: Pegloticase With Methotrexate in Uncontrolled Gout Botson et al has reported that the combination of methotrexate (MTX) and IV pegloticase is safe and effective in patients with uncontrolled gout. https://t.co/DRkIMOAhs4 https://t.co/2dft1QjC6E

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Dr. John Cush RheumNow ( View Tweet)
30 #RA pts treated w/ tofacitinib x 12 mos w/ signif improvement in DAS28, CRP, & HAQ and attenuation of further bone loss, as measured by significantly increased osteocalcin, OPG, and vitamin D3, with decreased CTX levels correlating w/ DXA results https://t.co/RSXL38cJvs

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Dr. John Cush RheumNow ( View Tweet)

Dr. Lindsey A. Criswell was sworn in this morning as the new director of NIAMS. https://t.co/4LxsX9Lh1W
NIAMS/NIH/DHHS NIH_NIAMS ( View Tweet)
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