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Ustekinumab Early Risk for Cardiovascular Events

d Jack Cush, MD

JAMA Dermatology reports a claims-based, case-time-controlled French study of 9290 psoriasis patients suggesting that ustekinumab initiation may be associated with an increased risk of acute coronary syndrome or stroke in high risk cardiovascular patients.

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Young Adults are Driving Up COVID-19 Rates

d CDC/MMWR

CDC reports that since June 2020 individuals infected with COVID-19 have largely been young adults in the 20-29 year age bracket. Moreover, younger adults appeared to be driving community transmission of COVID-19. 

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Livedo, Purpura and Coagulopathy in Severe COVID-19

d Jack Cush, MD

JAMA Dermatology expands the spectrum of complications seen with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection describing cutaneous purpura and livedo lesions in patients with severe COVID-19.

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CDC Reverses Guidance for Asymptomatic COVID Contacts

d Jack Cush, MD

Asymptomatic people who have been exposed to COVID-19 should be tested, the CDC said on Friday, in a reversal of controversial guidance the agency introduced in late August.

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CXCR3 and Restricted T Cells in Psoriatic Arthritis Inflammation

d Jack Cush, MD

Research from Oxford University suggests a potential pathogenic role for the chemokine CXCR3 and clonally restricted CD8+ T cells in the pathogenesis of psoriatic arthritis (PsA) based studies of PsA synovial fluid samples obtained by arthrocentesis from 11 patients with large-joint oligo Ps

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DMARDs for Early Rheumatoid Arthritis Have Cardiovascular Benefits

d RheumNow

Patients with RA have up to a three-fold increased risk of mortality versus the general population, largely due to an increased incidence of premature CVD, such as atherosclerosis and heart failure.

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FDA has issued a new guidance document outlining the inclusion of geriatric information in drug labeling detect; especially noting geriatic studies and when efficacy and safety differs from that seen in younger adults https://t.co/jTLDae3Gff

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Dr. John Cush RheumNow ( View Tweet)

The EMAs Committee for Medicinal Products for Human Use (CHMP) has recommended baricitinib for approval in adults with moderate-to-severe atopic dermatitis who are candidates for systemic therapy https://t.co/goEacN1C8X

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Dr. John Cush RheumNow ( View Tweet)

Global task force establishes protocols for medical cannabis use to treat pain. Start low (5mg CBD) and titrate up (max 40 mg) - ALL Expert opinion, no good evidence (largely bunk?) https://t.co/HyYU0tGVF5

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Dr. John Cush RheumNow ( View Tweet)

Cluster analysis of 168 antiphospholipid pts shows that having arterial thromboses and cardiovascular risk factors was associated with mortality and poorest prognosis in APS. https://t.co/Nb7lZNu4jT

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Dr. John Cush RheumNow ( View Tweet)

Pain in Knee Osteoarthritis comes from what?

Dr. John Cush RheumNow ( View Tweet)

Questions or Comments to Cush for the RheumNow Podcast? Weigh in with "Back Talk" wherein Ill discuss your question, query and theory https://t.co/Ngg7XyS6ns https://t.co/DuQHfGnXWO

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Dr. John Cush RheumNow ( View Tweet)
Ann Int Med shows again that steroids increase serious infection risk in a dose dependenet manner, but even 5 mg of prednisone or less also gives a small but significant risk of serious infection in RA patients on DMARDs (claims data from Medicare & Optum) https://t.co/bj41SqKP0K

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Dr. John Cush RheumNow ( View Tweet)

A machine-learning algorithm was developed using MRI data from the Osteoarthritis Initiative capable of predicting osteoarthritic progressors from baseline cartilage texture maps ; Had a test accuracy of 78% in detecting OA progression 3 y prior to Sxs https://t.co/OPw9KGb4jr

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Dr. John Cush RheumNow ( View Tweet)

Outcomes survey of 229 relapsing polychondritis patients shows that 59% had auricular-onset (AO) and 21% had respiratory -onset (RO), 20% w/ miscellaneous-onset (MO- eye MSK CNS). Poorer prognosis seen in RO & MO subgroups than AO subgroups https://t.co/rzVU42z3EA

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Dr. John Cush RheumNow ( View Tweet)

6.6% Risk of Late-onset Neutropenia (ANC<1000) in a single center study of 738 Rx w/ Rituximab (107 LON in 71 patients). Incidence was 7.2/100PYs. Higher risk w/ SLE or CTX Rx. 40% had Sxs, Fever 31%, sepsis in 8.5%. Rechallenge in 87% & 21% recurrent LON https://t.co/XXFV1lH9jS

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Dr. John Cush RheumNow ( View Tweet)

Metanalysis presented at European Association for the Study of Diabetes (EASD), involving 1,629,854 participants and found #RA was associated with a 23% higher chance of developing T2D, compared to the diabetes risk within the general population https://t.co/Qff7gpzves

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Dr. John Cush RheumNow ( View Tweet)

As of 20 Sept, CDC reports total US COVID-19 deaths to be 198,754. In the last 7 days 281,490 new Cases. Trends flat averaging ~40,000 Cases per day and ~600-1100 deaths per day. https://t.co/CPLVhz6qeH

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Dr. John Cush RheumNow ( View Tweet)

In our September issue—Symmetric peripheral polyarthritis developed during SARS-CoV-2 infection https://t.co/IqHp2GMLao https://t.co/Prvw8OBTvH

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The Lancet Rheumatology TheLancetRheum ( View Tweet)
Lisa Sammaritano, MD, stresses that there must be communication between rheumatologists and OB-GYNs when it comes to addressing pregnancy for #rheumatology patients. #CCREast https://t.co/j1IH6gsKnk

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HCPLive MDMagazine ( View Tweet)

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