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EULAR 2024 - Day 1 Report
Wednesday was Day One at EULAR 2024 in Vienna. While the day was a slow start, the poster halls and auditoriums quickly filled with thousands of rheumatologists, eager to reunite at this international educational forum. Below are a few of my favorites from Day 1.
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EULAR 2024: New drugs for RA?
Several abstracts are presenting new compounds, targeting either RA well-known inflammatory pathways or offering new mechanisms of action or therapeutic sequences; these are summarized below.
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How can we predict the 1/3 of palindromic rheumatism patients who will go on to develop persistent inflamm arthritis?
Easy to use score derived from 15y data from @UniversityLeeds - can exclude the low-risk so they don’t need to be followed.
#EULAR2024 OP0127 @RheumNow https://t.co/gB0FpUPOFC
Links:
David Liew drdavidliew ( View Tweet)
OP0131 on occurrence & predictors of #DMARD treatment failure in #RA
8% of pts failed ≥3 b/tsDMARDs with ~4yrs to failure
In pts starting first b/tsDMARD, up to 25% fail ≥2 b/tsDMARDs in 3yrs
Risk of fulfilling EULAR D2T criterion 1 ➡️ 2.3% in first 5yrs
@RheumNow #EULAR2024
Mrinalini Dey DrMiniDey ( View Tweet)
🗣️Abstract session on difficult-to-treat #RA kicks off with OP0118 on predictors of D2T RA
📈Female sex, high joint count, erosions, pulmonary #comorbidities, depression & fatigue assoc with D2T RA
💊MTX after start of advanced therapy protective of D2T RA
@RheumNow #EULAR2024
Mrinalini Dey DrMiniDey ( View Tweet)
GC treatment duration for <90 and 90 to 360 days is associated with a higher risk of cumulative SI compared to nonexposed, especially the first year but also up to two years since first visit in RA patients. Maximum RR for <90 days is observed at 8 months since first visit (RR:… https://t.co/ecK2ylqrRk https://t.co/IQ5QQjExYQ
Links:
Dr. Antoni Chan synovialjoints ( View Tweet)
Poster tours at #EULAR2024.
A third of seropositive RA patients with long disease duration had subclinical lung abnormalities. This pilot study showed the potential role of lung ultrasound for the screening of subclinical ILD among these patients. Abstract 070 @RheumNow https://t.co/ypAh4idV3j
Dr. Antoni Chan synovialjoints ( View Tweet)
OP0072 @RheumNow #EULAR2024
Effects of #Upadacitinib or #Adalimumab on pain in #RA
SELECT-COMPARE Phase 3 study
UPA & ADA led to improvements in pain vs PBO
PtGA & TJC28 pain improvement similar between UPA & ADA
➡️ UPA may be more effective in control of pain than ADA in RA
Mrinalini Dey DrMiniDey ( View Tweet)
#Vaccinations against #herpes #zoster in #MTX +#Upadacitinib Pts
▶️ #Shingrix works
👍Pts followed to 60 months
#EULAR2024
@eular_org @RheumNow
#OP0020 https://t.co/8ORC3Nd2FK
Janet Pope Janetbirdope ( View Tweet)
OP0018 @RheumNow #EULAR2024
🔎 Study looked at early RA patient trajectories through time-independent disease state
📊 Authors demonstrated 4⃣ trajectories in early RA
🦴 Inflammation in joints, blood & poor response are main discriminatory factors https://t.co/IeDIU3jg9B
Mrinalini Dey DrMiniDey ( View Tweet)
➡️ OP0064 @RheumNow #EULAR2024
➡️ Non-articular pain (NAP) at early RA diagnosis & evolution over the first yr of RA treatment
➡️ NAP, esp regional NAP, common in early RA during 1st yr
➡️ NAP in axial, both upper quadrants and both lower quadrants common https://t.co/FOGcS05Z25
Mrinalini Dey DrMiniDey ( View Tweet)
OP0086 #EULAR2024 @RheumNow #EULARBest
Pain & remission/low disease activity at 3m in pts with #RA in RA-BE-REAL
Pts taking #baricitinib more likely to achieve pain control vs TNFi/other mode of action
1/2 pts achieving remission/LDA & had bari achieved ≥70% pain relief.
Mrinalini Dey DrMiniDey ( View Tweet)
TOLERA trial in RA
RTX/ABA sequence versus RTX alone
10pts each group
Primary outcome was ambitious: ACPA seroconversion
No difference between ttmts (and also no seroconversion)
No diff in disease activity
No diff in ACPA change wt wk52
@RheumNow OP0069 #EULAR2024 https://t.co/0EM7XRzfNo
Aurelie Najm AurelieRheumo ( View Tweet)
AMPLIFIED RCT, 300+ pts
ABA NOT (!) superior to ADA
in dual seropositive SE+ MTX IR RA pts
ACR50 rate high in both gps ABA 59% vs ADA 64%
No new safety signal
Defeating the encouraging data from smaller trials
Abstr#OP0007 #EULAR2024 @RheumNow https://t.co/PvRUnpthHl
Aurelie Najm AurelieRheumo ( View Tweet)
Reminder of relevance of #Rheumatoid factor
⬆️RF also predicts
cardiovascular events ⚠️
⬆️disease activity
❗️Worse outcomes
#EULAR2024 #RF #RA https://t.co/kXwh682ONp
Dr Gurdeep S Dulay gurdeep_dulay ( View Tweet)
What is new in RA at #EULAR2024?
Below 👇🏻 my article summarising some of the exciting new MoA, therapeutic strategies and drugs that might (or not) shape RA future!
https://t.co/ttYdElWlBY
@RheumNow
Links:
Aurelie Najm AurelieRheumo ( View Tweet)
🚨New(ish) MoA in RA
Abiprubart anti-CD40 mAb
Blocks T cell activation
Reduction DAS28-CRP Wk 12 -2.2 vs. -1.6 PBO
Small sample n=25 per gpe
Safety profile acceptable
To be continued...
Abstr#OP0036 #EULAR2024 @RheumNow https://t.co/su4L7A7nGJ
Aurelie Najm AurelieRheumo ( View Tweet)
Substudy of SELECT-COMPARE trial
Week 60 immunogenicity RZV RA treated UPA 15 mg + MTX
✔️ HUmorale response 71%
✔️ Cellular response 65%
✔️ No serious AEs
✔️ One event of HZ occurred during follow up
Abstr#OP0020 #EULAR2024 @RheumNow https://t.co/8OMwGuIZFx
Aurelie Najm AurelieRheumo ( View Tweet)
Novel B cell depleters! Bispecific T cell engagers (BiTEs) being studied for #SLE & #RA as a way to get CAR-T cell like responses but more accessible w/less risk for CK release syndrome. #EULAR24
T cell-engaging therapies — BiTEs and beyond | Nature Reviews Clinical Oncology
TheDaoIndex KDAO2011 ( View Tweet)
Nordic country analysis of mortality in RA (n 1145), RA-ILD (239), population ILD (378) & nl controls (1890) shows most mortality in pop ILD (HR 8.3), but less in RA-ILD (HR 3.6). Why is death less in latter; could it be RA therapies? Abstr #POS0022 # EULAR2025 https://t.co/wFZq49rIiW
Dr. John Cush RheumNow ( View Tweet)
