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Tofacitinib Effective in Refractory Still's Disease

d Jack Cush, MD

Fourteen cases reported from mainland China suggest that tofacitinib (TOFA) may be effective in patients with refractory adult-onset Still’s disease (AOSD), further adding to a growing list of potential use of JAK inhibition in managing inflammatory, and now autoinflammatory, disease.

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Seronegativity on the Rise in RA

d RheumNow

Although the overall incidence rates of rheumatoid arthritis (RA) have remained stable over recent decades, there has been a significant increase in seronegative cases, a retrospective study showed.

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JAK Inhibitors Stimulate Osteoblasts

d Jack Cush, MD

Science Translational Medicine has a report on how the use of Janus kinase (JAK) inhibitors may boost osteoblasts to battle bone erosions in conditions like rheumatoid arthritis (RA).

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Adverse Effects of Low-Dose Methotrexate from the CIRT Trial

d Jack Cush, MD

Low-dose methotrexate (LD-MTX) was studied in high risk cardiac patients in the cardiac intervention trial (CIRT), but was prematurely ended for not showing a change in cardiovascular event rates. Nonetheless this trial studied the safety and adverse event rates of LD-MTX and those results are reported in the current issue of Annals of Internal Medicine.

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BSR Guidelines for Giant Cell Arteritis

d Jack Cush, MD

NICE has commissioned an update to the 2010 British Society for Rheumatology guideline for the management of giant cell arteritis, and proposed a total of 19 recommendations for the diagnosis and treatment of GCA.

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Primary Care Visits Decline 2008-2016

d Jack Cush, MD

A national claims-based analysis has shown a consistent decline, by commercially insured adults (18-64 yrs), in primary care physician visits from 2008 to 2016; with nearly one half having no PCP visits in a given year by 2016. 

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Dr A Reimold @UTSWIMchief @RheumNow on SpA Risks for SpAprogression https://t.co/5ETqFSa54s
k dao KDAO2011 ( View Tweet)
QD Clinic - Dosing RTX and Remicade - listen to the podcast on iTunes or here https://t.co/MXNZ9uqBWE

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"Courage is what it takes to stand up and speak; courage is also what it takes to sit down and listen." - Winston Churchill

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Important acronyms in both Ortho and Rheum. Dr Wm Bugbee at #RWCS2020 @RWCSmtg https://t.co/guqjPwkoFT
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QD Clinic - Same Day? Outpatient Hip Replacements? Really? Listen on iTunes or here https://t.co/yinzgxyLgt

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QD Clinic - CPPD and PIP4 - listen to the podcast on iTunes or here ttps://bit.ly/2SVyULW

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A study of 319 WOMEN with RA shows a higher rate of depression (30% in RA) compared to healthy controls (12.4%) (p<0.001). Depressive symptoms were strongly associated with disease activity and disability (HAQ, p<0.005). https://t.co/JDRNrR8qMn

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"Success is not final, failure is not fatal: it is the courage to continue that counts." - Winston Churchill

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Pregnancy study from Alberta compared population with (308,989), RA (631), SpA (2461) - showed RA more likely to be complicated by preterm delivery (13.5%), C-section (34%), HTN in preg (10.5%), and SGA (15.6%). No incr found in SpA women https://t.co/c3WkCVOg4e

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Slovenian National TB Registry (a non-endemic area w/ TB rate 6/100k similar to US). 2429 TNFi exposed (RA, AS, PsA)-6% required TB chemoprophylaxis; 6 RA and 2 PsA developed TB; 2 pts died. The TB incidence rate for TNF Rx pop was 45-51/100kPYs https://t.co/tam5I17QO1

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FDA has approved OTC voltaren (diclofenac) gel, now called Voltaren Arthritis Pain for arthritis & OA pain; it is not for immediate relief and may take up to 7 days to work. Pts should seek medical attention If they need to use this product for >21 days. https://t.co/qTcbPZDcqa

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"In the course of my life, I have often had to eat my words, and I must confess that I have always found it a wholesome diet." -Winston Churchill

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THe QD Clinic compilation Podcast 70-72 https://t.co/F11j7F4tZZ

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RheumNow Podcast is up! Cool stuff and quips from the RWCS meeting! Watch the video here https://t.co/F8tS8nkLLB or listen to it on iTunes or here https://t.co/F11j7F4tZZ

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Dr. John Cush RheumNow ( View Tweet)

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