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Treatment of Statin-induced anti-HMGCR myopathy

d Jack Cush, MD

Statin-induced myositis, often with anti-HMGCR autoantibodies can be difficult to manage, Arthritis Research & Therapy yhas published the experience of 55 patient with HMGCR myopathy, demonstrating that while steroid management may be reasonable in select patients, the use of tr

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RheumNow Podcast- Knee Pain Knockout (1.10.20)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com. The podcast covers: best therapies for dactylitis and enthesitis; we have a new knockout for knee pain in OA; and are you on the naughty or nice list when it comes to the new ACR-AF guidelines for arthritis? This and more. Tune in.

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Best Practice Recommendations in Musculoskeletal Care

d Jack Cush, MD

A group of Western Australian clinicians have set out to assess current practices and proved guidance recommendations for high-quality care for the most common musculoskeletal (MSK) pain scenarios encountered by clinicians in emergency and primary care.

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Genicular Artery Embolization to Treat Osteoarthritis Knee Pain

d Jack Cush, MD

A study from the Journal of Vascular and Interventional Radiology has shown that  knee pain secondary to osteoarthritis (OA) may be effectively treated by selective vascular interruption (embolization) showing efficacy and safety in a small pilot trial. 

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ACR 2018 - Day 3 Report

d RheumNow

Highlights from Tuesday, day 3 of the ACR Annual meeting in Chicago, included the PEXIVAS Study, ACR Reproductive Health Draft Guidelines, and a Proof of concept study

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RheumNow Podcast is up! Oral Vs IV Abx, Drugs for Dactylitis/Enthesitis, Arterial embolization for OA; watch here>> https://t.co/GkpOmT4uSZ or Listen on Apple podcasts or here >> https://t.co/a2KtwRjkOY

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Among 1827 SLE pts, 52.3% had neuropsychiatric (NP) events attributed to SLE. In first 2 years the relative risk for SLE NP events was 6.16. Mortality was higher with NP events attributed to SLE (16%) versus no NPSLE events (6%) https://t.co/uCx5Uf9kJj

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UK study of 2701 Early arthritis pts Dx in 3 different eras finds that from those dx in 2010, 59% were estimated to reach low disease activity compared with 48% with diagnosis in 2002 and 32% with diagnosis in 1990. https://t.co/rn2cYLID6V

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JAMA Case challenge: 61yoM with seronegative RA x yrs (rx w/ MTX and biologics) develops intermittent fever (38C), asymmetric polyarthralgias, & 50 lb Weight Loss, CRP 7.7mg/L. No response to TCZ and developed diarrhea. What do you do next? https://t.co/QkGca1qp9r

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Dr. Heidi Jacobi #UTSW lecturing on PSS skin disease Tx algorithm published in A&R. CTX has clearly dropped off https://t.co/l4fj8UzrtU
Dr. John Cush RheumNow ( View Tweet)
Dr. Heidi Jacobi #UTSW lecturing on PSS. Other options for refractory dz include IVIG, RTX, TCZ, ABA and uVA1 therapy https://t.co/sn2sqXTFSN
Dr. John Cush RheumNow ( View Tweet)
Study of 1054 adults with septic bone, joint, prosthetic infections shows that 6 weeks of oral antibiotic therapy cost less and was noninferior to IV antibiotic therapy (success rate ~85% at 1 year) while being >20% cheaper https://t.co/MYNxAWT1GT

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Dr. Heidi Jacobi #UTSW MMF maybe an alternative to MTX, but only has observational evidence https://t.co/6yzFCdgE6S
Dr. John Cush RheumNow ( View Tweet)
Dr. Heidi Jacobi #UTSW shoes data that MTX works in SSc https://t.co/CzOmeg2ant
Dr. John Cush RheumNow ( View Tweet)
Dr. Heidi Jacobi #UTSW says limited SSc has slowly progressive skin thickening of the distal extremities but also the face and neck.

Dr. John Cush RheumNow ( View Tweet)

Dr. Heidi Jacobi #UTSW says the telangiectasias of CREST are usually a late, not early, finding

Dr. John Cush RheumNow ( View Tweet)

Dr. Heidi Jacobi #UTSW says Raynauds, puffy digits and a +ANA should raise suspicion of systemic sclerosis. Also Carol tunnel syndrome may be a presenting feature

Dr. John Cush RheumNow ( View Tweet)

Dr. Heidi Jacobi #UTSW lecturing on scleromyxedema often with "pebble like" lesions that during it from scleroderma https://t.co/5odVXrglyT
Dr. John Cush RheumNow ( View Tweet)
#UTSW Rheumatology grand rounds with Dr Heidi Jacobi . Serologic and lab findings in patients with MOPHEA https://t.co/d619QnYrZ9
Dr. John Cush RheumNow ( View Tweet)
Toscana is an arbovirus transmitted by sand flies in the Mediterranean. May fever, neuroinvasive infections & is an important cause of meningitis and encephalitis. May also cause Guillain-Barré, myositis, fasciitis, polymyeloradiculopathy, deafness, https://t.co/9X4OwAqRF9

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