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Steroid-Sparing Effect of Tocilizumab in Refractory Takayasu Arteritis

d Jack Cush, MD

A controlled clinical trial has shown that giving the IL-6 receptor antibody, tocilizumab (TCZ), to  patients with Takayasu arteritis (TAK) results in clinical efficacy and has a steroid sparing efffect.

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CDC: 15% of US Adults are Physically Inactive

d Jack Cush, MD

All states and territories had more than 15% of adults who were physically inactive and this estimate ranged from 17.3 to 47.7%,  according to new state maps of adult physical inactivity prevalence released today by the Centers for Disease Control and Prevention (CDC).

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RheumNow Podcast- The Down Side of Steroids (1.17.20)

d Jack Cush, MD

Dr. Jack Cush reviews the journal reports and news from RheumNow.com.
Be sure to register for RheumNow Live 3/13/2020 in Fort Worth
Rheumnow.live.

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NSAID Safety Guidelines

d Jack Cush, MD

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for acute or chronic arthritis, headache, visceral pain, postoperative pain, etc but come with a small but significant risk of serious adverse effects, including hypertension, cardiovascular disease, kidney injury and GI complica

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TULIP2 - Anifrolumab Succeeds in Lupus

d Jack Cush, MD

NEJM has published the results of the TULIP2 trial with anifrolumab, an alpha interferon blocker, in the treatment of systemic lupus erythematosus, showing significant improvement (over placebo) in multiple lupus outcome measures, including BICLA, SRI-4, CLASI and others.

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Poor Sleep Increases Risk of Cognitive Decline

d Jack Cush, MD

The Journal of Neurology, Neurosurgery & Psychiatry reports there is moderate evidence that six sleep disorders (insomnia, fragmentation, daytime dysfunction, prolonged latency, rapid eye movement sleep behaviour disorder and excessive time in bed) significantly increases the ri

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Should We Screen Younger Postmenopausal Women for Osteoporosis?

d Jack Cush, MD

Do postmenopausal women, under age 65 years, need a baseline BMD testing? A JAMA Insights review suggests that the absolute risk of fracture is low in this group and that USPSTF guidelines should be considered - that we should be screening women younger than 65 years who are at increased risk of osteoporosis and we should be using a formal risk assessment tool to identify candidates for bone density testing.

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#MLK - “If you can’t fly then run, if you can’t run then walk, if you can’t walk then crawl, but whatever you do you have to keep moving forward.” - Martin Luther King Jr.

Dr. John Cush RheumNow ( View Tweet)

#MLK "Everybody can be great … because anybody can serve. You don’t have to have a college degree to serve. You don’t have to make your subject and verb agree to serve. You only need a heart full of grace. A soul generated by love.” - Martin Luther King

Dr. John Cush RheumNow ( View Tweet)

The driving force behind @RheumNow profiled in this article. Thanks for taking the time Jack https://t.co/T4nWMLDYFL

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Dr Irwin Lim _connectedcare ( View Tweet)

RheumNow Podcast is up! S ame day hip replacments? Steroids & organ damage; Watch it here>> https://t.co/QY3qxTEYv0 or listen to the podcast in your car on Android Auto, Apple car play or https://t.co/3aCQ6qEJPx

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Dr. John Cush RheumNow ( View Tweet)

The future is bedside-to-bench: "Systemic comparison (of immunotherapy irAEs) with canonical forms of (inflamm arthritis)... may shed novel insights into the development of IA more broadly and identify common mechanisms and targets for therapy" @cappelliMD https://t.co/zYZyUFx8KU

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David Liew drdavidliew ( View Tweet)

Thanks to Irwin and Rheuma Republic for this generous bio and profile of yours truly. RheumNow gives me a daily chance to spread the wealth or to get it right! https://t.co/gvQf5sUF3m

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Dr. John Cush RheumNow ( View Tweet)

Attending the annual ASAS meeting in Houston and hearing about the development of new platforms to disseminate information on #spondyloarthritis #axialspondyloarthritis https://t.co/uqDxbkHX7N

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Dr. Antoni Chan synovialjoints ( View Tweet)

The RheumNow Podcast is up! Steroids and organ damage; same day hip replacments? Tulips and d-Dimers. Watch in on RheumNow>> https://t.co/QY3qxTEYv0 or listen to the podcast in your car on Android Auto, Apple car play or https://t.co/3aCQ6qEJPx

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Dr. John Cush RheumNow ( View Tweet)

23% of RA patients have moderate-to-severe Obstructive Sleep Apnea (AHI ≥ 15) - study of RA patients 199 patients underwent PSG, OSA is more common in RA than in the general population, but there is no relationship with disease activity. https://t.co/noojvYmtMk

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Dr. John Cush RheumNow ( View Tweet)

Analysis of worldwide data on Abatacept shows that compared with other bDMARDs, ABA was not associated with an increased overall cancer risk [ROR 0.98 (95% CI 0.91, 1.05)], but may be increased for risk of melanoma [1.58 (95% CI 1.17, 2.08)] https://t.co/3EI52M5kIR

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Dr. John Cush RheumNow ( View Tweet)

Actress Tatum O'Neal, 56, was diagnosed with rheumatoid arthritis at age 50, but had symptoms for almost 10 years. https://t.co/DotJHTLU3h

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Dr. John Cush RheumNow ( View Tweet)

MIRROR OL study shows that when pegloticase is co-administered with methotrexate, a high rate of response is seen (79% or 11/14 pts), achieved a complete response (sUA < 6 mg/dL) at Month 6. Topline results announced by Horizon. https://t.co/PY61xSoaxY

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Dr. John Cush RheumNow ( View Tweet)

Study of 224 pregnancies (133 women) w/ UCTD, ANA+, <45 yrs. The outcomes: live births 79%, 20% miscarriages, 0.9% stillbirths and 2.7% intrauterine growth restriction. Miscarriages & stillbirths strongly associated with aPL and ENA antibodies (P < 0.05). https://t.co/pvtneDW5In

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Dr. John Cush RheumNow ( View Tweet)

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