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Diabetics using SGLT2 Inhibitors have a lower Gout Risk

d Jack Cush, MD

Researchers from the Brigham and Women's Hospital have reported that adults with type 2 diabetes who were treated with SGLT2 inhibitors had a lower risk of gout compared to GLP1 agonist, suggesting that sodium–glucose cotransporter-2 inhibitors may reduce the risk for gout with type 2 diabetes mellitus (T2DM).

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Rheumatologists Ranked #1 in Happiness (Again)

d Jack Cush, MD

Medscape has reported the results of its 2020 annual physician survey, This year rheumatologists (60%), general surgeons (60%), public health and preventive medicine physicians, and allergists/immunologists are the "happiest" outside of work compared to other specialists, according to Medscap

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Steroids Up the Risk of Organ Damage in SLE

d Jack Cush, MD

Lancet Rheumatology has reported the results of a multicenter follow-up study of systemic lupus erythematosus (SLE) patients showing that organ damange is linked to glucocorticoid use, independent of clinical or serological disease activity.

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Treatment of Statin-induced anti-HMGCR myopathy

d Jack Cush, MD

Statin-induced myositis, often with anti-HMGCR autoantibodies can be difficult to manage, Arthritis Research & Therapy yhas published the experience of 55 patient with HMGCR myopathy, demonstrating that while steroid management may be reasonable in select patients, the use of tr

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RheumNow Podcast- Knee Pain Knockout (1.10.20)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com. The podcast covers: best therapies for dactylitis and enthesitis; we have a new knockout for knee pain in OA; and are you on the naughty or nice list when it comes to the new ACR-AF guidelines for arthritis? This and more. Tune in.

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Best Practice Recommendations in Musculoskeletal Care

d Jack Cush, MD

A group of Western Australian clinicians have set out to assess current practices and proved guidance recommendations for high-quality care for the most common musculoskeletal (MSK) pain scenarios encountered by clinicians in emergency and primary care.

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Genicular Artery Embolization to Treat Osteoarthritis Knee Pain

d Jack Cush, MD

A study from the Journal of Vascular and Interventional Radiology has shown that  knee pain secondary to osteoarthritis (OA) may be effectively treated by selective vascular interruption (embolization) showing efficacy and safety in a small pilot trial. 

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Same-day discharge arthroplasty (usually w/in 4-8 hrs after surgery) may be a feasible, made possible by \minimally invasive surgery, tranexamic acid & multimodal analgesia. CMAJ review contraindications: Age >80yrs, cirrhosis, CKD, bleeding disorders https://t.co/KzO6faH3sw

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Rifampin is safest! 2 RCTs of 6485 latent TB pts compared 9 mos of isoniazid vs 4 mos of rifampicin. RIF had half the adverse events compared to INH; roughly half the rate of rash (1.5% v 2.7%); No grade 3-4 hepatotoxicity w/ RIF, compared 6%) w/ INH https://t.co/i3eONh5wMk

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NHANES survey shows that about 1 of 5 adolescents and 1 of 4 young adults have prediabetes; higher in males and the obese. https://t.co/tyebscVjkr

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The modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) has been validated as the most widely used assessment of Xray progression in AS, correlating with measures of disease activity, spinal mobility & physical function (over 2-years) https://t.co/UqKSJ7SZDC

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Dr Kevin Winthrop has published claims analyses showing nontuberculous mycobacterial infections are increasing- from 3.13 to 4.73/100,000PY & prevalence from 6.78 to 11.7/100,000PYs (from 2008 to 2015), esp in women & elderly https://t.co/IuXQACC9eE

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128 pts w/ Breast Cancer were evaluated for rheumatic complaints. Ultimately 1/3 developed an inflammatory rheumatic disease; most common being RA (8%), Sjogrens (6%) & PsA (5%). Arthralgias were more common with aromatase inhibitor use. https://t.co/d9CqWfRrXD

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RheumNow Podcast is up! Oral Vs IV Abx, Drugs for Dactylitis/Enthesitis, Arterial embolization for OA; watch here>> https://t.co/GkpOmT4uSZ or Listen on Apple podcasts or here >> https://t.co/a2KtwRjkOY

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Among 1827 SLE pts, 52.3% had neuropsychiatric (NP) events attributed to SLE. In first 2 years the relative risk for SLE NP events was 6.16. Mortality was higher with NP events attributed to SLE (16%) versus no NPSLE events (6%) https://t.co/uCx5Uf9kJj

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UK study of 2701 Early arthritis pts Dx in 3 different eras finds that from those dx in 2010, 59% were estimated to reach low disease activity compared with 48% with diagnosis in 2002 and 32% with diagnosis in 1990. https://t.co/rn2cYLID6V

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JAMA Case challenge: 61yoM with seronegative RA x yrs (rx w/ MTX and biologics) develops intermittent fever (38C), asymmetric polyarthralgias, & 50 lb Weight Loss, CRP 7.7mg/L. No response to TCZ and developed diarrhea. What do you do next? https://t.co/QkGca1qp9r

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Dr. Heidi Jacobi #UTSW lecturing on PSS skin disease Tx algorithm published in A&R. CTX has clearly dropped off https://t.co/l4fj8UzrtU
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Dr. Heidi Jacobi #UTSW lecturing on PSS. Other options for refractory dz include IVIG, RTX, TCZ, ABA and uVA1 therapy https://t.co/sn2sqXTFSN
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Study of 1054 adults with septic bone, joint, prosthetic infections shows that 6 weeks of oral antibiotic therapy cost less and was noninferior to IV antibiotic therapy (success rate ~85% at 1 year) while being >20% cheaper https://t.co/MYNxAWT1GT

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