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Fewer Lupus Flares on Low Dose Steroids

d Jack Cush, MD

French researchers have shown that patients with systemic lupus erythematosus (SLE) and inactive disease are less likely to flare while taking a 5 mg prednisone maintenance dose.

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Obesity Not Discussed by Doctors and Patients

d Jack Cush, MD

Reuters -  Doctors rarely talk about weight concerns with patients who are overweight or obese, and when they do, patients’ experiences tend to be negative, according to a new review of research based on interviews.

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A Role for SGLT2 Inhibition in Gout?

d RheumNow

The antidiabetic medication canagliflozin (Invokana) lowered serum urate and reduced the risk of gout flare in a post-hoc analysis of data from two large clinical trials.

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Domestic Abuse Linked to Fibromyalgia and Chronic Fatigue

d Jack Cush, MD

Domestic violence was found to predispose to a higher risk of fibromyalgia and those developing chronic fatigue syndrome.

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No Cancer Risk with Systemic Necrotizing Vasculitis

d Jack Cush, MD

The French Vasculitis Study Group has published that patients with systemic necrotizing vasculitis do not have an increased risk of malignancy; in fact they have a risk that is similar to the general population.

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Predicting Inpatient Gout Flares

d Jack Cush, MD

Analysis of New Zealand hospitalized patients revals nine predictors of inpatient flare for people with comorbid gout.



This retrospective cohort study of hospitalised patients with comorbid gout included 625 hospitalised patients, 87 experienced inpatient gout flare.

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RheumNow Podcast - The Elusive Hand OA Problem (12.13.19)

d Jack Cush, MD

Dr. Jack Cush recaps the news and journal reports from the past week on RheumNow.com.

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Early Lupus study of 230 pts -Assess by SLICC/ACR Damage Index - 22% had Damage Index ≥1 after 12 months, 26% qt 2 yrs and 29%) @ 3 yrs. Risk factors included Dyslipidaemia (HR 2.9), older age (3.0), #organs/systems (1.4), CVresp Dz (1.9) https://t.co/JUrgTN5hII

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Dr. John Cush RheumNow ( View Tweet)

Why are we guessing? A 20 yr #RA pt, Severe, erosive, polyarticular CCP+ RA, failed MTX, SSZ, Enbrel, Humira, Cimzia, Xeljanz, Orencia; had TJC 22, SJC 18, CDAI 37; put on LEF & IL-6 inhib & 2 mos later SJC 2, CDAI 3! HELP! We need a better way! AI #bigdata, #realbiomarkers

Dr. John Cush RheumNow ( View Tweet)

In Southern Sweden, the prevalence of non-gout crystal arthropathy (>1/3 of which was CPPD) is 0.23%, w/ meage of 71 yrs, more in men and increases w/ age. The incidence is 21.5 (19–25) cases/100,000 persons. https://t.co/MLIhxBPUSO

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Dr. John Cush RheumNow ( View Tweet)

Should AS/SpA pts have ECHO for AI/AR? I say YES; Swedish study of 6448 AS pts shows 2 fold higher risk AI https://t.co/lchlsGXAJi. Another ECHO study 187 AS pts shows an incr prevalence (18%) of AI murmur esp w/ longstanding disease or age >50 (>50%) https://t.co/Np21FwCbBP

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Dr. John Cush RheumNow ( View Tweet)

There is a 2 fold higher rate of RE-Vertebral fractures in Primary Osteoporosis patients who had a previous percutaneous vertebroplasty (PVP) and when taking steroids (vs no steroids). https://t.co/rQaqZnmaD5

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Dr. John Cush RheumNow ( View Tweet)

retrospective cohort study of CCP+ individuals without RA, were followed, showing that they were more likely to progress to RA in 5 yrs if they had high CCP antibody levels (46%). (HR 4.83 [95% CI 2.51–9.31]) https://t.co/Vuaqly1M5Y

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Dr. John Cush RheumNow ( View Tweet)

From 2007 to 2018, claims for Lyme disease increased nationally 117%, from 0.027% of all medical claims to 0.058%. Most affected states were New Jersey, Rhode Island, Connecticut, Massachusetts and New York https://t.co/v4XF97O0bU

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Dr. John Cush RheumNow ( View Tweet)

Retrospective cohort study of 154 RA patients undergoing 244 major surgeries in shows that perioperative use of DMARDs (39%) or biologics (13%) was not associated with 30-day odds of post-operative infection #ACR19 Abst #1805 https://t.co/7poDnUhRNf

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Dr. John Cush RheumNow ( View Tweet)

FDA has approved Xeljanz XR (tofacitinib) extended-release 11 mg and 22 mg tablets for the once-daily use in moderately to severely active ulcerative colitis (UC), after an inadequate response or intolerance to TNF blockers. https://t.co/L9lcHfosU1

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Dr. John Cush RheumNow ( View Tweet)

The RheumNow Podcast is up - The Elusive Hand OA Problem (12.13.19) Watch it here>> https://t.co/l75xB48JqW or listen to the podcast here >> https://t.co/hLChtsUSdu

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Dr. John Cush RheumNow ( View Tweet)

Great Full Text, Full Read review of obstructive sleep apnea in 12/3/19 Annals of Internal Medicine Mild OSA: AHI or REI ≥5 but <15 events/h Moderate OSA: AHI or REI ≥15 but <30 events/h Severe OSA: AHI or REI ≥30 events/h https://t.co/nwNwejhLCn

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Dr. John Cush RheumNow ( View Tweet)

YET another drug fails in erosive hand OA (EHOA). A phase II trial of an IL-1 inhibitor (lutikizumab) vs PBO given to 110 EHOA pts shows not differences in pain outcomes, despite biologic changes in CRP, IL1, neutrophils in those on the IL-1 inhibitor. https://t.co/i2N4vs0Sjb

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Dr. John Cush RheumNow ( View Tweet)

More than half of all US physicians recommend complementary health approaches (CHAs) to their pts - Most rec: massage therapy 30%, chiropractic/osteopathic manipulation 27%, herbs/supplements 26%, yoga 26% and acupuncture 22%. https://t.co/eyiU3LbNLN

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Dr. John Cush RheumNow ( View Tweet)

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