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Dr. West’s #ACR19 pearls. Idiopathic orbital inflammation- think sarcoid, vasculitis, igG4-get biopsy. In IgG4 hypocomplementemia implies renal involvement, LN bx not useful but may also help rule out lymphoma or infection. @RheumNow
Dr. Rachel Tate uptoTate ( View Tweet)
Results from2 anti-IL-17 agents Secukinumab and Ixekizumab in non-radiographic axial Spondyloarthritis poster #L2 and abstract #2729 is promising as treatment options for patients #ACR19 @RheumNow
Dr. Antoni Chan synovialjoints ( View Tweet)
The ASAS40 and all major secondary endpoints for Ixekizumab Q4W and Q2W were met at Wk 16 and Wk 52 with no unexpected safety findings. IXE superior to PBO for improving signs, symptoms, and inflammation on MRI in pts with nr-axSpA abstract #2729 #ACR19 @RheumNow
Dr. Antoni Chan synovialjoints ( View Tweet)
#ACR19 - AM session re:classification vs diagnostic criteria, referencing 2016 Sjogrens Guidelines
1. Designed for rsrch
2. May miss important cases (lower sensitivity)
3. Not intended for diagnosis
Remember this when using them in practice! @RheumNow
https://t.co/KHWyVYjOjM https://t.co/xyOpkh9mSC
Mike Putman EBRheum ( View Tweet)
Killed zoster vaccine was safe with no flare of RA and PsA We need to know if response was good. #ACR19 @RheumNow abst2093 https://t.co/xp2Ju5wZWK
Janet Pope Janetbirdope ( View Tweet)
Do you combine bDMARD with apremilast? #ACR #ACR19 @RheumNow abstract 1481
Janet Pope Janetbirdope ( View Tweet)
retrospective study using Medicare claims data demonstrates lower risk of infection-related hospitalization with abatacept compared to other biologics, in RA patients previously exposed to TNFi. Abstr#1801 #ACR19 @RheumNow
Cassandra Calabrese CCalabreseDO ( View Tweet)
ICIR data showing Checkpoint inhibitor-related Sjogrens is different! More men, older patients, seronegative. Dry mouth >>dry eyes. Abstr#1905 #ACR19 @RheumNow @LCalabreseDO #cleclinicrheum
Cassandra Calabrese CCalabreseDO ( View Tweet)
PREVENT trial of Secukinumabnr-axSpA. SEC 150 mg loading and no loading dose provided significant improvement in signs and symptoms of nr-axSpA through Wk 16. The safety profile of SEC was consistent with the established safety profile across indications #L2 #ACR19 @RheumNow
Dr. Antoni Chan synovialjoints ( View Tweet)
The cytokine storm syndromes including MAS, HLH, autoinflammatory disease. Cron R #ACR19 #acrbest @RheumNow https://t.co/oy2QPHk8jh
Dr. Antoni Chan synovialjoints ( View Tweet)
Immune-mediated causes of uveitis
• Behcet’s disease
• Cogan’s syndrome
• IBD
• TINU
• JIA
• Multiple sclerosis
• Psoriatic arthritis/ AS/ Reactive Arthritis
• Relapsing polychondritis
• Sarcoidosis
• SLE
• Vasculitis
• Vogt-Koyanagi-Harada Syndrome
#ACR19 @RheumNow
Kanika Monga, MD DrKanikaMonga ( View Tweet)
MTX v. Mycophenolate – FAST uveitis trial
– 265 adults with non-infectious uveitis
– Oral MTX 25 mg v. MMF 3 grams daily
– MTX non-inferior to mycophenolate
Ophthalmology, 2018. 125(2):193.
JAMA, 2019. 322(10):936.
#ACR19 @RheumNow
Kanika Monga, MD DrKanikaMonga ( View Tweet)
Abstract #0626
Are there really differences between non-radiographic and radiographic axial spondyloarthritis? Data from the Spanish Atlas
#ACR19 @RheumNow https://t.co/hg3U2QjpFp
Kanika Monga, MD DrKanikaMonga ( View Tweet)
More than half of rheums who tweet and answer polls at #acr19 don’t look at synovial fluid anymore (maybe even more don’t in the real world) due to time constraints— your thoughts? @Rheumnow https://t.co/78d6MwbsXB
k dao KDAO2011 ( View Tweet)
Poor prognostic factors for MDA-5 ILD:
- Ferritin > 1000 ng/mL prior Rx
- GCO or consolidations in all lung fields
- Worsening of lung consolidations during Rx
#ACR19 @RheumNow
Kanika Monga, MD DrKanikaMonga ( View Tweet)
Myositis -- Ask for muscle biopsy when:
- high clinical suspicion w/ negative myositis specific antibodies
- high clinical suspicion of inherited muscle disease
- isolated elevated CPK
- recalcitrant to treatment
- atypical presentation
#ACR19 @RheumNow
Kanika Monga, MD DrKanikaMonga ( View Tweet)
Sjogrens RCT of Tocilizumab showed no benefit. Wonder re outcomes and pt selection. Maybe pick early pts with high inflammatory markers or other organ involvement #ACR @RheumNow #Sjogrens abstr1904
Janet Pope Janetbirdope ( View Tweet)
Tofacitinib works in Polyarticular JIA. Maybe new hope for kids with JIA and benefits of oral medication #ACR #ACR19 #JIA @RheumNow L23.
Janet Pope Janetbirdope ( View Tweet)
Myositis-specific autoantibodies (MSA): an important tool to support the diagnosis of myositis
#ACR19 @RheumNow https://t.co/vgW2wxkemr
Kanika Monga, MD DrKanikaMonga ( View Tweet)
Certrolizumab pegol decreases uveitis in open label study of SpA with past uveitis and HLAB27 group enriched for recurrence. Pre and post Rx rates of uveitis were compared. 80% reduction of uveitis but uncontrolled and unblinded. #ACR #ACR19 @RheumNow
Janet Pope Janetbirdope ( View Tweet)