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EHR study of UK Clinical Practice Research Datalink studied 318 hospitalized gout pts showing there is a 30d increased risk of VTE after gout flare aIRR 2.31 (1.39-3.82), that disappeared 31-90d after. https://t.co/h2v8KbiSwX https://t.co/gsfnR50gTD

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Dr. John Cush RheumNow ( View Tweet)
Feb 21, 2023
Tigulixostat is a non-purine xanthine oxidase inhibitor studied in 143 gout pts vs PBO with goal of SUA < 5. TIG was effective at 50mg (47%), 100 mg (45% ), 200 mg (62%) vs PBO 2.6% at week 12; w/ more gout flares in PBO Rx pts (13% vs 9%) https://t.co/d9lAjCBUmZ https://t.co/BERW51HW2B

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Dr. John Cush RheumNow ( View Tweet)
Feb 21, 2023
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Half the Experts are Wrong (2.17.2023)

d Jack Cush, MD
Feb 17, 2023

Dr. Jack Cush reviews the news and tries to stump the expert panel this week on the podcast.

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Retrospective study of 64 gout pts having orthopedic surgery - perioperative flares more likely with Incr SUA, DM, tophi and diuretics. In 12 mos following surgery, recurrent gout more if ^SUA (45% vs 11%) & those w/ topic ((RR = 4.8; P = 0.029) https://t.co/iMDSWnb5Dv https://t.co/ZwUKBkZbSL

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Dr. John Cush RheumNow ( View Tweet)
Feb 15, 2023
New Guideline: Vaccinations OK With Few Tweaks for Rheum Patients Nearly all available vaccines can be given to people with rheumatologic diseases, according to a new, detailed guideline from the ACR. https://t.co/514mIylgzj https://t.co/9Zq9pGcujV

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Dr. John Cush RheumNow ( View Tweet)
Feb 07, 2023
Feb 3rd, today is #NationalWomenPhysiciansDay. The date honors Dr. Elizabeth Blackwell, 1st woman to receive an MD United States (1849). RheumNow will devote the whole month of April 2023 to our Campaign on Women in Rheumatology - stay tuned! https://t.co/l1M56L8h9N https://t.co/eQpetW02CE

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Dr. John Cush RheumNow ( View Tweet)
Feb 03, 2023
Rheumpix

Coffee with milk may have an anti-inflammatory effect

d EurekAlert!
Jan 30, 2023

Can something as simple as a cup of coffee with milk have an anti-inflammatory effect in humans? Apparently so, according to a new study from the University of Copenhagen. A combination of proteins and antioxidants doubles the anti-inflammatory properties.

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Rheumatic Disease - IBD Overlap Nearly one in 10 patients with IBD also have rheumatologic disorders, meaning that specialists have to talk to each other to develop a treatment plan that works for both conditions, a researcher suggested. https://t.co/s3u9q8Sw9Y https://t.co/RjFyEcm6FA

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Dr. John Cush RheumNow ( View Tweet)
Jan 30, 2023
Have a Rheumatology question or case for Jack Cush? Record it here and we may feature it on an upcoming podcast. Tell us your name and where you practice rheumatology. https://t.co/RaFKTqhQjN https://t.co/hH0NcpOoyx

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Dr. John Cush RheumNow ( View Tweet)
Jan 25, 2023
Burden of BMI on Costs of Musculoskeletal Diseases A cross-sectional global study shows a substantial impact of obesity and BMI on the health and economic impact of patients with musculoskeletal (MSK) disorders. https://t.co/EZJTnLeaOZ https://t.co/sAOQ3fuq8Z

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Dr. John Cush RheumNow ( View Tweet)
Jan 25, 2023
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Burden of BMI on Costs of Musculoskeletal Diseases

d Jack Cush, MD
Jan 23, 2023

A cross-sectional global study shows a substantial impact of obesity and BMI on the health and economic impact of patients with musculoskeletal (MSK) disorders.

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PsA Til Death Do Us Part (1.20.2023)

d Jack Cush, MD
Jan 20, 2023

Dr. Jack Cush reviews the highlights from the past week on RheumNow.com.

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Elevated Uric Acid Is Associated With New‐Onset Atrial Fibrillation

d Jack Cush, MD
Jan 16, 2023

A Longitudinal Swedish study has shown that elevated serum uric acid (SUA) levels has cardiovascular implications and may predict the development of atrial fibrillation (AFib). 

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AR882, selective uric acid transporter 1 (URAT1) inhibitor in development, completed a phase 2, 140 pt 12-week PBO controlled trial, where 75 mg/d lowered SUA by 59% (8.6 to 3.5 ) & 42% (8.6 to 5.0 ) in 50 mg dose group - all better than PBO https://t.co/HHzHWj4XQr https://t.co/gJD9hnkFJc

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Dr. John Cush RheumNow ( View Tweet)
Jan 16, 2023
UK Database 1,955 breakthrough COVID-19 infxs in 54,576 #gout pts compared to 52,468 w/o gout saw more in gout (adj HR 1.24), also w/ more #COVID hospitalizations (adj HR 1.30) & death (1.36), more so in women. Same for unvaccinated https://t.co/596KvupZxi https://t.co/BJJguQBdin

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Dr. John Cush RheumNow ( View Tweet)
Jan 10, 2023
The Daily Mail in the UK features a long review of Hx of #Gout (Disease of Kings) & being on the rise in the UK - features a video interview with Professor Philip Conahan (one of our speakers at RheumNow Live 2023!) https://t.co/dNC71DwXTf https://t.co/ZtmQgx5aHc https://t.co/2D3HE0GFO5

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Dr. John Cush RheumNow ( View Tweet)
Jan 05, 2023
The Daily Mail in the UK features a long review of Hx of #Gout (Disease of Kings) & being on the rise in the UK - features a video interview with Professor Philip Conahan (one of our speakers at RheumNow Live 2023!) https://t.co/dNC71DwXTf https://t.co/ZtmQgx5aHc https://t.co/2D3HE0GFO5

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Dr. John Cush RheumNow ( View Tweet)
Jan 05, 2023
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Lubricin as a Treatment Target in Gout?

d EurekAlert!
Jan 04, 2023

Many Americans think of gout as a disease from a bygone era, akin to rickets or scurvy. The condition commonly afflicted the rich and royal, including American historical figures such as Benjamin Franklin and Thomas Jefferson.

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Best of 2022: Allopurinol Safety in CKD Patients

d Jack Cush, MD
Dec 30, 2022

A study in the Annals of Internal Medicine reports chronic kidney disease (CKD) patients can be safely treated with allopurinol without an increased risk of mortality.

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Cool NEJM Case of Spinal Gout in 82-yr-old woman with 3-wk hx of severe LBP, rigors, anorexia, incomplete urination. Hx of PsA, CKD, CHF treated w/ Humira, HCQ, diuretics. Imaging tophi in spine, responded to steroids and allopurinol. https://t.co/Ny50BLk7H3 https://t.co/OOqjpmc1DA

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Dr. John Cush RheumNow ( View Tweet)
Dec 27, 2022

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