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Best of 2024: Lung Cancer in Rheumatoid Arthritis and Interstitial Lung Disease

d Jack Cush, MD

A matched cohort study from the Veterans Health Administration shows that rheumatoid arthritis patients have a >50% increased risk of lung cancer, and a 3-fold higher risk of lung cancer in RA-interstitial lung disease (ILD).

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Best of 2024: Analgesic Prescribing in Patients with Inflammatory Arthritis

d Jack Cush, MD

A UK cross-sectional EHR clinical practice analysis between 2004 and 2020 shows that analgesic prescribing in inflammatory arthritis patients has declined, but still remains substantial, including opioid prescribing. Data was drawn from the Clinical Practice Research Datalink Aurum to evaluate analgesic prescription annual prevalence in patients with RA, PsA and axSpA and found that analgesic prescribing declined over time but remained common.

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Bah Humbug Vitamin D (12.20.2024)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com.

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Best of 2024: Prescription Painkiller Misuse in Chronic Pain Patients https://t.co/AyccRCuAHh https://t.co/RYuvDwHANo

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Best of 2024: Diagnosing Seronegative Sjogren's Disease

d Jack Cush, MD

Sjögren disease (SjD) is highly prevalent, but diagnosis may be challenged if anti-SSA antibodies or a labial salivary gland biopsy are negative. A recent cohort analysis suggests a novel autoantibody profile has predictive value SSA negative SjD and also in those with a positive labial biopsy.

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Natl Center for health statistics 11/24 report shows in 2023, 24% of adults had chronic pain (8.5% that limited life/work=high-impact chronic pain). Chronic pain and high-impact chronic pain both increased with age & decreasing urbanization. https://t.co/tMmgHVWnCf https://t.co/O3P4Vrmkei

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Dr. John Cush RheumNow ( View Tweet)
Nailfold video-capillaroscopy (NVC) study of 76 dermatomyositis (DM) pts - 74% had anomalous NVC patterns (diminished density, abnl morphology). NVC abnl pts had more Raynaud's, and cluster 1 were more likely to develop ILD.https://t.co/OC7jNHdFMn https://t.co/cCCO70Xzoh

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Dr. John Cush RheumNow ( View Tweet)
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Best of 2024: Determinants of Gout Flares

d Jack Cush, MD

Approximately 12 million US adults in the US have gout. Two recent literature reports in JAMA and Arthritis Care & Research highlight contributors to gout flares.

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ICYMI: Sex related differences in PsA Different factors are known to influence disease characteristics and outcomes in psoriatic arthritis (PsA). Recently, there is new evidence that sex-related differences play a role not only in disease manifestations but also in efficacy and… https://t.co/60vdbWLltB https://t.co/nY1CuJhKMb
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ICYMI: Beyond the Needle: Redefining the Assessment of Lupus Nephritis Lupus nephritis is one of the most silent and severe manifestations of systemic lupus erythematosus (SLE). When not captured early, patients are at high risk of progressing to end-stage renal disease, which… https://t.co/ctngE0bMkX https://t.co/koDBZaPc19
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Rheumatoid Arthritis Boosts Risk for Some Types of Heart Failure Rates of heart failure with preserved ejection fraction (HFpEF) were doubled in patients with rheumatoid arthritis (RA) relative to other people of the same age and sex, researchers found.… https://t.co/t7GRp7c63x https://t.co/Ov6UwGlPko
Dr. John Cush RheumNow ( View Tweet)
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Tocilizumab Efficacy in Giant Cell Arteritis Phenotypes

d Jack Cush, MD

A Spanish Collaborative Group study of Tocilizumab (TCZ) in Giant Cell Arteritis (GCA) demonstrated high efficacy regardless of the different vascular phenotypes treated. 

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Biosimilars Do Impact Biologic Drug Costs

d MedPage Today

Introduction of biosimilars for the rheumatology drug adalimumab, whose original branded version Humira has long been a blockbuster, appears to have led to a dramatic drop in net spending for these products -- even though biosimilars barely dented Humira prescription rates.

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ICYMI: Sex related differences in PsA

d Adela Castro, MD

Different factors are known to influence disease characteristics and outcomes in psoriatic arthritis (PsA).

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Japanese registry study of CV & CA outcomes in #RA. CV (MACE) events = IR 0.49/100 PY. Cancer= IR 0.78/100PY. MACE risk factors: Male, age≥65, HTN, Renal or cerebrovascular Dz; CA risk w/ Male, age, NSAID, COPD, SIE, CA Hx. https://t.co/uBFbho25La https://t.co/3ClEwCvdDY

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Dr. John Cush RheumNow ( View Tweet)
International Map of Axial SpA study surveyed 5557 axSpA pts (3231 Europe, 770 USA); mean 44 yrs old; 55% females. mean BASDAI was 5.4 (75% had active disease -BASDAI ≥4). Active Dz highest in S. Africa 87%, vs 68% in Asia. Active Dz assoc w/ active functional limitation,… https://t.co/j8CjuLHHjD https://t.co/tV9S3b7YCM
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Although there is a bidirectional relationship betw pain and sleep, Sleep impairment more strongly predicts pain than pain does sleep. Addressing sleep disturbances is crucial, as it is linked to higher levels of disability, depression, pain-related catastrophizing.… https://t.co/pcFeCWSBCg https://t.co/0QlnbpKEbp
Dr. John Cush RheumNow ( View Tweet)
CorEvitas registry study of 1823 psoriatic arthritis pts found that 11.1% fulfilled the fibromyalgia definition and 20.6% fulfilled the widespread pain definition. Factors assoc w/ FM: female, depression, anxiety, impaired function, BMI & #of comorbidities.… https://t.co/nDk8hPTlAu https://t.co/jnO5MijoGJ
Dr. John Cush RheumNow ( View Tweet)
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54K Peptic Ulcers Annually (12.13.2024)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com

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Predicting Flares in Rheumatoid Arthritis Dr. Jonathan Kay interviews Dr. John Isaacs about abstract 1349, presented at the 2024 ACR Convergence meeting in Washington, DC. https://t.co/pM1AgPiRla https://t.co/0hP5y1JgPq

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