Update on ACR Guideline on Prevention and Treatment of GIOP. Sequential Rx when initial OP Rx and GC discontinued https://t.co/TWdI728pCp Mary Beth Humphrey #ACR22 @RheumNow https://t.co/i320si4RJp

• http://bit.ly/3hFVMzc

Sarilumab (IL-6R inhibitor) in phase 3 trial for relapsing PMR (SAPHYR trial). Key inclusion: Disease flare while taking >7.5mg prednisolone Sustained remission: resolution of symptoms, normalisation of CRP, adherence to prednisolone taper @RheumNow #ACR22 #Plenary

Spiera et al. Sarilumab in refractory PMR (SAPHYR) - Phase 3 RCT. Significant effect of IL-6i. @RheumNow #ACR22 Abstr#1676 https://t.co/2MS441B8gU https://t.co/jBd7YJKrTs

• Sarilumab in Patients with Relapsing Polymyalgia Rheumatica: A Phase 3, Multice…

#ACR highlights - #pegloticase in #gout - less reactions and more benefit w #MTX MIRROR RCT. Better than no MTX. Will change my practice - if I can access to a #peguricase, I will Rx w concomitant MTX Abst#0001 #ACR22 @RheumNow

Updated ACR Guidelines on Prevention and Rx of GIOP Rx recommendations when new fractures occur after 12 months of initial OP Rx https://t.co/TWdI728pCp Mary Beth Humphrey #ACR22 @RheumNow https://t.co/wHANvymd5R

• http://bit.ly/3hFVMzc

Updated ACR Guidelines on Prevention and Rx of GIOP OP Rx in special populations https://t.co/TWdI728XrX Mary Beth Humphrey #ACR22 @RheumNow https://t.co/0h72a4jXmG

• http://bit.ly/3hFVMzc

PATCH study, 👁 safety data in children 5 yrs after birth In utero HCQ exposure does NOT: -impact retinal morphology (OCT) -reduce significantly retinal thickness https://t.co/D7SgPG6PX4 Abs#1647 #ACR22 @RheumNow

• In Utero Exposure to Hydroxychloroquine Does Not Associate with Ocular Toxicity…

WE-CAN pragmatic RCT on community-dwelling ♂️&♀️ >/=50y w/ knee #osteoarthritis & obesity: 💠Diet + exercise = significant weight ⬇️and ☑️WOMAC pain score, WOMAC function, 6min walk distance & SF-36 HRQoL 🍽️+🚶‍♀️in OA? = Yes we can! #ACR22 @RheumNow @rheumarhyme https://t.co/Ty2boH52HC

Ab1675 #ACR22 WE-CAN - Knee OA 823 randomized pts, 18 mo: Intensive Diet & Exercise (D+E) Primary endpt: WOMAC pain - 32% reduct in pain in D+E, vs 24% (PBO) 20% more likely: clinically meaningful improve Improved BMI, 6MW, HRQoL, activity Pain Rx, depression: no change @RheumNow https://t.co/Su2g4Z38FV

Does diet & exercise work for knee pain in #osteoarthritis? Pragmatic trial in 3 community sites. 823 RCT, 80% completed -control was education &meetings vs diet&exercise;more intense. 101kg, 77% F, age 65. Diff modest-favoured diet & exercise-works a bit #ACR22 @RheumNow #1675 https://t.co/akjEjVprJl

Pain in #psoriaticarthritis might not be all inflammatory.. In this study presented by Dr F Sunzini: 👉PsA pts w/⬆️FM scores had⬆️functional brain connectivity bet mid-post IC & thalamus, phgyrus & PFC ..so consider nociplastic pain too & adjust mgt #ACR22 @RheumNow ABST#2256 https://t.co/suCAvx0pD5

Plenary session III: Intensive diet and exercise program in overweight/obese pts with knee OA showed significant reduction in weight, pain and function, greater walk distance and quality of life. Abs#1675 @RheumNow #ACR22 https://t.co/vstfJahLQV

Bruce et al. Rheumatic disease onset/flare with ICI assoc good tumour response in melanoma. OR = 14.151 @RheumNow #ACR22 Abstr#1668 https://t.co/870ODwva5n https://t.co/bcneKZbeC4

• Rheumatic Toxicities of Immune Checkpoint Inhibitors Predict Favourable Tumour …

Bass et al. Treatment ICI-arthritis. Tricky one. MTX alone assoc longer time to cancer progression and to arthritis control compared to combination with bDMARD. Thoughts @drdavidliew ? @RheumNow #ACR22 Abstr#1669 https://t.co/8KH8RZzcaZ https://t.co/DtpA8s4PLy

• Comparing the Safety and Effectiveness of Methotrexate, TNF and IL6 Inhibitors …

Are your SpA pts planning on conceiving? Be careful with NSAID use French study found age and NSAID use associated with longer time-to-conception. Factors not associated: smoking, BASDAI score, DMARD use #ACRBest Abs#1673 @RheumNow #ACR22 https://t.co/D63XTY7IB8