Methotrexate plus leflunomide combination therapy for PsA treatment resulted in greater improvement in disease activity when compared to MTX monotherapy. As expected, MTX+LEF less well tolerated. @RheumNow #EULAR2022 ABST#0078 https://t.co/Bo64QX3Bf9

Women with spondyloarthritis at increased risk of gestational diabetes, elective and emergency C-sections, and spontaneous pre-term birth. Infants were not more likely to be born SGA. @RheumNow #EULAR2022 ABST#OP0126 https://t.co/BTXQqruvPs

Study of 2.9k offspring exposed to adalimumab, infliximab, golimumab during pregnancy, as compared to etanercept and certolizumab showed an adjusted hazard ratio for serious infections of 1.20 (CI 0.54, 2.64). @RheumNow #EULAR2022 ABST#OP0130

#OP0146 #EULAR2022 Is Anti-Ro(52) ab+ on isolation clinically significant? A study of 300 #Sjogren patients showed milder tissue inflammation but a higher risk for fibrosis (lungs) in this group. Interesting to see transcriptomic analysis to identify appropriate target @RheumNow https://t.co/vdxedCI2pk

Are TYK2 inhibitors ‘ticked’ to be part of the JAK family? Are Tyk2 inhibitors JAK inhibitors? Yes, no, maybe Check out all of Dr. Janet Pope’s TYK2 Q&A. https://t.co/IqeGqt6M4t https://t.co/kjWLVKVFP7

• https://bit.ly/3m4xiOT

Differentiating AS from OCI using CT scanning by Terrier et al showed that Subchondral Bone Attenuation Coefficient (SBAC) was higher in OCI than AS with a threshold of >7500 Hounslow Units discriminating the two conditions #EULAR2022 @RheumNow POS0126 https://t.co/8MdSe3Dqp7

Measuring liver stiffness (LS) by transient elastography can detect and follow up hepatic involvement in AL amyloidosis as radiolabelled SAP scan not widely available by Brunger et al . Higher LS in with liver involvement vs heart/no involvement #EULAR2022 @RheumNow POS0124

GM-CSF increased in patients with active ankylosing spondylitis, correlates with disease activity, not duration. TNFi does not affect GM-CSF levels. Could explain efficacy of JAKinibs and response for residual inflammation during TNF blockade. @RheumNow #EULAR2022 ABST#OP0107

Depression was the most prevalent comorbidity (31%), hypertension (26%) and uveitis the most common EMM (30%) in AS from the PSOAS cohort by @rheum_cat . Five clusters identified with depression and hypertension groups having higher disease activity #EULAR2022 @RheumNow OP0154 https://t.co/dpqaFD4Qzw

Check out my thoughts on this work on PMR's immunol signature: video: https://t.co/7aTJMsR9Te article: https://t.co/PTDHPv7gZC for @RheumNow's #EULAR2022 coverage PS just had a quick chat with @jiemy_william, so much exciting stuff to come from @VasculitisUMCG @ElisabethBrouw3! https://t.co/l94F5qAgDI

• Getting Real on PMR | RheumNow
• Polymyalgia rheumatica immunological puzzle further illustrated | RheumNow
• David Liew on Twitter: "PMR bursas are filled with macrophage subtypes esp…

#POS0716 #EULAR2022 Systematic review and meta-analysis of 7 studies (i.e. only 1 x proof of concept RCT) showed high SRI-4 response rate (82%) in #lupus patients treated on IL2. Injection reaction (33%) and Fever (24%). Promising and definitive RCT is needed @RheumNow https://t.co/BBcgt11yNT