Dr. John Cush RheumNow
4 years 5 months ago
Adipokines are associated with CHF hospitalization (HR 1.39) & CVD-related death (HR 1.49) in #RA pts, especially in non-obese RA. This includes High leptin assoc w/ CV-death (HR 1.44) and High FGF-21 w/ lower CAD (HR 0.75) https://t.co/GQx1kzFOIJ https://t.co/M6MF73xPYs
Today, the U.S. Food and Drug Administration authorized a second booster dose of either the Pfizer-BioNTech or the Moderna COVID-19 vaccines for older people and certain immunocompromised individuals. The FDA previously authorized a single booster dose for certain immunocompromised individuals following completion of a three-dose primary vaccination series.
Dr. John Cush RheumNow
4 years 5 months ago
Mark your calendars! RheumNow is covering PsA this April. That means more Therapeutic Updates, Tuesday Night Rheumatology, Expert Blogs, and more. Join us April 1-30. https://t.co/b6OgsR8uxL
Dr. John Cush RheumNow
4 years 5 months ago
A case–control study from Kaiser, compared obstetric complications in women who later developed Systemic Sclerosis (n=17) vs non-SSc controls (170). Obstetric complications higher in later SSc (71 v 50%) (HTN, PROM, IUGR, NICU, preterm births) https://t.co/4Y4eGuCFJi https://t.co/R4vw90bba4
Administrative claims analysis of biologic use in psoriasis (PsO) and psoriatic arthritis (PsA) in French health insurance databases shows that despite widespread biologic use, overall drug persistence (beyond 3 years) was low for PsO and PsA biologics.
The NEJM has published the results of the BRAVE-AA1 and BRAVE-AA2 trials, demonstrating that baricitinib is effective at regrowing hair in alopecia areata (AA) patients, thus paving the way for future regulatory approval for this difficult to treat disorder.
Alopecia areata is an difficult to manage autoimmune condition and in the US has a lifetime prevalence of roughly 2%.
Dr. John Cush RheumNow
4 years 5 months ago
Infection in lupus is suggested by very high CRP, PMN-lymph ratio (NLR) Plt-lymph ratio(PLR). Study of 104 hospitalized SLE found all very high w/ infx & Combined cutoffs of CRP >20 mg/L, NLR >3.5, PLR >151 had 87 sensitivity & 81% specificity for infx https://t.co/5SjFsrBiZp https://t.co/0Ipussd9fF
Dr. John Cush RheumNow
4 years 5 months ago
ICYMI: Montreal General Hosp SLE cohort study of 489 SLE pts - 35% have Raynauds phenomena; RP in SLE assoc. w/ Female (OR 2.43), White (OR 1.85), CNS disease (OR 1.98), RNP Abs (OR 3.0); negatively assoc w/ hemolytic anemia & cellular casts https://t.co/5t3GL4jqrm https://t.co/gVVqccvtca
Dr. John Cush RheumNow
4 years 5 months ago
ICYMI: Environmental Pollutants Ups Autoimmune Disease Risk
An Italian environmental study shows that air pollution increases the risk of autoimmune diseases, in particular rheumatoid arthritis, CTDs and inflammatory bowel diseases (IBD).
https://t.co/oKdgSZ2jAF https://t.co/WI7aShKR97
Dr. John Cush RheumNow
4 years 5 months ago
New podcast available on Lupus worries. Download wherever you get your podcasts.
https://t.co/gU1mmRXYUi https://t.co/54IDshqNYd
Dr. John Cush RheumNow
4 years 6 months ago
ICYMI: Effect of Intraarticular Steroid Shots on Knee OA Outcomes
In patients w/ OA of the knee, intra-articular injections of steroids didn’t increase rates of either disease progression or subsequent knee replacement surgery, researchers said.
https://t.co/qinnfFLsGQ https://t.co/6859pSNNhL
Dr. John Cush RheumNow
4 years 6 months ago
ICYMI: Drugs for Pregnancy Hopefuls
A Young Woman has uncontrolled RA, but wants to get pregnant.
What do you chose?
https://t.co/Sunx8RWRfM https://t.co/hsFNhVfwHd
Dr. John Cush RheumNow
4 years 6 months ago
ICYMI: Adalimumab Addition vs. Methotrexate Escalation in Psoriatic Arthritis
https://t.co/q0uIjLrT3G https://t.co/ehgEUSrbPg

