Dr. John Cush RheumNow
5 years 1 month ago
85 rheumatic kids RTX treated - New hypogammaglobulinemia in 27% w/in 18 mos AND 26% w/ infections (half being serious infx). Prior pulse steriods ups risk of inx (OR 15.3) and hypogamma (OR 3.9). Hypogamm predicts risk of SIE (OR 7.9)
Dr. John Cush RheumNow
5 years 1 month ago
In 206 #SLE pts (mean 62 yrs) polypharmacy (≥10 meds) seen in 35%. 31% used benzodiazepines & 24% opioids. Polypharmacy greater with prednisone, comorbidity & rural. Polypharmacy assoc w/ 4X Benzo & 7X opioid use https://t.co/4U0UakoIRr
Dr. John Cush RheumNow
5 years 1 month ago
Takayasu's responds to Tofacitinib - 53 pts given TOF + glucocorticoids (GCs) (n=27) or MTX + GCs (n=26). At 12 mos complete remission (CR) more with TOF (88% vs 56%, p=0.02), w/ lower GC use and relapse rates ((12% vs 35%, p=0.052) https://t.co/qgziyIhKgV
Eric Topol EricTopol
5 years 1 month ago
Current Israel data for mRNA vaccination in people age >60, 1st to get vaccines >6 months ago, now confronting Delta infections
1. Vaccines work but their apparent effectiveness is diminished over time + Delta
2. Boosters showing some preliminary evidence of working
via @dvir_a https://t.co/YKgF9dlFz3
Ashish K. Jha, MD, MPH ashishkjha
5 years 1 month ago
Today, the 5 most vaccinated states (14M people) had
580 people in hospital, 12 deaths
In the 5 least vaccinated states (16M people)?
6,600 hospitalized, 104 deaths
Per capita , least vaccinated states have
10X hospitalizations and 7X deaths
So yeah, vaccines are working
Mike Putman EBRheum
5 years 1 month ago
Nice rvw of tx for SSc-ILD by @sclerodermaUM et al
Endorse: "MMF is now considered the standard of care as first line
therapy for the treatment of SSc-ILD"
Reasonable chart, but wish we could offer more HSCT
Also, I'm seeing a LOT of INappropriate early use of nintedanib https://t.co/n1R73EbrXZ
In Canada, biologic DMARDs (bDMARDs) were introduced after 2001, and since that time there have been significant reductions in hip and knee arthroplasty (THA/TKA) among patients with rheumatoid arthritis (RA), but not in patients with osteoarthritis (OA).
The CDC had reported the Advisory Committee on Immunization Practices (ACIP) study of rare serious adverse events after COVID-19 vaccination and assert that the excessive morbidity and mortality from COVID-19 (and the protection afforded by vaccination) far exceeds the risk of rare safety signals reported following vaccination.
Dr. John Cush RheumNow
5 years 1 month ago
Smart, concise, insightful short video by Dr Marwan Bukhari (Editor-in-Chief of Rheumatology) on how to write an abstract. https://t.co/M8AUFZsxMF
Dr. John Cush RheumNow
5 years 1 month ago
The TORTUGA trial tested filgotinib, a JAK1 inhibitor, in active ankylosing spondylitis (AS) patients and was shown to be both effective and capable of retarding sacroiliac (SI) joint erosions as early as 12 weeks.
https://t.co/awfZdiTUBt https://t.co/ST2JIkavhy
Dr. John Cush RheumNow
5 years 1 month ago
TB rarely causes arthritis; accounts for 1-5% of all TB (10-30% of pulmonary TB) cases. May present as mono/oligoarthritis, tenosynovitis, dactylitis, Spondylitis (Potts disease), reactive arthritis (Poncets dz) or polyarthritis. https://t.co/RpMrRLQbEa
Dr. John Cush RheumNow
5 years 1 month ago
Safety and Tolerability of Subcutaneous Methotrexate
A large, single-rheum center analysis of oral and SC MTX use in daily clinical practice suggests that SC MTX has fewer drug discontinuations and is better tolerated compared to other DMARD therapies.
https://t.co/TZwZO9j5xd https://t.co/tx9dWoHUj0
Dr. John Cush RheumNow
5 years 1 month ago
It was a banner week at the FDA; a new drug approval you should know about; a lot of information about pregnancy and safety; and an interesting case plus a question from one of our readers--this and more in this week's podcast. Let's dive in.
https://t.co/5K8ejJ4jj2 https://t.co/RDEM0BMZLC
Dr. John Cush RheumNow
5 years 1 month ago
Lumbar Spine Decompression Alone is Superior to Decompression with Fusion
https://t.co/EjLoVZaJf5 https://t.co/OJHJl3EWsv
A large cohort study of rheumatoid arthritis (RA) patients shows that regular tea consumption was associated with a lower risk of RA.
