Dr. John Cush RheumNow
5 years 2 months ago
FDA delays in the analysis of Pfizers/Xeljanz Oral Surveillance Safety study has put off potential approvals for other JAKs (Lillys Oluminant in Eczema & Abbvies Rinvoq for Eczema, Psoriatic arthritis, Ank Spondylitis). The wait continues.. https://t.co/3pRp2Vnuhw
Dr. John Cush RheumNow
5 years 2 months ago
ICYMI: 263 RA patients with ILD were treated w/ Abatacept (ABA mono, ABA+MTX or ABA+nonMTX) - all improved their DAS28, stabilized their FVC, DLCO, Chest CT; Only difference was that steroid sparing best when ABA used in combo. https://t.co/1dGufcsRpC
JAMA has published the findings of trial wherein the anti–interleukin-1β antibody canakinumab (CAN) failed to improve survival in patients hospitalized with severe COVID-19.
Other studies have suggested that the use of IL-1 inhibitors (anakinra) may improve COVID outcomes, especially in those with impending hyperinflammation.
Dr. John Cush RheumNow
5 years 2 months ago
National Inpatient study (2000-2014) shows increased risk of vertebral compression fractures (VCF) in Ankylosing spondylitis (2.7%), compared to RA 0.77% & gen population 0.35%. VCF Hosp increased over time in AS, but decr in RA pts https://t.co/ugV44XJf8a
Dr. John Cush RheumNow
5 years 2 months ago
152 Israeli pts w/ Breakthrough COVID infx >7d after 2nd Pfizer vax; all hospitalized, 38 w/ Poor outcome & 22% (34/152) died. All were older, most males, w/ comorbidities, 40% immunocompromised; high risk w/ RTX & low anti-spike IgG titers https://t.co/x1Uuyo7qim
Dr. John Cush RheumNow
5 years 2 months ago
Study of 33 RCTs, 4544 pts Rx w/ either IL-17 or TNF inhibitors finds lower risk of UVEITIS with anti-TNF mAb (vs PBO OR = 0.46; vs IL-17i OR = 0.34. IL-17 inhibitors are not protective against uveitis https://t.co/AIxgI2qhq9
Dr. John Cush RheumNow
5 years 2 months ago
Study of 647 RA pts wanting to get pregnant finds only 3.9% SSA+ & 1.1% SSB+ (higher in RF+ pts); ~1/2 had SSA titre of >240 units/mL - but No cases of neonatal lupus or heart block seen. In a French register, SSA related CHB was 1.5% https://t.co/FmZzPpmB7D
Dr. John Cush RheumNow
5 years 2 months ago
Can you refuse to see unvaccinated pts? NY Times letter reviews options for “vaccine hesitant” or “vaccine refusing”
1. Ask if vaccinated
2. Offer telehealth
3. Require masks & distancing
4. Minimize contact betw vax & no-vax pts
5. Address pt concerns
https://t.co/LEJLDMIDyF https://t.co/stoUpzzK02
Dr. John Cush RheumNow
5 years 2 months ago
Botanical extract, Chrysanthemum zawadskii var. latilobum (GCWB) studied in 112 w/ mild-mod. knee OA. Randomized, double-blind, placebo-controlled study finds GCQB signif better than placebo in WOMAC total & function scores https://t.co/xyKlrL2CG7
The ACR and the Vasculitis Foundation have published their evidence-based recommendations and expert guidance for the management of GCA and Takayasu arteritis. These recommendations address a variety of clinical questions and scenarios including diagnostic testing, imaging, treatments, and surgical interventions. Recommendations for GCA and TAK include support for the use of glucocorticoid-sparing immunosuppressive agents and the use of imaging
Dr. John Cush RheumNow
5 years 2 months ago
Sweets Syndrome (Acute Febrile Neutrophilic Dermatosis) in NEJM. A 46-year-old woman with erythematous painful raised lesions on her thumb, arms and other areas. https://t.co/Tggz1lLULR
Dr. John Cush RheumNow
5 years 2 months ago
Do Women or Men make the best doctors? https://t.co/HTtZd9GHRH+
Dr. John Cush RheumNow
5 years 2 months ago
Carpal Tunnel Syndrome has an annual incidence of 0.4%. Population based study shows more likely in women, 50-59 years, w/ obesity, gout, rheumatoid arthritis or a prior hx of wrist injury. https://t.co/X7U5yh0R3l
Dr. John Cush RheumNow
5 years 2 months ago
Impact of Nail Psoriasis on Psoriatic Arthritis
Mease and colleagues have shown that psoriatic arthritis (PsA) patients with nail involvement have worse disease and outcomes than those without nail psoriasis.
https://t.co/fOiso0EGAK https://t.co/6YREBE2mHg
Dr. John Cush RheumNow
5 years 2 months ago
Top Tweet Last Week:
Potential Birth Defects with Hydroxychloroquine
HCQ is one of the safest meds used in rheumatology, but there is new claims data suggesting a small increase in the risk of malformations associated with first-trimester HCQ use.
https://t.co/IHNKjHVXaU https://t.co/Oay2ayVr9m
