A single center analysis of systemic lupus erythematosus (SLE) patients found symptomatic osteonecrosis (ON) in nearly 10%.
Researchers analyzed data from 912 SLE patients admitted to the hospital (1981 to 2012). Of these 912 SLE patients, 97 had symptomatic ON with an overall prevalence of 10.6%.
Dr. John Cush RheumNow
5 years 2 months ago
Todays NEJM: Ruxolitinib effective in glucocorticoid-refractory Chronic Graft-versus-Host Dz. Phase 3, 329 pts; wk 24 responses better w/ RUX (50 vs 26%; P<0.001). Important? as there is phase 2 data showing JAK efficacy in scleroderma https://t.co/ygLevqfuMW
Dr. John Cush RheumNow
5 years 2 months ago
In 2016, 552,230 RA adults were hospitalized -1120 for influenza, 590 H zoster, & 785 for S. pneumoniae. These infections constituted 0.5% of RA hospitalizations at a cost of $124 million & 13,750 hosp stay days. https://t.co/7vtsWafGvv
Lancet Rheumatology has published a cohort analysis showing that a small but significant subset of children presenting with arthralgia or arthritis may have a pediatric malignancy.
Dr. John Cush RheumNow
5 years 2 months ago
2020 saw record numbers of drug overdose deaths (93,331) a big increase (29.4%) over 2019, according to CDC & Natl Center Health Statistics (NCHS). Overdose deaths 69,710 primarily fentanyl, Rx pain meds and cocaine https://t.co/K9GlWAeALS
Dr. John Cush RheumNow
5 years 2 months ago
Telehealth has declined but still much higher than pre-pandemic. CMS is proposing to extend Medicare coverage of certain telehealth services until the end of 2023. A -3.75% payment adjustment has been proposed & will be debated https://t.co/ETK74d9uGT
Dr. John Cush RheumNow
5 years 2 months ago
Metanalysis shows that Ustekinumab (effective in IBD) may also control skin and joint extra-intestinal manifestations. Despite no effect on spondylitis, UST was effective at PSO, PsA, pyoderma gangrenosum, E nodosum stomatitis and uveitis https://t.co/NPxJdYUM7I
Chung et al have published the 2021 treatment guielines for the management of antineutrophil cytoplasmic antibody–associated vasculitis, including granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis. These guidelines are put forth by the ACR and the Vasculitis Foundation as benchmark guidance to assist health care professionals in managing AAV.
Dr. John Cush RheumNow
5 years 2 months ago
Systematic review of muscle relaxants use in nonspecific low back pain shows uncertain, small, but not clinically important reductions in pain in the 1st 2weeks. Muscle relaxants are 3rd most common Rx for LBP (30 mill Rx in 2016)(49 trials >6505 pts) https://t.co/zN5rvBF1HO
Dr. John Cush RheumNow
5 years 2 months ago
Norwegian pre-pregnancy registry studied 274 axial SpA and 317 RA women. Longer time to pregnancy (TTP) seen in 21% (32% TTP >12 mos). Longer TTP associated with older age, nulliparity, and longer disease duration. https://t.co/kT7fqnhTkw https://t.co/8qC1N2K7vI
Dr. John Cush RheumNow
5 years 2 months ago
NHANES survey study shows adult psoriasis in the US was 3.0% (7.5 million adults). Psoriasis was most common in non-Hispanic White individuals, and the prevalence of psoriasis has not significantly changed since 2003 in the US. https://t.co/3yrlPu1GGi
Gradual withdrawal of glucocorticoids was successful among patients with systemic lupus erythematosus (SLE) after 2 years of clinically quiescent disease, without an increased likelihood of flares, Canadian researchers reported.
Dr. John Cush RheumNow
5 years 2 months ago
Rare Myocarditis Risk following COVID-19 Vaccine
https://t.co/Q9QGhTTKvC https://t.co/dTOR9sZ3iP
Hydroxychloroquine (HCQ) is one of the safest meds used in rheumatology, but there is new claims data suggesting a small increase in the risk of malformations associated with first-trimester HCQ use.
Dr. John Cush RheumNow
5 years 2 months ago
FDA & CDC joint statement: Those who are "fully vaccinated do not need a booster shot at this time".
People who are not vaccinated remain at risk. Virtually all COVID-19 hospitalizations and deaths are among those who are unvaccinated. https://t.co/miqEJE4wgC
