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The NEJM has published the results of the ACCT-2 Study,  a double-blind, randomized, placebo-controlled trial evaluating baricitinib, an inhibitor of Janus kinase 1 (JAK1) and JAK2, plus remdesivir in hospitalized adults with Covid-19. The primary outcome was the time to recovery. The key secondary outcome was clinical status at day 15.
While RA incurrs a 2 fold risk of CHF; the use of HCQ does not add to a CHF risk. Mayo nested case-control study, compa

Dr. John Cush RheumNow

5 years 7 months ago
While RA incurrs a 2 fold risk of CHF; the use of HCQ does not add to a CHF risk. Mayo nested case-control study, compared RA w/ CHF vs nonCHF RA pts, showing HCQ use, nor duration of use, failed to increase CHF (OR: 0.96).https://t.co/Tx9jr07C7i
QD Clinic - I'm Ready to Fly
Analysis of the NHANES population survey data shows weight gain during adulthood increases the risk of gout and that maintaining normal weight could reduce the overall gout risk by nearly 33%. Obesity and gout have long been linked, but the the influence of weight changes during adulthood has not been examined. 
QD Clinic - Don't Stop Believin'

Rheumatic Patients Should NOT Stop DMARDs if the get COVID-19

https://t.co/0JAqwbatn0

Dr. John Cush RheumNow

5 years 7 months ago
QD Clinic - Don't Stop Believin' Rheumatic Patients Should NOT Stop DMARDs if the get COVID-19 https://t.co/0JAqwbatn0 https://t.co/3dzU1HHm5e
GSKs RCT showed otilimab (investigational anti-GM-CSF Ab) in severe COVID-19, was not superior to SOC for the primary e

Dr. John Cush RheumNow

5 years 7 months ago
GSKs RCT showed otilimab (investigational anti-GM-CSF Ab) in severe COVID-19, was not superior to SOC for the primary endpoint - the proportion alive and free of respiratory failure at 28 days (but was effective in pts >70 yrs (65% vs 46%) https://t.co/OHvWGGlgKv
QD Clinic - Don't Stop Believin'
A systematic review of telehealth in delivering equivalent care in RA patients demonstrates there is limited evidence that virtual RA care is equivalent to conventional face-to-face care. Despite current widespread use, there is a great need for credible well-designed research that will address comparable patient outcomes, implementation strategies and long‐term health system consequences. 
620 RA patients from Nordic biologics registers started a non-TNFi as 1steverr bDMARD but later switched to a 2nd bDMARD

Dr. John Cush RheumNow

5 years 7 months ago
620 RA patients from Nordic biologics registers started a non-TNFi as 1steverr bDMARD but later switched to a 2nd bDMARD (ABA 86, RTX 40, TCZ 67 TNFi 427). Retention was 70% @ 6 mos & 50% @12 mos. 30-40% on 2nd bDMARD reached LDAS or remission https://t.co/u8BQn0rYca
Combo Therapy Boosts Response in Uncontrolled Gout
  • MedPage Today
The addition of an immunomodulating agent to pegloticase (Krystexxa) among patients with uncontrolled gout significantly improved response rates, a systematic literature review found.
Influenza vaccinations may hit a record high this season. Last year 48.4% of Americans got the flu shot. Survey suggests

Dr. John Cush RheumNow

5 years 7 months ago
Influenza vaccinations may hit a record high this season. Last year 48.4% of Americans got the flu shot. Survey suggests that nearly two-thirds will have flu vax this year (44% already had a flu shot, 13.5% said they will get& 9.3% said probably will get) https://t.co/3CnIdx49rW https://t.co/Khp6wsahCD
Report from DANBIO Danish register looked at chronic pain in a matched cohort study of Psoriasis. Chronic pain was not

Dr. John Cush RheumNow

5 years 7 months ago
Report from DANBIO Danish register looked at chronic pain in a matched cohort study of Psoriasis. Chronic pain was not associated with excess mortality (hence not PsA) (OR 0.99,0.95-1.03). Mortality was increased with steriods, COPD, DM, CA, CV disease.  https://t.co/91JW3BOPtw
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