Dr. John Cush RheumNow
6 years 2 months ago
Belimumab FDA approved in kids (same dose 10mg/kg/IV) based on PLUTO trial - 93 SLE pts Rx w/ BEL or PBO. By wk 52, BEL had more SRI4 responders (52.8% vs 43.6%; OR 1.49;95% CI 0.64 to 3.46), more PRINTO/ACR 30 or 50 w/ stable PK. https://t.co/1xX0VLgl4q
Dr. John Cush RheumNow
6 years 2 months ago
The RheumNow Podcast is up - COVID-19 Responds to Steroids & TCZ, statin myopathy, Lung Dz in AOSD, TNFi & Liver, IL-23 in Psoriasis. Watch it here>> https://t.co/DrrFZSWmZa or listen to Podcast on iTunes>> https://t.co/FHJv01AAbC or on SoundCloud>> https://t.co/nSPI9lcaY9
The American College of Rheumatology (ACR) has issued a guidance document for rheumatologists and rheumatology health professionals to consider as practices, business and patient care begins to reopen in this next phase of the COVID-19 pandemic. This document discusses local conditions, design reopening procedures, monitoring and patient advice for this transition.
Dr. Jack Cush reviews the News and Journal Reports from the past week on RheumNow.com.
Dr. John Cush RheumNow
6 years 2 months ago
Cross-sectional survey of 3200 PsA/Pso patients. 65% had both joint & skin involvement. Latter pts had worse QoL, work impairment, higher TJC (5.2) & SJC (4.8) (vs 2.0 & 1.5); more flares (35 vs. 23%, p < 0.001). Jts bigger burden (62%) vs skin (38%) https://t.co/mpmpF4LiLR
Dr. John Cush RheumNow
6 years 2 months ago
CORRONA Registry shows no difference in 1 year outcomes when RA patients are given 1st line TNF inhibitors compared to 1st line non-TNF biologics (ABA, TCZ, RTX, anakinra, TOFA: thus supporting current RA guidelines, recommending individualised care https://t.co/YWJicBMAAK
In an Annals of Rheumatic Disease report, Italian investigators performed consecutive testing for SARS-CoV-2 (IgM and IgG) between 25 March to 25 May 2020 and compared test results between rheumatic disease (RMD) patients and the general population.
Dr. John Cush RheumNow
6 years 2 months ago
Metanalysis of 7 RCTs looked at melanoma risk comparing 34 029 biologic Tx vs 135 370 non-biologic conventional systemic Tx pts, showing no signif. increased risk in IBD (RR 1.20; 0.60-2.40), RA (pRR 1.20; 0.83-1.74), or psoriasis (HR 1.57; 0.61-4.09) https://t.co/PCOddiwKv0
Jonathan Hausmann MD hausmannMD
6 years 2 months ago
Here's our experience at @BostonChildrens in managing patients with MIS-C, as well as how to distinguish these patients from those with #kawasakidisease --> https://t.co/C0nesg40FD
Just published in @jclinicalinvest #COVID19 https://t.co/U1u7uXtHnR
According to a small, observational study out of UCLA published as correspondence in the NEJM on July 21, 2020, those with mild COVID-19 symptoms showed an approximate antibody half-life of 73 days.
COVID-19 infection was confirmed by PCR in 30 out of 34 study participants. The remaining four patients developed consistent symptoms and cohabitated with a person who had a known positive test but could not get testing due to availability or mild
Dr. John Cush RheumNow
6 years 2 months ago
FDA has issued draft guidance on Cannibis research: “Cannabis & Cannabis-Derived Compounds: Quality Considerations for Clinical Research, Draft Guidance for Industry,” outlines FDA’s current thinking on clinical research related cannabis-derived compounds https://t.co/ppvisN1oxU
Dr. John Cush RheumNow
6 years 2 months ago
Aurinia Announces U.S. Food and Drug Administration Acceptance of the Filing of
New Drug Application and Priority Review for Voclosporin for the Treatment of Lupus
Nephritis https://t.co/BMgqvuAUP5
The number of reporting cases of COVID-19 infection tends to underestimate the true prevalence of infection as only the more severe cases (e.g.,acute respiratory syndrome) get tested or go to the hospital. JAMA Internal Medicine reports that a cross-sectional seroprevalence study from the U.S. shows that COVID-19 is underreported and that actual infection rates can be 6 to 24 times more prevalent than currently reported infections due to
Dr. John Cush RheumNow
6 years 2 months ago
Systematic review of 100 pts with statin-associated myopathy showed mean age 65 yrs, presenting w/ symmetric prox. muscle weakness, mean CK=6853 IU/l, all were HMG-CoA reductase Ab+ & >80% had necrotizing myopathy & required immunosuppressants https://t.co/BoNmOHPkGH

