Dr. John Cush RheumNow
6 years 3 months ago
66 critically ill & 13 non‐critically ill COVID‐19 were tested for multiple anti‐phospholipid (aPL)Abs. APL common (47%) in critically ill, may be transient (35‐39d post onset). Multiple medium/high levels aPLs may identify at risk for CVA or APS
Dr. John Cush RheumNow
6 years 3 months ago
Schulz-Koops reports 2 #RA patients Rx with RTX who died from COVID pneumonia and ARDS. Both were older, had comorbidities (COPD, HTN, OP) and had received last RTX either 2 wks and 6 mos before COVID infection onset; both had nl IgG levels https://t.co/j043Tggdbg
Dr. John Cush RheumNow
6 years 3 months ago
Nested case-control study of 5858 SLE patients - 51 developed cancer; most common were thyroid CA (27%), cervical (20%), & lung (14%). No risk imposed by steroids, CTX, MTX or azathioprine. But HCQ use was associated significantly lower Cancer risk in SLE https://t.co/3R0iakKbVG
Two recent reports further characterize the newly described, Kawasaki-like, syndrome affecting children with COVID-19 infections.
The NEJM describes the childhood syndrome as having Kawasaki’s disease, fever, toxic shock syndrome, acute abdominal conditions, and encephalopathy; hence the label Childhood Multisystem Inflammatory Syndrome. The disorder emerged in late April 2020, first in the U.K., and then similar cases
Dr. John Cush RheumNow
6 years 3 months ago
National Inpatient study of 61,615 systemic sclerosis pts (1998–2016) finds most common serious infections were pneumonia 45%, sepsis 32%, SSTI 19%; by 2015–2016, sepsis 1.8X more common than pneumonia. Hosp SIE mortality decr over time (10% to 8%) https://t.co/nv1KjaL3w4
Dr. John Cush RheumNow
6 years 3 months ago
According to the Agency for Healthcare Research & Quality, it is estimated that 40-80% of information a patient is told during an office visit is forgotten immediately, and that almost half of the information a patient does retain is actually incorrect https://t.co/XeGx2YXsOQ
Dr. John Cush RheumNow
6 years 3 months ago
2000–2016, analgesic use for OA has changed in UK. Oral NSAIDs Rx decreased & other analgesics/opioids increased (P < 0.001). Pts w/ GI dz likely to recv topical NSAIDs, tylenol, opioids. Opioids moreso in elderly, women, obesity, smokers, comorbidities. https://t.co/AJiWUAycLb
Dr. John Cush RheumNow
6 years 3 months ago
CHMP of the EMA has recommended approval of intravenous & subcutaneous formulations of CT-P13 (Remsima) for use in 5 conditions - Crohn, UC, ankylosing spondylitis, PsA & psoriasis. Remsima dose is 120 mg q 2wks regardless of body weight. https://t.co/eDUCvQost9
The American College of Rheumatology (ACR) has released an official position statement supporting the role of telemedicine as a tool with the potential to increase access and improve care for patients with rheumatic diseases. It also highlights the significant barriers and opportunities presented to patients and rheumatology professionals.
Dr Yeliz Prior #BlackLivesMatter YelizPrior
6 years 3 months ago
A must watch with volume on! It is so relatable. I might adopt the same response next time I get that question "But where are you from? shortly after I said Cheshire. Even though I wasn't born here, I think spending best half of my life here qualifies the answer. https://t.co/dVdgjQl7pU
ARD & RMD Open ARD_BMJ
6 years 3 months ago
Increased rate of hospital #COVID-19 cases associated with some but not all chronic #inflammatory or #autoimmune conditions compared with reference population.
The risks seem to depend on age, the specific disease and previous therapies.
https://t.co/8j6R0oO99y https://t.co/n3cEXFx9Kk
Eric Topol EricTopol
6 years 3 months ago
Now with ~1,000 children and adolescents with multi-inflammatory syndrome in children (MIS-C), it can be considered a new disease. Today new @NEJM reports and an editorial on its status. I've made a summary of some key points to start https://t.co/1HSWSvumpv
Data presented at the recent American Academy of Dermatology meeting suggests that interleukin (IL)-23 inhibition with risankizumab was more effective than the IL-17 inhibition (secukinumab) based on a 52 week randomized head-to-head trial in moderate to severe psoriasis patients.
Dr. John Cush RheumNow
6 years 3 months ago
The CHMP of the European Medicines Agency has recommended the label expansion of IL-17 inhibitor, Cosentyx (secukinumab) for the treatment of moderate-to-severe plaque psoriasis in children and adolescents aged 6-18 years. https://t.co/1qYL5ASkrg
A retrospective, observational study published in Lancet Rheumatology has shown that tocilizumab (TCZ) may reduce the risk of death or the need for mechanical ventilation in severe COVID-19 pneumonia. This observational study included adults, with severe COVID-19 pneumonia, who were hospitalized between Feb 21 and March 24, 2020. All were on the standard of care (ie, supplemental oxygen, hydroxychloroquine, azithromycin, antiretrovirals,

