QD Clinic - Kid Arthritis
Joint Pains in Kids? Think Hypermobility
Dr. John Cush RheumNow
6 years 7 months ago
Risk factors for severe cranial ischaemic complications (sCIC) in GCA studied in 295 pts - 61 developed sCIC. Vision complications increased with age & jaw claudication (OR 3.43); decreased with PMR Sxs & higher CRP. Afib independent predictor of stroke. https://t.co/8VoZoVGVIp
A full-read, novel Viewpoint article published in the Annals of Rheumatic Disease (Huizinga TWJ, et al) spotlights a recent international meeting of big thinkers, scientific collaborators and industry dedicated to innovation in rheumatology.
Science Translational Medicine features a report from the Fred Hutchinson Cancer Research Center showing that a scopion venom peptide, coupled to steroid, can significantly reduce joint inflammation in a rat model of rheumatoid arthritis (RA).
Dr. John Cush RheumNow
6 years 7 months ago
Study of 244 PsA &198 AS pts finds B27(+) in 25% PsA, 75% in AS. HLA‐B27 more likely to be younger, male, longer Dz duration, higher Xray scores. B27 was signif assoc w/ syndesmophyte symmetry, marginal syndesmophytes, but not sacroiliac symmetry. https://t.co/8MFVrTLWmF
Dr. John Cush RheumNow
6 years 7 months ago
ANA positivity very common with liver diseases - 91% in syst autoimmune dz, 93% in PBC, 49% Autoimmune hepatitis, 19% in HBV, 14% in HCV, 23.5% in Hepatocellular carcinoma; but few had ANA ≥ 1:320 (5 HCC, 2.5%HBV, 1.6% HCV). Patterns also varied. https://t.co/1wnr9sHjye
Dr. John Cush RheumNow
6 years 7 months ago
Apheresis not generally rec for SLE but .... Could be useful w alveolar hemorrhage, etc. Dr Compton #Utsw Rheum Grand Rounds https://t.co/fIBAMWVU4W
Dr. John Cush RheumNow
6 years 7 months ago
CAPS, best outcomes with triple therapy that includes Apheresis. Dr Compton #Utsw Rheum Grand Rounds https://t.co/MVesTmSNQK
Dr. John Cush RheumNow
6 years 7 months ago
Criteria for CAPS. Dr. Compton #Utsw Rheum Grand Rounds https://t.co/tdVWhMEII3
Dr. John Cush RheumNow
6 years 7 months ago
Indications for Apheresis Dr Compton #Utsw Rheum Grand Rounds @FrancesComptonx https://t.co/CLfSMgdQkL
Dr. John Cush RheumNow
6 years 7 months ago
With 5 plans exchanges you can reduce IgG by 85 % Dr Compton #Utsw Rheum Grand Rounds https://t.co/zsxn07Z8r6
Dr. John Cush RheumNow
6 years 7 months ago
Dr. Frances Compton #Utsw Rheum Grand Rounds on Therapeutic Apheresis - able to remove https://t.co/6V5i8bwXY3
Dr. John Cush RheumNow
6 years 7 months ago
NICE cost analysis of combination DMARDs vs Biologic/MTX in 205 RA pts shows combo DMARDS achieve similar clinical benefits more cheaply than high-cost biologics https://t.co/vEjQFPNHYx
I think 2018 was the year that belonged to psoriatic arthritis (although some may argue in favor of immune conditions induced by Checkpoint inhibitors). Many years ago the late Professor Verna Wright in Leeds (UK) was a lone voice for many years describing the clinical subtypes of Psoriatic arthritis as something distinctive from rheumatoid arthritis. For a long time we thought that the treatments for PsA were just the same as RA since we were
Cannbinoids are widely available and used for a variety of indications, but little is known about their safety and their potential for drug interactions. The Canadian Medical Journal has published a review of drug interactions with cannabinoids, many of which are mediated by cytochrome-P450 metabolism.

