Mateo Faxas et al. TriNetX study, propensity score matched. 3000 patients. Arrythmia risk is higher with IL-6i vs TNFi in diabetic RA patients. V Tachy (HR 1.4), PPM need (HR 1.4) significantly higher. AF, SVT, VF all numerically increased. @RheumNow #ACR25 Abstr#2283 https://t.co/U2Tk38Mobg

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Heydari-Kamjani et al. TriNetX study. 28973 PsA patients. IL-17i and IL-23i lower rates stroke, MI, DVT/PE than TNFi. IL-12/23i higher rate of stroke vs TNFi. @RheumNow #ACR25 Abstr#2363 https://t.co/fNHaxyYPCP

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Adding social risk factors to the mix Abstract 1917: WashU Rheumatology examined SRF screening in the clinic 🔹 50% screened once; 1/3 screened > 1 🔹 Core SRFs (finance, transport, housing, food) relatively stable 🔹 Biggest change over time: stress @RheumNow #ACR25 https://t.co/oKlwMZ77nB

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Is taking NSAIDs +TNFi better for the joints? Abstract 2359: In radiographic axSpA, NSAIDS + TNFi associated with -fewer syndesmophytes 36% vs 58% TNFi - no significant effect on hip structural changes - @RheumNow #ACR25

The CAR T engine doesn’t stop! LB04: Phase 1 bispecific CD19/BCMA CAR T in refractory autoimmune disease 🚗💥 ✅ Low AEs (mostly Gr 1–2 CRS, hematologic) 💪 Robust efficacy in lupus nephritis 🔄 Deep B-cell depletion → naïve B-cell repopulation @RheumNow #ACR25

Effect of air pollution in RA Prospective cohort 1000+pts w/ 12000+ visits Higher levels of pollution & specific size of particles PM25 asso w/ -10% higher odd of flare -Higher DAS CRP and CDAI Now the interesting pattern: PM25 exposure increases 3 weeks before flares https://t.co/MOskJzk05g

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Molina et al. 52 weeks of MANHATTAN study. Guselkumab vs second TNFi after failure 1st TNFi in PsA. MDA 52% vs 33%. Remission/LDA 67% vs 62%. @RheumNow #ACR25 Abstr#2373 https://t.co/qdtOlKLfNU

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Higashida-Konishi et al. RA. Insomnia and fatigue in >80%, depression in 13%. RA disease activity is associated with depression, fatigue, and insomnia. @RheumNow #ACR25 Abstr#2254 https://t.co/7SibPW6BBw

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CD19 counts during RTX maintenance therapy do NOT perform well in assessing the risk of relapse Interestingly, only younger age was associated with relapse in this retrospective study @RheumNow #ACR25 Abst 1766 https://t.co/crsFKJ0LnP

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In case you have a (gut) feeling something’s off… Abstract 2315: The gut microbiome in #SpA 🔬 ⬆️ Proteobacteria (incl. Escherichia spp) ⬇️ Firmicutes (“good” bacteria) Higher disease activity ↔️ lower alpha diversity @RheumNow #ACR25

Can AI predict who stops their RA meds? In older adults on b/tsDMARDs, interpretable ML found frailty, comorbidity & age top the list for nonadherence risk. @RheumNow #ACR25 Abstract#2287

Zavada et al. 52 patients. bDMARD therapy improves sexual function at 6 months in r-axSpA. Improvements in function, desire, satisfaction in those with baseline erectile dysfunction @RheumNow #ACR25 Abstr#2346 https://t.co/IUMGCFnXZh

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Konsta et al. Adding NSAID to TNF inhibits spinal but not hip radiograpic progress. 262 patients, TNF+NSAID 100, TNF alone 162. New syndesmophytes 36% vs 58%. ΔmSASSS-score/year 0.1 vs 0.7. No effect on progression of hip radiographs. @RheumNow #ACR25 Abstr#2359 #ACRBest https://t.co/k9j2M2E3ze

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Paging the pharmacist Abstract 1973: Dedicated clinic pharmacist -> benefits Tasks included: 🔹 74% PA support 🔹 55% patient education 🔹 40% medication management ~50% pts had clinically meaningful improvement Providers report ↑ care quality & ↓ admin burden @RheumNow #ACR25

Hojiej et al. Prevalence and Impact of lifestyle factors in PsA. Lifestyle factors impacted disease activity. Cumulative effect of increasing number of factors @RheumNow #ACR25 Abstr#2309 https://t.co/oDGQyLBRDO

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