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S American study of #SLE compared Latin American (LAM) vs European caucasian SLE pts - LAM had more myositis, hemolytic anemia, nephritis, Sm, Ro, RN

Dr. John Cush RheumNow

6 years 10 months ago
S American study of #SLE compared Latin American (LAM) vs European caucasian SLE pts - LAM had more myositis, hemolytic anemia, nephritis, Sm, Ro, RNP & more disease activity, hospital admissions, but damage index, mortality or co-morbidities https://t.co/o8hFQrCZp6
Biosimilar Tote-Board in Rheumatology:
4 Infliximab biosimilars - Inflectra, Renflexis, Ifixi, Avsola
5 Adalimumab biosimilars - Amjevita, Cyltezo, Hy

Dr. John Cush RheumNow

6 years 10 months ago
Biosimilar Tote-Board in Rheumatology: 4 Infliximab biosimilars - Inflectra, Renflexis, Ifixi, Avsola 5 Adalimumab biosimilars - Amjevita, Cyltezo, Hyrimoz, Hadlima, Abrilada 2 Etanercept biosimilars - Erelzi, Enticovo 2 Rituximab biosimilars - Truxima, Ruxience
FDA has approved Amgen’s infliximab biosimilar, Avsola (infliximab-axxq),for use in Crohns, UC, RA, AS, PsA and psoriasis, based on a 566 pt trial i

Dr. John Cush RheumNow

6 years 10 months ago
FDA has approved Amgen’s infliximab biosimilar, Avsola (infliximab-axxq),for use in Crohns, UC, RA, AS, PsA and psoriasis, based on a 566 pt trial in RA. This is the 4th infliximab biosimilar in the US, joining Inflectra, Renflexis, and Ixifi. https://t.co/nFhyMM1OnK
46 #RA pts on DMARDs +/- biologics received 3 part Hepatitis B Vaccination - those on biologics and DMARDs had less seroprotection vs controls (50% vs

Dr. John Cush RheumNow

6 years 10 months ago
46 #RA pts on DMARDs +/- biologics received 3 part Hepatitis B Vaccination - those on biologics and DMARDs had less seroprotection vs controls (50% vs. 100% [p = 0.02] and 69.7% vs. 100% [p = 0.09], respectively). HBV vaccine well tolerated & without flare https://t.co/3XuQhYquMy
A Canadian analysis shows that rheumatoid arthritis (RA) patients are more likely to receive biologic DMARDs earlier if they are younger, female, and living in urban areas closer to prescribers. However usage patterns were not uniform across patients and prescribers given similar disease characteristics in a population with identical health insurance coverage. 
BEST JOURNAL TITLE OF THE WK - "The Giants (biologicals) against the Pigmies (small molecules), pros and cons of two different approaches to the disea

Dr. John Cush RheumNow

6 years 10 months ago
BEST JOURNAL TITLE OF THE WK - "The Giants (biologicals) against the Pigmies (small molecules), pros and cons of two different approaches to the disease modifying treatment in rheumatoid arthritis." https://t.co/9ncBmDbd6B
Comparison of radiographic (r-axSpA) & non-radiographic axSpA (nr-axSpA) pts from the DESIR study shows a higher prevalence of males in r-axSpA, b

Dr. John Cush RheumNow

6 years 10 months ago
Comparison of radiographic (r-axSpA) & non-radiographic axSpA (nr-axSpA) pts from the DESIR study shows a higher prevalence of males in r-axSpA, but no significant differences in peripheral arthritis, extra-rheumatic Sxs, PROs, Sick leave between groups https://t.co/nIndsJuFCN
Those with prior partial knee arthroplasty (AKA medial unicompartmental knee arthroplasty) who undergo total knee replacement have a 3-fold higher ris

Dr. John Cush RheumNow

6 years 10 months ago
Those with prior partial knee arthroplasty (AKA medial unicompartmental knee arthroplasty) who undergo total knee replacement have a 3-fold higher risk of revision vs primary TKA. https://t.co/PIJICbfkoG
Achilles tendinitis Risk factors: 1) prior lower limb tendinopathy or Fx, 2) quinolones, 3) moderate alcohol, 4) cold weather training, 5) decr planta

Dr. John Cush RheumNow

6 years 10 months ago
Achilles tendinitis Risk factors: 1) prior lower limb tendinopathy or Fx, 2) quinolones, 3) moderate alcohol, 4) cold weather training, 5) decr plantar flexor strength, 6) abnormal gait, 7) lateral foot roll-over 8) CrCl <60 in heart transplant pts. https://t.co/AS05AjDJ2C
We all know that the microbiome in the gut may be very important for multiple immune diseases. However, new findings from the ACR, 2019 in Atlanta reinforce how important the interface is between the lungs and developing rheumatoid arthritis.
A report from Lancet Rheumatology shows that glucocorticoid use contributes to damage accrual in systemic lupus erythematosus (SLE) independent of disease activity.The authors undertook this study to evaluate the effects of steroid use in SLE, as it often confounds analyses of activity and damage.
TB is highly endemic in https://t.co/EbxAucKT9Y. S. African registry reports 97 TB cases in biologic users w/ TB rate 1240/100000 PYs vs zero in biolo

Dr. John Cush RheumNow

6 years 10 months ago
TB is highly endemic in https://t.co/EbxAucKT9Y. S. African registry reports 97 TB cases in biologic users w/ TB rate 1240/100000 PYs vs zero in biologic naive pts. 1/3 were extra-pulmonary. TB risk highest w/ TNFi Mabs (1683) vs 861 ETN or 681 other MOAs. https://t.co/VUNHVjzkex
The RheumNow Podcast is up! Monitoring Methotrexate Safety, Palmoplantar pustulosis, diet in SLE, enthesitis Rx, &amp; benefits of smoking cessation.

Dr. John Cush RheumNow

6 years 10 months ago
The RheumNow Podcast is up! Monitoring Methotrexate Safety, Palmoplantar pustulosis, diet in SLE, enthesitis Rx, & benefits of smoking cessation..... Listen here>> https://t.co/zoFp2vc7EB
Newly Dx #SLE patients have a 62% higher risk of hip fracture. Canadian matched cohort study of 5,047 incident SLE vs and 25,235 non-SLE showed more h

Dr. John Cush RheumNow

6 years 10 months ago
Newly Dx #SLE patients have a 62% higher risk of hip fracture. Canadian matched cohort study of 5,047 incident SLE vs and 25,235 non-SLE showed more hip fractures in SLE (HR=1.62 [95% CI; 1.06-2.48]). Implications for OP prevention in SLE patients? https://t.co/oDbYZPwMXD
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