The NEJM reports a randomized placebo controlled trial of nintedanib, a tyrosine kinase inhibitor, in systemic sclerosis patients with interstitial lung disease (ILD) resulted in less pulmonary decline, but had no effect on other features of systemic sclerosis.
Medicare and Truven MarketScan administrative data study (2006 through 2015) of rheumatoid arthritis (RA) undergoing arthroplasty found that while that the risks of perioperative infection was similar across biologics, the infection risk with glucocorticoid use, especially at > 10 mg/d, was significantly greater.
The Pharmacovigilance Risk Assessment Committee of the European Medicines Agency issued recommendations limiting the use of Xeljanz (tofacitinib) 10 mg twice daily in patients with ulcerative colitis in the EU.
The new recommendations are temporary while PRAC undertakes a review of all available evidence on the safety and efficacy of tofacitinib. The review follows warnings of an increased risk of pulmonary embolism (PE) and death from the U.S
Dr. John Cush RheumNow
7 years 5 months ago
Congratulations to Dr Ellen Gravallese, who has been awarded the Carol Nachman Prize for Rheumatology-the highest international honor for rheumatology research. She is the Myles J McDonough Chair in Rheumatology, & chief of Division of Rheumatology, UMASS https://t.co/pkv4uTzjVG
Dr. John Cush RheumNow
7 years 5 months ago
Smartphone pictures (taken by patients) can be very helpful. One study in 40 Pediatric dermatology patients showed an 89% concordance between clinic visit and virtual picture diagnosis. https://t.co/ogk3UVIsJI
Dr. John Cush RheumNow
7 years 5 months ago
100 pts with oligoarticular inflam arthritis in India: Causes= periph SpA(n 37), axial SpA(11),TB (19), brucella (6), septic arthritis (6), gout (5), RA(5), NTMycobacteria (2), SLE (2), chikungunya (2), 1 Ea. w/ ALL, sarcoid, pachydermoperiostosis https://t.co/6fdxWnWENl
Dr. John Cush RheumNow
7 years 5 months ago
Large study from OTIS on PsA and AS shows an increased risk for adverse pregnancy outcomes - including preterm delivery (RR 1.81, 3.82) & Cesarean delivery (RR 1.63, 5.82). Active disease & steroid use may also increase these risks. https://t.co/E10SEq32IO
Analysis of a large US observational rheumatoid arthritis (RA) patients finds that opioids, SSRIs and glucocorticoids were associated with increased risk of fracture in RA, whereas statins and TNFi had a decreased vertebral fracture risk.
Dr. John Cush RheumNow
7 years 5 months ago
DECT is most accurate in diagnosing established gout - review of 10 studies shows a pooled (95% CI) sensitivity of 0.81 (0.77, 0.86) and specificity of 0.91 (0.85, 0.95), respectively. W/ short disease duration (⩽6 wks), sensitivity 0.55 and spec 0.89 https://t.co/DOdejOZGcv
Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com
Dr. John Cush RheumNow
7 years 5 months ago
Review of Factors Contributing to Functional Outcomes after Knee replacement includes: Weight, pain & smoking (increase post-op complications), pain, infection (2% w/in 1st 90days), post-operative range of motion and (severity of) the OTHER knee. https://t.co/mKe8EQnk8q
Dr. John Cush RheumNow
7 years 5 months ago
My talk on Infection Prevention and Management with Newer Agents is one of more than 30 talks now available at RheumNow Live On Demand - and registration is free. #rheumed https://t.co/1jGiIQXvua
It his often said that gout and rheumatoid arthritis (RA) cannot coexist and where confusion exists, a good history and testing for serum urate (SUA) and rheumatoid factor (RF) can usually clarify the dominant disorders. A recent study shows that hyperuricemia and gout are uncommon in RA, but when present shows an increased risk of comorbidities and cardiovascular (CV) mortality.
