RheumNow Live Preview with Dr. Kenneth Mathis
Preview of Dr. Kenneth Mathis's lecture on Joint Replacement: Where We've Been, Where We're Going at the 2019 RheumNow Live meeting.
Dr. John Cush RheumNow
7 years 6 months ago
3002 UK study shows that statin (atorvastatin) use in RA is safe and effective - resulting in significant reduction in Cardiac/MACE events (HR 0.60), LDL (HR 0.77) and CRP and confers a risk reduction similar to that seen in other populations https://t.co/Zl2KaK12P5
Dr. John Cush RheumNow
7 years 6 months ago
Metanalysis shows NSAIDS increase rates of delayed union or nonunion (OR 2.07; 1.19 to 3.61) in adults with fracture, osteotomy, fusion surgery; but not in pediatrics (OR 0.58) or with low dose/short duration NSAID exposure (OR 1.68). https://t.co/0tM8OFLhzt
Dr. John Cush RheumNow
7 years 6 months ago
UK NHS study shows RA patients have a 1 in 5 lifetime risk of knee and hip replacement. 13 961 RA pts fins a 22% (TKR) and 17% (THR) risk following a RA Dx (for an avg 64 yr F, nonsmoker, BMI27). Risk is even higher in younger patients. https://t.co/asOVrRUZLx
AbbVie has announced that the US FDA has granted the approval of Skyrizi (risankizumab-rzaa) for the treatment of moderate to severe plaque psoriasis.
Skyrizi is an interleukin-23 (IL-23) inhibitor that was also recently approved in Canada and Japan. Skyrizi is the third IL-23 inhibitor (behind guselkumab [Tremfya] and tildrakizumab [Ilumya]) to be approved in the last year.
A small prospective study has shown that ustekinumab is safe and effective in Behçet's disease (BD) with recurrent oral ulcers (OU).
RheumNow Live Preview with Dr. Paul Monach
Preview of Dr. Paul Monach's lecture on Advances in Diagnosis and Treatment of GCA at the 2019 RheumNow Live meeting.
In October 2018, the National Institutes of Health (NIH) convened a workshop to address the "Appropriate Use of Drug Therapies for Osteoporotic Fracture Prevention"
A longitudinal study of systemic lupus erythematosus (SLE) from the Toronto Lupus Clinic has shown that mortality has decreased over time.
The cohort incuded 1732 SLE patients followed between 1971 and 2013. The cause of death was gleaned from death certificates, autopsy reports, hospital records or the records of the family physicians.
Dr. John Cush RheumNow
7 years 6 months ago
Do you use PJP prophylaxis w/ Bactrim in RA pts? 2640 RA pts found only 19 cases of pneumocystis pneumonia. Risk factors were high dose MTX (OR 4.5), >65 yrs (OR 3.7), ≥2 ISPs (3.7), prednisolone ≥5 (OR 12.4) - a combo of these has a 2.3-5.8% riskof PJP. https://t.co/5Pf2FskE30
Dr. John Cush RheumNow
7 years 6 months ago
Should you check hydroxychloroquine levels in your #SLE patients? I do not but probably should in patients who are not in remission as nonadherence to HCQ may be as high as 50%. This is routinely available. https://t.co/UkxjMh3lQz
Dr. John Cush RheumNow
7 years 6 months ago
What is your best therapy when treating calcinosis cutis? (or write in your Rx)
Dr. John Cush RheumNow
7 years 6 months ago
CORRONA study of 880 RA pts w/ hx of Solid cancer shows many on biologics following Dx. 42% were on biologics/tsDMARDs in the 12 mo before cancer. Post CA 31% were on same Rx, 5% switched biologics &10% started a biologic, the majority starting TNFi (54%). https://t.co/PjjQvFVnsI
Patients with RA, but without CV disease, who were treated with atorvastatin appeared to experience cardiovascular (CV) benefits similar to what has been observed in other populations, with a risk reduction of approximately one-third, according to a large, but prematurely terminated, trial in the U.K.
Dr. John Cush RheumNow
7 years 6 months ago
Autoimmune dz is 4x more common in women. Studies in mice show females have increased expression of epidermal VGLL3 - known to drives proinflammatory gene expression cutaneous lupus, B cell expansion, auto-AB production, immune complex deposition. https://t.co/Le1yEBoIoR

