A study of patients undergoing arthroscopic rotator cuff repair shows that corticosteroid injections in the month prior to surgery are associated with a significantly increased risk of surgical site infection.
A study from the British Society for Rheumatology Biologics Register (BSRBR-RA) demonstrates that polypharmacy is a predictor of lower treatment responses and more serious adverse events (SAEs) in rheumatoid arthritis (RA) patients.
Dr. John Cush RheumNow
7 years 6 months ago
NXP-2 Abs Are associated with your metal myositis and a cancer risk but also associated with calcinosis. Rheumatology 2019; Mar 16 https://t.co/8qTmZpo6Cj
The goal of SLE treatment is remission or low disease activity and flare prevention. Hydroxychloroquine is recommended in all patients with lupus, at a dose not exceeding 5 mg/kg real body weight. Glucocorticoids (GC) should be minimised to less than 7.5 mg/day (prednisone equivalent). Appropriate initiation of immunomodulatory agents (methotrexate, azathioprine, mycophenolate) can be tailored to the clinical scenarios and may allow for tapering
Dr. John Cush RheumNow
7 years 6 months ago
Comparing fibromyalgia, PsA, Psoriasis Pts - FM has more entheseal tenderness (92%) than PSA (66%) and PSO (59%). However with ultrasound, entheseal involvement were more frequent in PsA & psoriasis (~90%) vs FM (75%). What? US enthesitis in FM? https://t.co/wNBQEB3j0O
Dr. John Cush RheumNow
7 years 6 months ago
Lateral wedge insoles are often used medial knee OA. Study of 63 preselected pts shows a significant pain reduction (vs neutral soles) but mean difference was 0.7 on 0–10 scale; thus benefitting only a minority of pts https://t.co/7SK7Cl1Uft
Dr. John Cush RheumNow
7 years 6 months ago
TARA study takes 189 #RA pts in remission on combo Rx and tapers either the csDMARD or biologic. At 1 year, flare rates were similar 33% (DMARD) vs 43% (biologic). Tapering TNF inhibitors was superior, but would have saved more $$. https://t.co/XxZbx5zjCC
A French cohort study of 625 systemic sclerosis (SStc) patients has found a significantly increased mortality risk that can be predicted by common clinical variables.
In addition to a multicenter prospective study, investigators performed a metanalysis on SSc standarized mortality ratios (SMR) and hazard ratios of prognosis factors.
A novel study has shown that intraarticular therapy with high‐purity synthetic trans‐capsaicin (CNTX‐4975) for chronic knee osteoarthritis (KOA) was associated with significant relief of knee pain.
Researchers found no protective effect of smoking against knee osteoarthritis (OA), according to a new longitudinal cohort study of 620 individuals with meniscal tears treated at five sites in Denmark. An inverse association between OA and smoking had been suggested by several previous studies and a recent meta-analysis.
RheumNow Live Preview with Dr. Eric Ruderman
Preview of Dr. Eric Ruderman's lecture on What's the Deal with Non-radiographic Axial Spondyloarthritis? at the 2019 RheumNow Live meeting.
Dr. John Cush RheumNow
7 years 6 months ago
The price of new osteoporosis drug Evenity (romosuzumab; sclerostin inhibitor) is $1,825/mo. or $21,900/Yr; Just FDA approved for post-menopausal OP at high risk for Fx . Amgen estimates Evenity to be 34-74% lower than Tymlos & Forteo. https://t.co/lYHyukTRPw
Dr. John Cush RheumNow
7 years 6 months ago
Immunomonitoring with microarrays from the SLE PROMISE pregnancy study shows that adverse outcomes (preeclampsia) can be identified by quantifying plasma cell, interferon and neutrophil RNA levels during the pregnancy https://t.co/81cBGA3hKx.
Dr. John Cush RheumNow
7 years 6 months ago
Peripheral Nervous system involvement in lupus is uncommon at 6.9% - 1/3 were polyneuropathy, 1/3 were cranial neuropathy and few mononeuritis. Risk greatest with age, lupus disease activity and damage https://t.co/0JxhcrZQb1
The advent of "big data" and "-omics" technologies offers hope that clinicians will soon have better diagnostics for systemic lupus erythematosus, rheumatologists here were told.

