Dr. John Cush RheumNow
7 years 11 months ago
Frankincense is derived from Boswellia plants. Boswellia serrata is an Ayurvedic purported to be anti-inflammatory; inhibits 5-lipoxygenase & possibly prostaglandins, Pilot studies in OA have shown significant pain relief and improved physical function https://t.co/OPxal73aIF
Dr. John Cush RheumNow
7 years 11 months ago
BMJ metanalysis of toxicity w/ checkpoint inhibitors shows risks w/ atezolizumab (hypothyroid, N/V) , pembrolizumab (arthralgia, pneumonitis, hepatic tox), ipilimumab (skin/GI/renal), nivolumab (milder, endocrine); Nivolumab (best safety w/ lung CA) https://t.co/qzcehpLe4S
Dr. John Cush RheumNow
7 years 11 months ago
What works in Dactylitis? Literature review suggests ustekinumab, ixekizumab, adalimumab, and apremilast are efficient. Secukinumab, clazakizumab, abatacept, and tofacitinib were promising. Brodalumab was ineffective https://t.co/SLPcjBaNAv
JAMA reports on a randomized clinical trial of 202 adults with acute low back pain showing the addition of intensive patient education failed to improve pain outcomes.
This randomized, placebo-controlled clinical trial recruited patients from general practices in Sydney, Australia, between 2013 - 2015. Patients had to have acute low back pain of fewer than 6 weeks’ duration.
Dr. John Cush RheumNow
7 years 11 months ago
Analysis of Natl Inpatient Sample database (1998-2014) compared outcomes in 87605 SLE pregnancies vs matched cohort: found SLE had more C-section, IU fetal death, Pre-eclampsia, VTE, CKD, HTN, longer stays Presented by Dr. Bella Mehta #ACR18 Abst 1852 https://t.co/iYicIbOlxP
Dr. John Cush RheumNow
7 years 11 months ago
Durkan Test for CTS is when the Examiner presses the thumbs over carpal tunnel and holds pressure for 30 seconds. The onset of pain or paresthesia in the median nerve distribution within 30 seconds is a positive result . https://t.co/1wlJWzX68H
Dr. John Cush RheumNow
7 years 11 months ago
Do you know who patients perceive to be a "great doctor"? Just listen - its always someone who shows they care and/or someone with a personality. Dispassionate, know-it-all service isnt well received!
Dr. John Cush RheumNow
7 years 11 months ago
Study of 512 pts shows when testing for Carpal Tunnel syndrome Thenar atrophy & sensory loss were highly specific, but thenar atrophy had lowest sensitivity (22%) & Durkan test highest (96%). Tinel had lowest specificity 40.9% and NPV 59.1%. https://t.co/Wi8qxNSxIg
Last July, the Centers for Medicare & Medicaid Services (CMS) proposed new E/M guidelines for office visits with physicians. It issued the final guidelines on November 1, with a few tweaks. Implementation was delayed until 2021 (from 2019), possibly due to overwhelming opposition from physicians.
Boston researchers have found that in a large cohort study of patients receiving rituximab (RTX), most were not being monitored for hypogammaglobulinemia, despite the observed significant increase in severe infections and increased mortality in RTX treated patients.
Dr. John Cush RheumNow
7 years 11 months ago
Korean claims data analysis shows intestinal Behcets disease is associated with a 24-34 fold increased risk of hematologic malignancy (esp leukemia, myelodysplasia) vs population. BD Women not men) have an overall higher cancer risk (SIR 4.27) https://t.co/Ik6KdEGz7u
Analysis of the FDA Adverse Event Reporting System data examined the association between statins' musculoskeletal adverse events (MAEs).
Review of the data shows that atorvastatin and rosuvastatin (with strong low‐density lipoprotein cholesterol‐lowering effects) had a higher risk and a faster onset of MAEs when compared with simvastatin.
New recommendations have been published in the Journal of Athletic Training on the management of patellofemoral pain (PFP).
Dr. John Cush RheumNow
7 years 11 months ago
N of 1 trial of On-Demand Sildenafil in Raynauds (multiple crossovers in single patient) shows in 38 pts there was a 90% chance of response w/ sildenafil superior to placebo; but substantial heterogeneity of patient responses limits the clinical relevance. https://t.co/FCllFm1FLR
Dr. John Cush RheumNow
7 years 11 months ago
JAMA Metanalysis shows there is limited evidence showing the benefit of reduced dietary salt intake in heart failure patients. https://t.co/EsxApEUsbe

