In RCT of RA pts in remission/low disease activity, spacing ozoralizumab (next gen TNFi) or reducing MTX led to more flares vs continued tx; but most pts in remission at baseline maintained LDAS. Remission matters for subsequent Tx reduction. @RheumNow #EULAR2025 #LB0006

Suppression of inflammation fire 🔥 in #axSpA may prevent subclinical atherosclerosis progression ❤️ 🔺️90 patients 🔺️74% achieved LDA at 12 mo 🔺️Carotid plaque progression was higher in non-LDA group POS1311 #EULAR2015 @RheumNow

#EULAR2025 Abstr#LB0004 Phase 2 RCT of first-in-class, Enpatoran, TLR7/8-i in active #SLE despite SOC (Cohort B) reported nominal improvement in BICLA but no dose-dependent response. Greater effects seen on active CLE, high IFN-GS or high dose GC. No major safety signal @RheumNow https://t.co/aX4ier0rAy

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RheumNow’s expanded coverage of the #EULAR2025 Annual meeting is sponsored in part by Johnson & Johnson and UCB. All content chosen by RheumNow & its Faculty.

Enpatoran (TLR7/8 inhibitor) in SLE & CLE - helps skin, others? - suppresses interferon lowest dose was highest response though (upsetting primary endpoint) Promising, watch for the ph3 No photos allowed, but official slides: https://t.co/1yX6XrYvKH #EULAR2025 LB0004 @RheumNow

• Randomised, Placebo-Controlled Phase II Study of Oral Enpatoran, a First-in-Cla…

APEX study Ph3 RCT Guselkumab In BioNaive active PsA w/ erosions>=2 wk 24 ACR20 GUS Q4W 67% Q8W 68% vs PBO 47% Less Rx progression in both Q4W & Q8W vs. PBO #EULAR2025 @RheumNow LB0010 https://t.co/OVDWWECtOZ

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💉Early results from a dose-escalation trial of novel CD19xCD3xCD28 trispecific antibody (CC312) in refractory #SLE show no ICANS or ≥G2 CRS, rapid B cell depletion & 100% SRI-4 response (n=5). @RheumNow #EULAR2025 #LB0007 #CART

#EULAR2025 Abstr#LB0005 Phase IIb RCT in moderate #Sjogren reported significant reduction in ESSDAI at WK24 from BL in HCQ-Leflunomide vs PBO. CRESS & STAR improved. No significant difference in UWS, Schirmer, & ESSPRI. Future work: cohort of high symptom burden @RheumNow

The relation between RA, comorbidities and presenteism NRAS survey 891 RA pts 75% had at least one comorbidity Absenteeism more likely if One OR = 1.68 or Two OR = 2.26 comorbid conditions In particular Anxiety OR = 2.39 Depression OR = 1.75 Osteoarthritis OR = 1.85 Back

The transformative potential of integrating ePROMs into AI care pathways 🔺️Study by Dr Antoni Chan et al. achieved a new-to-followup ratio of 1:2.5 outperforming the national average of 1:4.2 🔺️Without losing contact with pts @synovialjoints POS1271 #EULAR2025 @RheumNow https://t.co/z3jO3ADHR1

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🦵🏻SAP-001, a novel uricosuric targeting a non-URAT1 renal transporter, lowered sUA <6 mg/dL in up to 79% of patients with refractory #gout on b/g xanthine oxidase inhibitor. >50% on 60 mg/day reached sUA <3 mg/dL. 💊Potential new oral ULT option. @RheumNow #EULAR2025 #LB0008 https://t.co/dfY1V5sHSh

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Why do Rheumatologists shift to private practice? Are there gender based differences? A survey of 100+ European rheumatologists Female 🚺 rheumatologists: Leave hospital earlier At a lower hierarchical level Reasons for leaving: nightshifts unfair promotion decisions

EULAR PtC for definition of #TR Trt Refractory) #Psoriatic_Arthritis #D2M 1️⃣ Failure >= 2 b/tsDMARDs 2️⃣ Problematic 3️⃣ Evidence of persistent dis + 4️⃣ Exclude drivers like comorbidities & psychosocial factors 🔺️Exclude failure due to Side Effets/CI #EULAR2025 @RheumNow https://t.co/ULD2Xe6p6A

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Will climate change impact rheumatological care? #EULAR2025 @rheumnow Especially larger cities are are affected more. Need to worry about comorbidities https://t.co/KhTyAssGeI

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Imagine #Barcelona with an additional 8 degrees in summer 🔥 🔥🔥 Session: Disaster Medicine - Impact of climate change, heat, and global insecurity #EULAR2025 @RheumNow https://t.co/1TqlBJtoZD

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