29% of new-onset psoriasis pts in Stockholm cohort developed PsA over 9,255 person-years. Two prediction models (AUC 0.804) identify: ➡ who to refer ➡ who will progress Key predictors: HLA-B27, CRP, enthesitis, arthralgia. @RheumNow #EULAR2025 #OP0178:

The definition of MAS. MAS is secondary HLH. Other causes of secondary HLH are infections, malignancy and iatrogenic. Georgin-Lavialle S @RheumNow #EULAR2025 https://t.co/CpB78JBlVJ

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Clinical Pearl's for #MAS Infections are still the most common cause. Next is malignancy... Then other causes like autoimmunity.. Ask a detailed history ! Sometimes check with the family when the pt can't give history.. #EULAR2025 @RheumNow https://t.co/fepercz5Af

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Total serum IL 18 can help instead of CDC42 or NLCR4 genetic testing in #MAS Several monogentic mutations in primary HLH- these panels can be available.. #EULAR2025 @RheumNow

Age of onset is really important when thinking about #MAS Primary HLH more frequent in pediatric population. But can continue to adulthood. #EULAR2025 @RheumNow https://t.co/J7xmTiQiwr

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MAS can be triggered by infections in VEXAS syndrome. The threshold is reached leading to a hyperinflammatory state Georgin-Lavialle S @rheumnow #EULAR2025 https://t.co/NKLL75rOgP

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#infections in #JAKi @drdavidliew #JAKi sl ⬆️ infection risk vs #TNFi ⬆️HZ w JAKi JAKi same risk w #latent #TB #LTBI and new TB ⬇️in JAKi v bDMARDs He didn’t discuss TYK2i Reassuring - risk⬇️ over time for infection @RheumNow #EULAR2025 @eular_org JAKi & infection https://t.co/KVsY2gXVkQ

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Management of HLH/MAS and modes of action of advanced therapies Jessica Manson @RheumNow #EULAR2025 https://t.co/Op3u53ZXeK

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JAKi: expanding RMD indications—but important safety concerns to consider ⚠️ Cancer: Neutral vs MTX/placebo, ↑ risk vs TNF ⚠️ Infection: ↑ with age, disease activity & GC use—not uniformly higher with JAKi 🗣️ Patients rank infection risk as top concern @rheumnow #EULAR2025 https://t.co/RJRDWQjqNC

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Age & dose ⬆️ infections in JAKi Not all JAKi are created w equal risk ⁦@RheumNow⁩ ⁦@eular_org⁩ #EULAR2015 ⁦@drdavidliew⁩ #JAKi & #infection https://t.co/F7zLUBuzJR

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Stabilize the pts with HLH with steroids when still trying to figure out the diagnosis of #HLH/ #MAS Many drugs can be used...but important to balance infection risk with immunosuppression These are critical pts. Be vigilant.. #EULAR2025 @RheumNow https://t.co/id4ae3SWtj

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3 Fs of diagnosis of #HLH -Fever -Ferritin -Falling blood count Raising awareness is the key! Especially in rare diseases like this where the morbidity and mortality is super high! Collaboration between specialists help HLH networks will be helpful like this @RheumNow #EULAR2025 https://t.co/HWbvIma3yx

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In #axSpA post #TNFi-IR What to use next? 👇 #ATTRA registry 90% #SpA on #bDMARDs are captured Comparison of TNFi to ▶️ 2nd TNFi vs #IL17i ▶️No diff in #retention ✅better #BASDAI and other outcomes w TNFi! ❎less safety 🤔 #EULAR2025 @RheumNow @eular_org Abst#POS0116 https://t.co/7mqFfD4Amf

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#Cancer is not ⬆️in JAKi vs #bDMARDs in #rheumatoid #arthritis When adjusted for #confounders #JAKPOT data Now you see it (unadjusted ⬆️risk) Now you don’t (adjusted =#malignancy) JAKi vs bDMARDs in RA EULAR2025 @RheumNow @eular_org #JAK it out! new perspective on JAKi https://t.co/wCQ3dHNAVa

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Rheumatology #AI to optimize rheumatology triage. Only 53 percent correlation between the AIs diagnosis with rheumatologists final diagnosis. Not sure if we want 47 percent pts to drop off...without a chance for diagnosis? #POS0883 #EULAR2025 @RheumNow https://t.co/UWsCHG00t1

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