TheDaoIndex KDAO2011
2 years 7 months ago
Which IL17i to choose? Depends on the domain
Dr. Armstrong: For the skin, the studies show brodalumab, ixekizumab and bimekizumab are superior to secukimumab for #psoriasis
Dr. @AlexisOgdie noted we don't see much differences in these IL17i for the joints.
#RNL2024 @rheumnow
Richard Conway RichardPAConway
2 years 7 months ago
The differences do appear to relate to actual treatment specific differential response. As well as no difference with JAKi, there seems to be no difference in placebo response @lihi_eder @RheumNow #RNL2024 https://t.co/7H4KRvd6WG
Richard Conway RichardPAConway
2 years 7 months ago
Many advanced treatments appear to work less well in female patients with PsA, but JAKi seem to not demonstrate this phenomenon. Not sure what to do with this data in clinical practice but it is certainly intriguing @lihi_eder @RheumNow #RNL2024 https://t.co/GDrg715ctg
Dr. Rachel Tate uptoTate
2 years 7 months ago
@AlexisOgdie @_AprilArmstrong @lihi_eder are the amazing “Hot topics in PsA” panelists. #RNL2024 @RheumNow #womenforthewin https://t.co/6V2QyGJM98
Dr. Rachel Tate uptoTate
2 years 7 months ago
Dr. Lihi Eder discusses the differences between sex and gender.
Sex is a biologically-based construct defining differences between male and female
Gender has socio-cultural aspects of being a man, woman, or other AND has effect on social norms/expectations
BOTH are important to… https://t.co/iceTS0w5LY https://t.co/slSQMwF91J
Dr. Rachel Tate uptoTate
2 years 7 months ago
Differences in PsA:
Women tend to have higher pain scores with lower pain thresholds and are more likely to report "diffuse pain" compared to men. Keep this in mind with your assessments.
Remember mimics of sacroiliitis including osteitis condensas ilii. Look at the imaging below… https://t.co/AUjkQwfSuk https://t.co/5iXx5cxm4U
Dr. Rachel Tate uptoTate
2 years 7 months ago
BASDAI tends to be higher in women while there is no appreciable difference in ASDAS scoring in men compared to women.
Dr. L. Eder believes this could be due to the pain scoring in both indices.
#RNL2024 @RheumNow @lihi_eder https://t.co/i7XPenrmGG
TheDaoIndex KDAO2011
2 years 7 months ago
Did you know the majority of lecturers at #RNL2024 are women? #StrongWomenLeaders @ACRheum #RNL2024 #WomenChangingLives @rheumnow https://t.co/0TO8XUhhg5
Dr. Rachel Tate uptoTate
2 years 7 months ago
With regard to SpA patient journey:
On average, women are diagnosed 2.3 years later than men.
Additionally, women tend to have more visits to rheumatology to reach diagnosis of PsA, AS, and RA!
Remember your inherent bias along with sex/gender disparities.
Dr. L. Eder… https://t.co/o0Hv3NrXpB https://t.co/vsMN3HkSv6
Dr. Rachel Tate uptoTate
2 years 7 months ago
Did you know?
There is very limited reporting of sex-disaggregated RCT results, data necessary from an FDA standpoint. Dr. L. Eder points out the importance of this data from a clinical standpoint.
Let's do better!
#RNL2024 @RheumNow @lihi_eder https://t.co/3FETZZWt0B
Richard Conway RichardPAConway
2 years 7 months ago
This is the risk. We have to be aware and better at this in order to serve our female patients better @lihi_eder @RheumNow #RNL2024 https://t.co/7JIDtlSGXh
TheDaoIndex KDAO2011
2 years 7 months ago
The panel addresses the question about using combination biologics and combo tsDMARDS + biologic. These combos are being studied. The panel noted combo apremilast +biologic is pretty commonly used appears to be effective and safe. #RNL2024 @rheumnow https://t.co/EeIlhJiDZU
TheDaoIndex KDAO2011
2 years 7 months ago
Dr. Eder noted in her metanalysis of treatment efficacy in PsA based on gender – women had poorer response to treatments; the placebo effects are the same between men and women, suggesting a biologic mechanism and rather than a “psychosomatic” effect. #RNL2024 @rheumnow https://t.co/3H2Nfamg70
Richard Conway RichardPAConway
2 years 7 months ago
My volume of referrals for OCI or degenerative disease (or sometimes completely normal SI joints) read as "sacroiliiitis" really does seem to have been increasing lately @lihi_eder @RheumNow #RNL2024 https://t.co/vksNCaADck
TheDaoIndex KDAO2011
2 years 7 months ago
👉“Eighty percent of drugs withdrawn from the market pose greater risk for women.” – Dr. Eder #RNL2024 @rheumnow #genderDifferences https://t.co/RZrIdvecbY
