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An Interview with Kevin Winthrop: Three Questions About COVID 19

Drs. Jack Cush and Kevin Winthrop discuss COVID 19 at

Dr. John Cush RheumNow

2 years 10 months ago
An Interview with Kevin Winthrop: Three Questions About COVID 19 Drs. Jack Cush and Kevin Winthrop discuss COVID 19 at 2023 ACR Convergence in San Diego, CA. https://t.co/UL8q356G3i https://t.co/wWsEHz9obA
JAKi and TYK2i: What/when to use?

You can see that the JAKi/TYK2i have both approved or potential seropositive and ser

Dr. John Cush RheumNow

2 years 10 months ago
JAKi and TYK2i: What/when to use? You can see that the JAKi/TYK2i have both approved or potential seropositive and seronegative indications. There are also improvements in PsO for the class and studies in CTDs. It is difficult to know which to choose https://t.co/uid38oFBXP https://t.co/gLJfJNi2Jh
The problem with having therapies that work is that you then have to figure out what to do with them. You cannot hide behind a shrug of the shoulders, or the ambiguity of therapeutic inadequacy. The question that follows the presence of a therapy is the question as to how to best use it. GCA and PMR are at the stage in the growth of their therapeutic development where this problem is moving to the front of mind, and it made for a fitting topic
Here's what I learned at ACR23 that will change the way I practice in rheumatoid arthritis. 
Swedish national cohort study cohort study suggests #RA pts at incr risk for Autoimmune thyroid Dz, but decreases after

Dr. John Cush RheumNow

2 years 10 months ago
Swedish national cohort study cohort study suggests #RA pts at incr risk for Autoimmune thyroid Dz, but decreases after RA Dx & Rx. n=13,731 RA vs 63,201 matched pop. controls. Lower rates AITD w/ biologics & TNFi (HR 0.54, 0.67) https://t.co/ZfputgDJQE https://t.co/Z1r0eGFcX9
Last chance for early bird savings! Our early bird special closes on 11/30. Join us for RheumNow Live THIS JANUARY!

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Dr. John Cush RheumNow

2 years 10 months ago
Last chance for early bird savings! Our early bird special closes on 11/30. Join us for RheumNow Live THIS JANUARY! https://t.co/uD01S8rgrh https://t.co/29u3wz5PHK
National pharmacovigilance database review (1992 to 2021) identified 2217 "Falls", most serious, most in women (61%), &a

Dr. John Cush RheumNow

2 years 10 months ago
National pharmacovigilance database review (1992 to 2021) identified 2217 "Falls", most serious, most in women (61%), & 38% in 18–64 yr olds. Falls attributed to immunomodulators (17%), 24% Fxs & 1 in 7 classified as adverse drug rxns (343) https://t.co/tpUPDc8x09 https://t.co/jdssH7oCjF
UK study 336 GCA pts shows after 12 mos of tocilizumab, TCZ stopped (w mean pred 2mg/d) & GCA flares at 6, 12 &

Dr. John Cush RheumNow

2 years 10 months ago
UK study 336 GCA pts shows after 12 mos of tocilizumab, TCZ stopped (w mean pred 2mg/d) & GCA flares at 6, 12 & 24 mos was 21%, 35% & 49% respectively; requiring prednisolone dose increase to 20 (10-40) mg/day (34% were major relapses) https://t.co/EZ78ciNK0R https://t.co/R1qFsvnhoF
"Protein kinases: drug targets for immunological disorders". Great full-read review from J Shea et al. Reviews Hx, biolo

Dr. John Cush RheumNow

2 years 10 months ago
"Protein kinases: drug targets for immunological disorders". Great full-read review from J Shea et al. Reviews Hx, biology, clinical use and safetey of Kinase targeted therapy. https://t.co/qBc0ng1Z9h https://t.co/Qm8PFpNxQF
NEJM Clinical Images: Scleromyxedema (cutaneous mucinosis w/ a paraproteinemia).53-yoM w/ itchy rash, Raynauds, dysphagi

Dr. John Cush RheumNow

2 years 10 months ago
NEJM Clinical Images: Scleromyxedema (cutaneous mucinosis w/ a paraproteinemia).53-yoM w/ itchy rash, Raynauds, dysphagia, burning dysesthesia hands; Waxy papules across forehead & hands w/ skin thickening & finger contractures. Skin Bx & SPEP done https://t.co/vkpYGNd3Uw https://t.co/T5gVPRBrhh
Palliative Rheumatology
Cancer and TNF inhibitors

Cancer risk minimisation is a high priority for people with rheumatic diseases, as it is for

Dr. John Cush RheumNow

2 years 10 months ago
Cancer and TNF inhibitors Cancer risk minimisation is a high priority for people with rheumatic diseases, as it is for the general population. Tumor necrosis factor inhibitors (TNFi) have a long history of association with cancer risk discussions https://t.co/iWnBTqX1eV https://t.co/lDEyM0c2yo
The possibility of withdrawing DMARDs after patients achieve remission has been in our minds for a while. Yet when our patients ask whether it is a good idea to taper or stop their DMARD when they are doing well, most of us don’t have a black or white answer for them. The arrival on the market of several biosimilars and very reassuring long term safety data with bioDMARDs also provides encouraging prospects for longer term exposure.
How early is early in psoriatic arthritis? Is there a window of opportunity for treatment in PsA to ensure optimal ou

Dr. John Cush RheumNow

2 years 10 months ago

How early is early in psoriatic arthritis? Is there a window of opportunity for treatment in PsA to ensure optimal outcomes? https://t.co/jHrA1M05Qr https://t.co/jcU13Y4CRm

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