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Ivarmacitinib (selective JAK1 inhibitor) significantly improved ASAS40 vs placebo in nr-#axSpA(39.7% vs 24.8%; p=0.006)

Antoni Chan MD (Prof) synovialjoints

3 months 3 weeks ago
Ivarmacitinib (selective JAK1 inhibitor) significantly improved ASAS40 vs placebo in nr-#axSpA(39.7% vs 24.8%; p=0.006) at 12 weeks, sustained to 24 weeks. Another oral option for non-radiographic disease. Abstr OP0237 @RheumNow #EULAR2026
DR JOHN STONE gives Overview
Of
#IgG4

New non B cell depleter
#obexelimab N=194 in RCT

To add to B cell depletion w

Janet Pope Janetbirdope

3 months 3 weeks ago
DR JOHN STONE gives Overview Of #IgG4 New non B cell depleter #obexelimab N=194 in RCT To add to B cell depletion w #Inebilizumab Off label but used also #Rituximab #steroids #Immunesuppressives Other investigational drugs Ex #JAKi #EULAR2026 @RheumNow #OP018 #RULARbest https://t.co/Y4saGYcdww
Tofacitinib in Early AxSpA
Presented at EULAR 2026 London, Brepocitinib dual TYK2/JAK1 inhibitor with successful Phase 3 VALOR trial demonstrating significant improvement in skin and muscle symptoms in dermatomyositis (DM).
πŸ”¬ Can baseline T cell phenotype predict PsA treatment response?

COLIPSO cohort (n=17): YES!

Higher Treg & act

Nelly ZIADE πŸ€ Nellziade

3 months 3 weeks ago
πŸ”¬ Can baseline T cell phenotype predict PsA treatment response? COLIPSO cohort (n=17): YES! Higher Treg & activated CD4+ cells predict DAPSA & joint improvement #POS0083 #EULAR2026 @RheumNow https://t.co/UIs6LXAWAY
🧬 Does spine vs knee enthesis differ immunologically?

Translational scRNAseq study: YES!

Spine produces more IL-2

Nelly ZIADE πŸ€ Nellziade

3 months 3 weeks ago
🧬 Does spine vs knee enthesis differ immunologically? Translational scRNAseq study: YES! Spine produces more IL-23 but shows attenuated IL-17 response vs knee #POS0084 #EULAR2026 @RheumNow https://t.co/itFrLEXSzZ
πŸ” Are 2025 ASAS-SPARTAN criteria valid in early axSpA?

SPACE cohort (n=669):

HIGH specificity (97.5%) but LOWER s

Nelly ZIADE πŸ€ Nellziade

3 months 3 weeks ago
πŸ” Are 2025 ASAS-SPARTAN criteria valid in early axSpA? SPACE cohort (n=669): HIGH specificity (97.5%) but LOWER sensitivity (60%) vs 2009 criteria (83%) #OP0239 #EULAR2026 @RheumNow https://t.co/9wNbtcbP0l
A Field Whose Time Has Come: Launching the EULAR Study Group on Geriatric Rheumatology

EULAR launches a Study Group on

Dr. John Cush RheumNow

3 months 3 weeks ago
A Field Whose Time Has Come: Launching the EULAR Study Group on Geriatric Rheumatology EULAR launches a Study Group on Geriatric Rheumatology β€” clinics increasingly serve older patients with multimorbidity, polypharmacy, frailty, cognitive and functional limits, yet research
πŸŽ—οΈ Do targeted therapies raise cancer risk in SpA?
French nationwide cohort (n=56,591): NO

In fact, prolonged exp

Nelly ZIADE πŸ€ Nellziade

3 months 3 weeks ago
πŸŽ—οΈ Do targeted therapies raise cancer risk in SpA? French nationwide cohort (n=56,591): NO In fact, prolonged exposure REDUCES risk (wHR 0.86), especially haematological. #OP0238 #EULAR2026 @RheumNow https://t.co/dDveAmWpdX
πŸ’‰ Does ivarmacitinib (selective #JAK1i work in nr-axSpA?

Phase 3 RCT (n=304):
ASAS40 39.7% vs 24.8% placebo at wee

Nelly ZIADE πŸ€ Nellziade

3 months 3 weeks ago
πŸ’‰ Does ivarmacitinib (selective #JAK1i work in nr-axSpA? Phase 3 RCT (n=304): ASAS40 39.7% vs 24.8% placebo at week 12 with sustained benefit at week 24 #OP0237 #EULAR2026 @RheumNow https://t.co/kofXnPp6qQ
Window of opportunity in stills disease is early. With IL1 / IL6 agents
#sJIA and #AOSD are the same disease. - may need

Bella Mehta bella_mehta

3 months 3 weeks ago
Window of opportunity in stills disease is early. With IL1 / IL6 agents #sJIA and #AOSD are the same disease. - may need a standard new crieteria IL18 measuremnet should be encouraged. @RheumNow #EULAR2026 plenary https://t.co/EQbs9mDYjS
Who should we screen for RA-ILD?

RA-ILD remains a serious extra-articular manifestation, contributing to morbidity and

Mrinalini Dey DrMiniDey

3 months 3 weeks ago
Who should we screen for RA-ILD? RA-ILD remains a serious extra-articular manifestation, contributing to morbidity and mortality. At #EULAR2026, two abstracts shed light on clinical phenotyping and risk profiling. Read my report for @RheumNow: https://t.co/CTtYHINXxU
πŸ’Š After TNFi failure in axSpA, switch to IL-17Ai or cycle TNFi?

ROC-SpA (Phase 4 RCT, n=300):

NO difference: ASAS

Nelly ZIADE πŸ€ Nellziade

3 months 3 weeks ago
πŸ’Š After TNFi failure in axSpA, switch to IL-17Ai or cycle TNFi? ROC-SpA (Phase 4 RCT, n=300): NO difference: ASAS40 15.2% vs 14.5% at week 24 #OP0235 #EULAR2026 @RheumNow https://t.co/45gisWiuoM
πŸ”¬ Can filgotinib improve axSpA?

OLINGUITO (Phase 3 RCT, n=495):

YES! ASAS40 39.5% vs 21% (r-axSpA) at week 16

#O

Nelly ZIADE πŸ€ Nellziade

3 months 3 weeks ago
πŸ”¬ Can filgotinib improve axSpA? OLINGUITO (Phase 3 RCT, n=495): YES! ASAS40 39.5% vs 21% (r-axSpA) at week 16 #OP0234 #EULAR2026 @RheumNow https://t.co/0vj2KqSS1b
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