Here's the counterpoint to the previous positive tweet on vagal nerve stimulation in RA. The previously promising data on auricular vagus stimulation falls flat on further study Abstr#0837 #ACR23 @RheumNow https://t.co/APnrPhWA9q https://t.co/adA0H1VETt

This is particularly interesting considering this 👇🏼👇🏼 First RCT of NI auricular vagal nerve stimulation did not meaningfully improve RA disease activity or outcomes. No SAEs Is this supporting the need for other VNS modalities? @RheumNow #ACR23 ABST0837 https://t.co/yFcMPoSc31 https://t.co/G069XwUyAz

Late-Breaking Ph 2b RCT of TAK-279, oral TYK2 Inhib, in Active PsA. ACR20 in 53-54% (30 mg qd) vs 29.2% PBO at wk 12 (p = 0.002). Abst #L12 presented on Tuesday. #ACR23 

#ACR23 Abstr#0782 Triple therapy in #lupus nephritis. Propensity match data AURORA vs ALMS showed pts treated with voclosporin+MMF+low dose GC vs MMF+High dose GC achieved earlier reduction in UPCR & fewer AEs. Cdnt control for everything e.g. HCQ but assuring @RheumNow #ACRBest https://t.co/dmriAyQPr0

Clinical pearls in #CNS vasculitis: Dr. R.Hajj-Ali 🧠Clinical dx is difficult bec it presents w/ an array of clinical features 🧠CSF analysis essential in dx; can r/o infexns 🧠Nonvasc imaging highly sensitive 🧠biopsy is valuable esp when alt dx is considered #ACR23 @RheumNow https://t.co/QOAfSHn8ND

What is D2T PsA? A proposal of definition in ABST0777 Thoughts: A lot of features are extrapolated from the EULAR RA definition RA & PsA population are hardly comparable Lack of emphasis more problematic domains ie. dactylitis Further work is required @RheumNow #ACR23 https://t.co/A28e6XBME3

DRESS-PS study LTE. 12 month observational extension. 114 patients PsA/AxSpA. Essentially patients TNFi tapered or not in T2T fashion. TNFi dose remained lower in tapering group but it is consistently creeping back up. Abstr#0775 @RheumNow #ACR23 https://t.co/aYoOl6Ccin https://t.co/BtMR95lIfs

Fascinating how upadacitinib may well have an effect on pain in RA, beyond inflammation. Now seen similar for bari in RA & guselkumab in PsA. And, if real, for some people could be a massive get. Love to see dedicated studies SELECT-COMPARE post-hoc #ACR23 ABST0429 @RheumNow https://t.co/Tk278mGJYY

MEDIPSA: probiotic vs PBO RCT in PsA 12 weeks Using strains Bifidobacterium and Lactobacillus No effect on DA or PROMs in PsA No effect on gut parameters either Good safety profile Wrong strains or not an generally efficient intervention? ABST0778 @RheumNow #ACR23 https://t.co/RPgT7LoRgC

What do you think of CAR T Rx in severe #SLE? @RheumNow @ACRheum #ACR23

Ab#0596 #ACR23 @RheumNow R Furie on Decravacitinib in SLE 48wk double-blind trial. PBO v DEU 3mgBID, 6 mgBID,12 mg qd Higher response, faster time to SRI(4), BICLA and dual response v PBO. More likely to sustain response from w32-48. https://t.co/M34d3nQmwv