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Study of 3082 pts w/ muscle disease; 14 had adult IIM w/ myocarditis. Mean: 54 yrs, 71% black, Antisynthetase syndrome i

Dr. John Cush RheumNow

3 years ago
Study of 3082 pts w/ muscle disease; 14 had adult IIM w/ myocarditis. Mean: 54 yrs, 71% black, Antisynthetase syndrome in 64% (Jo1=4, PL12=3); 79%) w/ active myositis, 93% hosp); 5 yr myocarditis survival 53% (6 died; all w/ LVEF < 40%) https://t.co/HChGMU2nBv https://t.co/36weNDoV97
NHANES study of &gt;204 million persons finds 19.6% w/ hyperuricemia (HUC) &amp; 4.1% w/ gout. Gout/HUC pts had higher

Dr. John Cush RheumNow

3 years ago
NHANES study of >204 million persons finds 19.6% w/ hyperuricemia (HUC) & 4.1% w/ gout. Gout/HUC pts had higher tisk (HR 2.4) of heart failure (HF), expecially w/ age, DM, CV, & CAD risk factors, & w/ HF, 5-yr survival was 59.9% & 55.9% (1.4x ^ mortality) https://t.co/IrAUHcOV85 https://t.co/2AWhMES28g
Research from the COVID-19 Global Rheumatology Alliance included surveys and data gathering from rheumatology patients. During the pandemic era there was rapid adoption of telemedicine by rheumatologists; and a recent study of patient perspectives shows that most found telemedicine to be at least as effective as in-person clinic visits, especially in dealing with making medication changes and discussion of disease activity.
Both Lupus Nephritis and Cutaneous lupus erythematosus (CLE) show evidence of tissue infiltrating T cells expressing hi

Dr. John Cush RheumNow

3 years ago
Both Lupus Nephritis and Cutaneous lupus erythematosus (CLE) show evidence of tissue infiltrating T cells expressing hi amouts of hypoxia-inducible factor-1 (HIF-1); HIF-1 inhibition improves skin/systemic disease & decreases T cell cytotoxic activity https://t.co/Yv2K5UKjUV https://t.co/sbfLl7ZUqh
Chinese study of 5530 RA pts found 546 (9.9%) who developed diabetes. DM risk was significantly lower w/ bDMARD (HR 0.51

Dr. John Cush RheumNow

3 years ago
Chinese study of 5530 RA pts found 546 (9.9%) who developed diabetes. DM risk was significantly lower w/ bDMARD (HR 0.51), MTX (HR 0.50) and HCQ (HR 0.52). TNF inhibitors were also protective (HR 0.69). https://t.co/hdkyqFXbbu https://t.co/baQORpq1HP
Prolonged irAEs? 318 pts treated with anti–PD-1 therapy for melanoma, 64% had acute irAEs (14%) grade 3-5). Chronic (&

Dr. John Cush RheumNow

3 years ago
Prolonged irAEs? 318 pts treated with anti–PD-1 therapy for melanoma, 64% had acute irAEs (14%) grade 3-5). Chronic (>3 mos) irAEs, seen in 46% (half >=grade 2, 68% had Sxs). Most commonchronic irAEs= hypothyroid (70%), arthritis (33%), dermatitis (17%) https://t.co/5SNeLTTPSk https://t.co/d6L5lnSwJR
IMMpulse study - 1 yr OL, phase 4 trial of risankizumab (150 mg, wk 0, 4) vs apremilast (30 mg bid) in 352 pts w/ modera

Dr. John Cush RheumNow

3 years ago
IMMpulse study - 1 yr OL, phase 4 trial of risankizumab (150 mg, wk 0, 4) vs apremilast (30 mg bid) in 352 pts w/ moderate plaque psoriasis. RIZ had superior efficacy at wk 16 w/ PASI90 score of 55.9% vs 5.1% for APR. https://t.co/dSLJA9Tsmx https://t.co/AHPHdmOtM3
Assessment of Psoriatic Arthritis: A Global Perspective

Drs. Antoni Chan, Nelly Ziade and Ihsane Hmamouchi discuss POS

Dr. John Cush RheumNow

3 years ago
Assessment of Psoriatic Arthritis: A Global Perspective Drs. Antoni Chan, Nelly Ziade and Ihsane Hmamouchi discuss POS1542 presented at EULAR 2023 in Milan, Italy https://t.co/mSNhAma78C https://t.co/dhikAgIW7t
Most rheumatoid arthritis (RA) patients 65 and older who had 5 mg/day of prednisolone added to standard care were successfully weaned from the steroid without seeing substantial increases in disease activity, researchers said.
The American College of Rheumatology (ACR) said it has already joined with hundreds of organizations to submit 26 health policy comment letters to federal officials this year—surpassing the 24 letters the College submitted in 2022.
The Cleveland Clinic Journal has published a full-read review of postural orthostatic tachycardia syndrome (POTS), a condition often seen in clinic with symptoms like fibromyalgia, but is clinically diagnosed with finding sustained tachycardia upon standing without orthostatic hypotension.
Cross-sectional study 365 RA pts showed eating half a pizza &gt;1 time/wk (vs. ≤2 times/mo) was assoc w/ 70% less Dz a

Dr. John Cush RheumNow

3 years ago
Cross-sectional study 365 RA pts showed eating half a pizza >1 time/wk (vs. ≤2 times/mo) was assoc w/ 70% less Dz activity; esp w/ more severe RA (80%) (benefit likely due to mozzarella & olive oil). YES, this was an italian study... https://t.co/6xKMIFdEWf https://t.co/UfpJO1xNe4
Metanalysis of remote Pt monitoring w/ electronic Outcome Measures (ePROMs) in #RA (4,473 pts, 7 studies) showed lower d

Dr. John Cush RheumNow

3 years ago
Metanalysis of remote Pt monitoring w/ electronic Outcome Measures (ePROMs) in #RA (4,473 pts, 7 studies) showed lower disease activity & higher remission rates in ePROM group (OR 1.65) & fewer F2F visits were needed in ePROM grp https://t.co/Va2Psx6zSc https://t.co/rdzam3ROJv
Antenatal Corticosteroids and Serious Infection in Offspring

A claims data study shows that maternal use of antenatal

Dr. John Cush RheumNow

3 years ago
Antenatal Corticosteroids and Serious Infection in Offspring A claims data study shows that maternal use of antenatal corticosteroids may be associated with an increased risk of serious infection in the offspring's first 12 months. https://t.co/0qHgQkQvs9 https://t.co/hv1ACFQSZB
Italian JAKi study, 685 pts Rx w/ BARI (48%), TOFA (31%), UPA (14%), filgotinib (7%), had half (47%) Rx JAKi as 1st line

Dr. John Cush RheumNow

3 years ago
Italian JAKi study, 685 pts Rx w/ BARI (48%), TOFA (31%), UPA (14%), filgotinib (7%), had half (47%) Rx JAKi as 1st line, prior to a biologic. AE of special interest (1137 PYs FU) in 18%, including 1 CVA, 3 deaths/infx. High CV risk pts = Hi AESI(23%) https://t.co/0NN60tvokZ https://t.co/Dzc7OG9Mmv
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