Metanalysis 62 RCTs & 16 LTE RCTs looks at neoplasia risk in JAKi, TNFi, MTX, PBO. Total CA rate=1.15/100PYs in RCTs. No diff in all CA between JAKi vs PBO or JAKi vs MTX (IRR 0.77); but JAKi had more CA than TNFi (1.50; 1.16, 1.94) https://t.co/aiJHQ5oPqt https://t.co/8MjJv728sh

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RA Biologics Lower COVID-19 Deaths, but Not Recovery Time Do abatacept, cenicriviroc, or infliximab improve time to recovery for patients hospitalized with COVID-19 pneumonia compared with standard care? https://t.co/o56m9WumiC. https://t.co/GHe1RprDnk

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Baricitinib Effective in JIA Subsets A phase 3 trial assessed a selective Janus kinase 1/2-inhibitor, baricitinib, in patients with juvenile idiopathic arthritis (JIA), demonstrating it's efficacy and safety compared to placebo. https://t.co/0CMzVCgsG8 https://t.co/NGE1pxsmcb

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Commercial claims analysis of 21,044 pts w/ simultaneous B/L TKA vs 126,264 matched unilateral TKA. 90 day risk showed B/L TKA had signif more pulmonary embolism (aOR 2.13), CVA (2.21), acute anemia (2.06), transfusion (7.8), 90d readmission (1.35) https://t.co/ZW7fa3fbfC https://t.co/nVqRospVIV

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JAMA: Prophylaxis for Pneumocystis Pneumonia - indications and Rx - Immuncompromised and Immunodeficient - Pts on Hi Dose Steroids - ANCA–associated vasculitis https://t.co/2VhLxc4VNo https://t.co/cXuY4Manrk

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ICYMI: ChatGPT - A Boon or Threat to Scientific Publication? https://t.co/nt4m6n27A3 https://t.co/oo88u5X86Z

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GCA and the Risk of Cerebrovascular Ischemic Events Cerebrovascular ischemic events (CIE) can be one of the most severe complications of giant cell arteritis (GCA), but is seen in 4-5% of GCA patients according to a recent French University Hospital. https://t.co/MAjgWg71vK https://t.co/UhMtiWf7gh

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Upadacitinib Outcomes in High Risk RA Patients A safety analysis of six phase III SELECT trials showed that higher-risk RA patients had an increased risk of MACE, malignancy (excluding NMSC) and VTE regardless of being treated with either UPA or ADA. https://t.co/7JXntIV09K https://t.co/CthPcu2Ohs

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A double-blind, sham-controlled RCT of auricular vagus nerve stimulation (VNS) showed NO meaningful improvement in 101 RA completers. @week 12, ACR20 was 25% for VNS vs 27% for sham (NS). Also NS was change in DAS28-CRP (–0.95 vs –0.66)(p 0.06) https://t.co/NubTu8mGq4 https://t.co/OQSIpHgLyn

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ICYMI: Hydroxychloroquine Dose and Risk for Incident Retinopathy A cohort study in Annals of Internal Medicine shows that higher hydroxychloroquine doses was associated with progressively greater risk for incident retinopathy. https://t.co/SLgUKQKbFs https://t.co/xCc2D5Hx8S

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ICYMI: 25 Great Women in Rheumatology https://t.co/ghCAUBMMja https://t.co/cr2xI2VrgE

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