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Cytoplasmic Autoantibodies in the Anti-Synthetase Syndrome

Patients known to be autoantibody positive (e.g., anti- Jo1) for the anti-synthetase syndrome were assayed by indirect immunofluorescence (IIF) for other reactivities, showing antinuclear staining (ANA) or cytoplasmic staining (Anti-Cyt Ab+).

Intra-articular Corticosteroids or Methotrexate for Oligoarticular JIA?

Oligoarticular-onset juvenile idiopathic arthritis accounts for nearly half of all JIA patients. While many of these children will require DMARD therapy, many others are treated with antiinflammatory meds or intra-articular corticosteroids. But the evidence for this latter approach is scant.

Novel Peripheral Helper T Cells in RA

US and UK researchers have identified a unique subset of helper T-cells called ‘peripheral helper’ T-cells in the synoviums that may be linked to the pathogenesis of rheumatoid arthritis.

NSAIDs Ineffective in Back Pain

The George Institute for Global Health has performed a systematic review of drugs used to treat back pain. Their findings, published in the Annals of the Rheumatic Diseases, shows that only one in six improve their pain with NSAID therapy.

No Increase in Infections with Pre-Op Infliximab Before Hip or Knee Replacement

Up to 30% of patients with rheumatoid arthritis (RA) will eventually undergo joint reconstructive surgery, yet we have limited data to guide the perioperative management of DMARDs and biologics.

Modest Efficacy for Methotrexate in Psoriasis

Doubt remains regarding the appropriateness, efficacy and safety of methotrexate in the treatment of moderate to severe cutaneous psoriasis. Moreover, high dose, subcutaneous MTX has not been studied in a well-designed trial.

The RheumNow Week in Review – 3 February 2017

Dr. Jack Cush reviews this week's highlights from RheumNow.

Kevzara (Sarilumab) Approved in Canada for RA

Kevzara (sarilumab), an interleukin-6 (IL-6) receptor monoclonal antibody, was approved by Health Canada for use in rheumatoid arthritis (RA).

Gout is Undermanaged

Gout should be one of the easiest and best managed of rheumatic disorders.  However, numerous deficits exist with regard to the treatment and long-term care of gout.

Limited Efficacy of NSAIDs in Spondyloarthritis

Prior to the biologic era, nonsteroidal antiinflammatory drugs (NSAIDs) were the mainstay of drug therapy in thos with spondyloarthritis (SpA) and ankylosing spondylitis (AS).  Their role in the modern era has changed and the claims for efficacy have varied. 

Is the Jury Still Out on Triple Therapy vs. MTX + TNF inhibitor?

There are several trials that test the efficacy and safety of combination tumor necrosis factor inhibitor (TNFi) plus methotrexate against triple therapy (methotrexate plus hydroxychloroquine plus sulfasalazine) in patients with rheumatoid arthritis.

Increased Cardiovascular Risk with Gout

Most patients who present with gout to rheumatology clinics are at very high risk of cardiovascular (CV) disease, Spanish researchers found.

Curbside Consults - January 2017

Curbside Consults are cases submitted by our rheumatology colleagues as challenging therapeutic or safety issues. Answers are based on experience, with added evidence from the medical literature and published guidelines.

Efficacy of Pneumococcal Vaccine in RA Patients

Infection is a major cause of morbidity and mortality in RA patients and thus vaccinating against preventable infections is a top priority for rheumatologists.

The RheumNow Week in Review – 27 January 2017

Dr. Cush reviews highlights from the past week on RheumNow.com.

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