Today the U.S. Food and Drug Administration approved baricitinib (Oluminant) at the lower dose of 2 mg per day for use in adults with with moderate-to-severe active rheumatoid arthritis (RA) who have had an inadequate response to commonly-used treatments known as TNF inhibitors.
Dr. Jack Cush reviews this weeks reports from RheumNow.com, including the risk of autoimmunity with vaccination, early RA outcomes, new FDA approvals for certolizumab and tofacitinib and the risk of death from infection with biologics.
de Winter and colleagues from the Netherlands have reported on magnetic resonance imaging of the sacroiliac joints of healthy subjects, patients with axial spondyloarthritis, runners and those with chronic back pain, and found a high incidence of sacroiliitis in many, but that deep bone marrow edema was most specific for those with axial SpA.
Treatment of refractory giant cell arteritis (GCA) with ustekinumab (Stelara) showed therapeutic promise as a steroid-sparing agent in a small, open-label study, Irish researchers reported.
A meta-analysis has suggested that obesity is an under-reported predictor of inferior response to tumor necrosis factor blockade (anti-TNF) in a range of inflammatory immune-mediated inflammatory diseases (IMIDs), with the results showing a 60% risk of impaired response to anti-TNF across several
Canadian researchers have analyzed population data and shown that the incidence and prevalence of depression, anxiety and bipolar disorders are elevated in the rheumatoid arthritis (RA) patients compared to a matched population.
The American College of Physicians have published a position paper in Annals of Internal Medicine calling for an examination of the challenges facing women in the U.S.
Patients with psoriatic arthritis (PsA) were at increased risks for malignancy, and possibly more so if they were treated with conventional disease-modifying antirheumatic drugs (DMARDs), a meta-analysis found.
In nine cohort studies that included more than 43,000 PsA patients, the pooled relative risk for overall malignancy was 1.29 (95% CI 1.04-1.60) compared with the general population, according to Yunyun Fei, MD, and colleagues from Peking Union Medical College in Beijing.
Adults with osteoarthritis (OA) of the knee who frequently experienced restless sleep were less likely to engage in potentially beneficial moderate-to-vigorous physical activity, analysis of data from the Osteoarthritis Initiative found.
Dr. Jack Cush reviews this past week's news from RheumNow.com - the risk of Cutaneous and Systemic LE, increasing flu vaccination, higher risk of VTE, MPO predictions, new drug for GIOP and CIRT - MTX in cardiovascular risk patients.
The current issue of Annals of Internal Medicine examines patterns of potential opioid misuse that are associated with subsequent adverse outcomes nationally.
A study of MPO-ANCA positive patients followed serially over 2 years shows that reappearance of MPO‐ANCA may predict relapse in patients with MPO‐ANCA positive AAV and that routine MPO‐ANCA monitoring is warranted.
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