MTX is a prodrug! MTX polyglutamate is true active ingredient 1/2 of MTX PG is 60 days, compared to only 6-8 horus for MTX Steady state is not until 27.5 weeks! Joel Kremer at #RNL2023 @RheumNow https://t.co/hodFZ2oi11

Do you stop MTX on patients on bDMARD? MTX decrease anti-drug antibodies on patients on infliximab - increases drug duration. Similar seen with new combination usage with pelogloticase Joel Kremer MD #RhuemNow @RheumNow https://t.co/8UrGZaFStA

“We valued sports, wit, and friendship. By all accounts that would make him a rich man but that was before COVID19.” @RheumNow #RNL2023 introduces “Miracle Larry”who battled 128 days hospitalized from the pandemic (and 62 years of knowing Cush!) https://t.co/91p5nPl0n9

How do you wean MTX? Consider every other week dosing as options - supported by 2 randomized studies from 1995 and 1999 Option to lower weekly dosing in patients that want to take less often Joel Kremer #RNL2023 @RheumNow https://t.co/3GMdn3lLhy

MTX lung disease: Presents at 6-12 months Baseline CXR is key to know if lung infiltrates are new #RNL2023 @RheumNow https://t.co/Whu4O1GLA9

Do and don’t around MTX , Dr.Kremer approach to MTX #RNL2023 ⁦@RheumNow⁩ https://t.co/dXLQ0epsp4

@Janetbirdope at #RNL2023 RA is not a disease of young Incidence increasing in elderly population, not often offered the full range of medications due to co-morbidities, despite safety data Higher DAS, seroneg Co-morbidities decrease outcomes @RheumNow

Myths of RA by Dr. Janet Pope - RA development should have ACPA years before? - there is a significant minority of early RA patients who are seronegative! @RheumNow #RNL2023 https://t.co/pnOxTkfW0l

How much of RA risk is attributed to lifestyle? @Janetbirdope presents Nurse's Health Study showing 35% BMI and smoking increase risk of RA... in patients with ACPA positivity #RNL2023 @RheumNow https://t.co/g9DIrgc7pk

@Janetbirdope #RNL2023 Benefit of intra-articular jt injections in early RA Injection of 6-12 swollen joints (!) vs systemic glucocorticoids -- FAR better ACR20 and ACR50 with less side effects @RheumNow https://t.co/AtgCKOd8IC