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EHR study of UK Clinical Practice Research Datalink studied 318 hospitalized gout pts showing there is a 30d increased r

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Dr. John Cush
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EHR study of UK Clinical Practice Research Datalink studied 318 hospitalized gout pts showing there is a 30d increased risk of VTE after gout flare aIRR 2.31 (1.39-3.82), that disappeared 31-90d after. https://t.co/h2v8KbiSwX https://t.co/gsfnR50gTD

Danish Pop. study of frequency of TMJ and oro-facial Dz in 613 pts w/ #JIA followed 4 yrs. Cumulative incidence of TMJ

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Dr. John Cush
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Danish Pop. study of frequency of TMJ and oro-facial Dz in 613 pts w/ #JIA followed 4 yrs. Cumulative incidence of TMJ dz was 30%; 21% had arthritis-induced dentofacial deformity & dentofacial dysfunction (52%). TMJ predicted by younger onset, F, ANA+ https://t.co/M39q3snO3n https://t.co/ajPz27lmvt

Tigulixostat is a non-purine xanthine oxidase inhibitor studied in 143 gout pts vs PBO with goal of SUA < 5. TIG was

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Dr. John Cush
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Tigulixostat is a non-purine xanthine oxidase inhibitor studied in 143 gout pts vs PBO with goal of SUA < 5. TIG was effective at 50mg (47%), 100 mg (45% ), 200 mg (62%) vs PBO 2.6% at week 12; w/ more gout flares in PBO Rx pts (13% vs 9%) https://t.co/d9lAjCBUmZ https://t.co/BERW51HW2B

PR3 autoreactive CD4+T cells found in affected kidneys of 72 pts with PR3+ ANCA assoc vasculitis. These cytotoxic GPR56+

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Dr. John Cush
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PR3 autoreactive CD4+T cells found in affected kidneys of 72 pts with PR3+ ANCA assoc vasculitis. These cytotoxic GPR56+CD4+T cells were significantly greater in those with inactive (vs active GPA), suggesting they may be affected by immunosuppression https://t.co/dHFhgnB8yE https://t.co/ZxV6INeCrU
Specific ACPAs and Autoantibodies Lead to RA-Associated ILD

A BRASS registry study shows that specific isotypes of anti-citrullinated protein antibodies (ACPAs) can be associated with incident rheumatoid arthritis-associated ILD (RA-ILD). Early idtentification of RA-ILD is extremely important as it is a major contributor to premature death among patients with RA.

Gingival Inflammation Parallels Saliva “Cytokine Score” Researchers at NYU College of Dentistry have developed a s

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Dr. John Cush
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Gingival Inflammation Parallels Saliva “Cytokine Score” Researchers at NYU College of Dentistry have developed a single score to describe the level of cytokines in the saliva, and this score is linked with the severity of clinical gum inflammation. https://t.co/yIk4ddETeh https://t.co/6KNPe77LIV
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