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Pregnancy & Lupus

When is the risk of SLE flares greatest with pregnancy?

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Which of these medications is NOT ‘pregnancy compatible’ in SLE?

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A woman with positive lupus anticoagulant and a history of preeclampsia. What do you recommend for her NEXT pregnancy?

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What is the preferred contraceptive for lupus patients?

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What is the strongest risk factor for fetal congenital heart block (CHB)?

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T/F : detection of heart block is most common between 18 - 25 weeks of gestation.

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T/F: Risk of CHB is seen with both low and high titer anti-SSA/Ro antibodies.

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Who usually manages SLE or APS patients who become pregnant?

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T/F: All SLE and APS pregnancies are “high risk” pregnancies.

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I am a:...

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JAMA CME review of Immune Thrombotic Thrombocytopenic Purpura (iTTP) - thrombotic microangiopathy w/ hemolytic anemia (

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Dr. John Cush
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JAMA CME review of Immune Thrombotic Thrombocytopenic Purpura (iTTP) - thrombotic microangiopathy w/ hemolytic anemia (MAHA) & thrombocytopenia. iTTP incidence is 2-6 per million. Caused by Abs to ADAMTS13), w/ low ADAMTS13 activity vWF multimers bind platelets https://t.co/kwKXUciBd1

Annals of Internal Medicine has published a CME review of LYME DISEASE. Most Lyme is Dx by onset of the erythema migran

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Dr. John Cush
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Annals of Internal Medicine has published a CME review of LYME DISEASE. Most Lyme is Dx by onset of the erythema migrans rashes,. Lyme Ab testing is of low sensitivity at onset but more sensitive w/ time & CNS, CV complications. or Mono- or oligoarticular arthritis https://t.co/NfL0dabeGe
IMPACT Study - Certolizumab Efficacy in APS Pregnancies
A pilot trial assessed the safety and value of tumour necrosis factor α inhibitor treatment with certolizumab in patients with high-risk pregnancies with antiphospholipid syndrome (APS).

Hydroxychloroquine for Everyone Nearly 25 years ago, while lecturing on best therapies for rheumatoid arthritis (RA),

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Dr. John Cush
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Hydroxychloroquine for Everyone Nearly 25 years ago, while lecturing on best therapies for rheumatoid arthritis (RA), I loudly stated that hydroxychloroquine was “useless” and, deservedly, I was “boo-ed” off stage. My point then was that rheumatologists needed to be aggressive, https://t.co/qKnObzr5ib

Biologics in Pregnancy Patients With Autoimmune Disease A large cohort, claims data study shows that among pregnant wo

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Dr. John Cush
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Biologics in Pregnancy Patients With Autoimmune Disease A large cohort, claims data study shows that among pregnant women receiving biologic therapies for autoimmune conditions, 72% continued their biologics pregnancy, more so among inflammatory bowel disease (IBD) patients https://t.co/CH60gShlH0

SLE, Antiphospholipid Antibodies, and the Placenta It is well established that women with SLE are at increased risk fo

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Dr. John Cush
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SLE, Antiphospholipid Antibodies, and the Placenta It is well established that women with SLE are at increased risk for adverse pregnancy outcomes, including preeclampsia, preterm birth, and pregnancy loss. However, the pathophysiologic mechanisms driving these complications https://t.co/z0BOT3xsuQ
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